Incidence and occupational variation of ovarian granulosa cell tumours in Finland, Iceland, Norway and Sweden during 1953–2012: a longitudinal cohort study

Abstract

Objective To determine the incidence and occupational variation of granulosa cell tumours (GCTs) in Finland, Iceland, Norway and Sweden over a 60-year period, 1953-2012. Design A longitudinal cohort study.Setting and population Finland, Iceland, Norway and Sweden and a total of 249 million women over a 60-year period . The NOCCA (Nordic Occupational Cancer Study) included 6.4 million women with 776 incident GCT cases diagnosed until the end of follow up.Methods Incidence rates were calculated from the national cancer registries and compared using quasi-Poisson regression models. Occupation-specific standardised incidence ratios (SIRs) were calculated from the Nordic Occupational Cancer (NOCCA) database.Main outcome measures Incidence rates and standardised incidence ratios.Results The age-adjusted (World Standard) incidence rates remained quite constant: about 0.6-0.8 per 100 000 for most of the study period. The age-specific incidence was highest at 50-64 years of age. There were no occupations with significantly increased risk of GCT. Major changes in the use of oral contraceptives, postmenopausal hormonal therapy, fertility rate and lifestyle in general during the study period and among different occupational categories do not appear to have a marked effect on the incidence of GCT.Conclusion Our findings support the concept of GCT as a primarily sporadic, not exposure-related, cancer.Keywords Epidemiology, granulosa cell tumour, incidence, Nordic, occupational.Tweetable abstract The Nordic incidence rates of GCTs show stability over time and among different occupational categories.

Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary

“…According to the 2014 World Health Organization histological classification of ovarian tumors, ovarian granulosa cell tumors are divided into two types: ovarian adult granulosa cell tumor (AGCOT) and ovarian juvenile granulosa cell tumor (JGCOT) [2]. Ovarian adult granulosa cell tumor, accounting for 95% of ovarian granulosa cell tumor, mainly occurs in perimenopausal and postmenopausal women and exhibits unpredictably late recurrence features [3][4][5][6]. Among the multiple prognostic factors reported, menopause, tumor diameter, estrogen and CA125 levels, International Federation of Gynecology and Obstetrics (FIGO) staging, residual lesions, multisite recurrence, and presence of mitotic figures have been mentioned as factors associated with the prognosis [7][8][9][10].…”

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary

“…Granulosa cell tumors (GCTs) of the ovary are very rare, and account for less than 5% of all ovarian malignancies [1,2]. Bryk et al found that the incidence of granulosa cell tumors was very low -0.6 to 0.8 per 100000 for their study period [3]. These tumors can be further divided into two distinct subtypes (juvenile GCTs and adult GCTs (aGCTs)) on the basis of their histologic, biochemical and molecular features.…”

The molecular mechanism of ovarian granulosa cell tumors

“…From the cancer databases in Finland, Iceland, Norway and Sweden, the GCT onset showed scattered feature. There was no increasing trend over the 60 years [ 5 ]. Abnormal cell cycle is related to the occurrence and development of cancers.…”