Incidence and mortality trends of head and neck cancer in Croatia in the period 1988–2008

Znaor, Tin; Vučemilo, Luka; Kuliš, Tomislav; Znaor, Ariana

doi:10.3109/00016489.2012.743031

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…The importance of tobacco and alcohol on laryngeal cancer mortality is also reflected by the similarity of trends to those for lung cancer and other tobacco‐and alcohol‐related neoplasms . Moreover, as reported in a few other studies, over the last few decades declines were also observed in laryngeal cancer incidence, influenced by changes in risk factors exposures only, in the absence of populations programs of screening for the disease. Thus, the steady decrease and the changes in tobacco use in subsequent generations of European men largely explains the fall in male laryngeal cancer mortality in several countries, particularly in middle‐age .…”

Section: Discussionsupporting

confidence: 57%

Laryngeal cancer mortality trends in European countries

Chatenoud

Garavello

Pagan

et al. 2015

Intl Journal of Cancer

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After a steady increase between the 1950s and the 1970s, laryngeal cancer mortality has been levelling off since the early 1980s in men from most western and southern European countries and since the early 1990s in central and eastern Europe. To update trends in laryngeal cancer mortality, we analyzed data provided by the World Health Organization over the last two decades for 34 European countries and the European Union (EU) as a whole. For major European countries, we also identified significant changes in trends between 1980 and 2012 using joinpoint regression analysis. Male mortality in the EU was approximately constant between 1980 and 1991 (annual percent change, APC=−0.5%) and declined by 3.3% per year in 1991–2012. EU age‐standardized (world population) rates were 4.7/100,000 in 1990–91 and 2.5/100,000 in 2010–2011. Rates declined in most European countries, particularly over the last two decades. In 2010–11, the highest male rates were in Hungary, the Republic of Moldova, and Romania (over 6/100,000), and the lowest ones in Finland, Norway, Sweden, and Switzerland (below 1/100,000). In EU women, mortality was stable around 0.29/100,000 between 1980 and 1994 and slightly decreased thereafter (APC=−1.3%; 0.23/100,000 in 2000–01). We also considered male incidence trends for nine European countries or cancer registration areas. In most of them, declines were observed over recent decades. Laryngeal cancer mortality thus showed favourable trends over the last few decades in most Europe, following favourable changes in tobacco and, mostly for Mediterranean countries, alcohol consumption.

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Section: Discussionsupporting

confidence: 57%

Laryngeal cancer mortality trends in European countries

Chatenoud

Garavello

Pagan

et al. 2015

Intl Journal of Cancer

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“…Kopf-Hals-Tumoren "wahrscheinlich HPV-assoziierter" Lokalisationen zeigten einen jährlichen Anstieg der Inzidenzraten sowohl bei Männern (JPV: + 3,3 %; KI[0,2; 6,6]) als auch bei Frauen 2006 2007 2008 2009 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2 000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 Abb. [21], Dänemark [22], Großbritannien [23], Kroatien [24], Schweden [25] und den Niederlanden [26]. Der Rückgang der Inzidenz von Larynx-und Hypopharynxkarzinomen in westlichen Ländern wird mit dem sinkenden Tabakkonsum in Verbindung gebracht, die Zunahme der Inzidenz von Oropharynxtumoren hingegen mit HPV-Infektionen [27].…”

Section: Plattenepithelkarzinome Und Hpv-assoziationunclassified

Veränderung von Inzidenz und Mortalität von Kopf-Hals-Malignomen in Rheinland-Pfalz, 2000–2009

et al. 2014

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“…Over the past few decades, however, there has been a rise in HPV+ OPSCC [5,12–14]. In Croatia the trend between 1988 and 2008 was showing decreasing overall incidence of HNSCC [15], with more recent data corroborating the trend [4]. The proportion of HPV associated OPSCC is now approximately 70% in the developing countries, which is a substantial increase from previous rates [5,16].…”

Section: Introductionmentioning

confidence: 99%

“…In Croatia, only clinical guidelines for the treatment of laryngeal cancer currently exist, which is only a subset of HNSCC, accounting for ~33% of HNSCC cases in the country, while there are no guidelines for the treatment of cancers arising at other head-and-neck sites [15]. As HPV involvement seems to drive the increase of OPSCC incidence in developed countries, establishing guidelines for this cancer type could be of a future benefit to patients, but the baseline data for such guidelines are scarce.…”

Section: Introductionmentioning

confidence: 99%

HPV-driven oropharyngeal squamous cell cancer in Croatia — Demography and survival

et al. 2019

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ObjectivesHead and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Main HNSCC risk factors are tobacco, alcohol, and high-risk human papillomavirus (HPV). HPV+ oropharyngeal squamous cell cancer (OPSCC) usually have different etiology, increasing incidence and often show an improved survival when compared to HPV-negative cases. The objective of the current study was to retrospectively examine the influence of HPV on the survival of OPSCC patients in a non-Western population setting.Materials and methodsWe determined the presence of HPV DNA and/or RNA in 99 formalin-fixed paraffin embedded (FFPE) tissue samples of OPSCC patients treated between 2002 and 2015. Patients were compared based on laboratory, demographic, clinical, life style characteristics and survival.ResultsHPV RNA was found in 29.3% cases. However, groups based on HPV data (either RNA, DNA or retrospectively collected p16 staining) did not show significant differences. Overall, 5-year survival was 30% with minimal influence of the HPV positivity.ConclusionsThe HPV influence on survival of OPSCC patients is not identical between populations probably due to other factors overshadowing the HPV effect. This should be taken into account when treatment or policy decisions are made in each particular setting.

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Incidence and mortality trends of head and neck cancer in Croatia in the period 1988–2008

Cited by 9 publications

References 11 publications

Laryngeal cancer mortality trends in European countries

Laryngeal cancer mortality trends in European countries

Veränderung von Inzidenz und Mortalität von Kopf-Hals-Malignomen in Rheinland-Pfalz, 2000–2009

HPV-driven oropharyngeal squamous cell cancer in Croatia — Demography and survival

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