Incidence, and natural history of inflammatory bowel disease in Castilla y León:Prospective and multicenter epidemiological study

Sáiz-Chumillas, Rosa María; Barrio, Jesús; Fernández-Salazar, Luis; Lara, Arias; Ausín, Mónica Sierra; Piñero, Concepción; Coronel, Ana Fuentes; Mata, Laura; Vásquez, Mónica; Carbajo, Ana; Alcaide, Noelia; Cano, Noelia; Nuñez, Aejandro; Paola, Fradejas; Ibáñez, Mercedes; Hernández, Luis; Sicilia, B

doi:10.1016/j.gastre.2022.04.009

Cited by 2 publications

(2 citation statements)

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“…CD patients cost a lot of medical care, and nearly 35% of them were hospitalized. Systemic steroids, immunomodulatory therapy, biological therapy and surgery are the mainly therapy for CD patients (Chaparro et al 2021;Sáiz-Chumillas et al 2022).…”

Section: Introductionmentioning

confidence: 99%

A diagnostic model based on gene biomarkers for Crohn’s disease

Wu¹,

Lin²,

Wang³

2023

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Crohn's disease (CD) is a segmental chronic inflammatory bowel disease, which seriously affects the patient's quality of life. The etiology of CD is not yet clear, and there is still a lack of effective treatments. Therefore, in this study, we focus on developing a useful model for early diagnosis and targeted therapy of CD. The expression datasets of CD were collected to filter differentially expressed genes (DEGs) by overlapping "limma" package and "WGCNA" package. Then, functional enrichment analysis and protein-protein interaction (PPI) network analyses were performed. Hub genes were screened with "cytoHubba" plug-in and filtered with LASSO and stepwise regression analyses. The logistic regression model and nomogram were established based on the selected hub genes. The 45 DEGs were identified and the top 30 hub genes were chosen out for further study. Finally, 11 genes were selected to construct the logistic regression model and nomogram. The receiver operating characteristic (ROC) curve shows that the area under the curve (AUC) value was 0.960 in the training dataset and 0.760 in the validation dataset. A 11-gene diagnostic model was constructed with IL1B, CXCL10, CXCL2, LCN2, MMP12, CXCL9, NOS2, GBP5, FPR1, GBP4 and WARS, which may become potential biomarkers for early diagnosis and targeted therapy of CD.

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Section: Introductionmentioning

confidence: 99%

A diagnostic model based on gene biomarkers for Crohn’s disease

Wu¹,

Lin²,

Wang³

2023

gpb

View full text Add to dashboard Cite

show abstract

“…Despite the increasing number of patients receiving biotherapies, surgery is still an essential tool in the management of patients with CD [ 4 ]. The incidence of Crohn's disease was found to be much higher in the developed countries of western world than in Asia [ 5 ]. However, the incidence and prevalence of CD have been increasing in countries with traditionally low incidence of CD, especially in Asian countries including China [ 6 ].…”

Section: Introductionmentioning

confidence: 99%