Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study

Ng, Siew C.; Tang, Whitney; Ching, Jessica; Wong, Man Leung; Chow, Chung Mo; Hui, Aric Josun; Wong, Tai Chiu; Leung, Vyl; Tsang, Steve; Yu, Hon Ho; Li, Mo; Ng, Ka Kei; Kamm, Michael A.; Studd, Corrie; Bell, Sally; Leong, Rupert W.; Silva, H. Janaka de; Kasturiratne, A.; Mufeena, M.N.F.; Ling, Khoon Lin; Ooi, Choon Jin; Tan, Poh Seng; Ong, David; Goh, Khean Lee; Hilmi, Ida; Pisespongsa, Pises; Manatsathit, Sathaporn; Rerknimitr, Rungsun; Aniwan, Satimai; Wang, Yu Fang; Ouyang, Qi; Zeng, Zhirong; Zhu, Zhenhua; Chen, Min Hu; Hu, Pin Jin; Wu, Kaichun; Wang, Xin; Simadibrata, Marcellus; Abdullah, Murdani; Wu, Justin C.Y.; Sung, Joseph J.Y.; Chan, Francis K.L.

doi:10.1053/j.gastro.2013.04.007

Cited by 684 publications

(637 citation statements)

References 29 publications

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“…In the Olmsted County cohort study , 81.4 % of patients had non-stricturing, non-penetrating disease at diagnosis; 64 % had ileal involvement at diagnosis [55]. The phenotype at diagnosis in patients with UC is generally split equally among proctitis, left-sided disease and pancolitis [56,57]. The proportion of patients presenting with pancolitis increased over the five decades in Denmark [45].…”

Section: The Changing Phenotype Of Ibdmentioning

confidence: 99%

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The microbiota in inflammatory bowel disease

2015

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This review explores our current understanding of the complex interaction between environmental risk factors, genetic traits and the development of inflammatory bowel disease. The primacy of environmental risk factors is illustrated by the rapid increase in the incidence of the disease worldwide. We discuss how the gut microbiota is the proximate environmental risk factor for subsequent development of inflammatory bowel disease. The evolving fields of virome and mycobiome studies will further our understanding of the full potential of the gut microbiota in disease pathogenesis. Manipulating the gut microbiota is a promising therapeutic avenue.

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Section: The Changing Phenotype Of Ibdmentioning

confidence: 99%

“…Male predominance [57] of increased ileocolonic disease has been described amongst Asian cohorts of patients with CD. However, a recent study failed to show a significant difference in disease location between Asian and Australian cohorts [57].…”

Section: The Changing Phenotype Of Ibdmentioning

confidence: 99%

The microbiota in inflammatory bowel disease

2015

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“…The homogenates were centrifuged at 3000 g for 15 minutes at 4°C for cytosolic separation. Serum was separated from whole blood and was used to quantify the lipid profile such as total cholesterol (TC) [7], phospholipids (PL) [8], triglycerides (TG) [9], free fatty acids [10], and high-density lipoprotein (HDL) [11]. Low-density lipoprotein (LDL) was calculated using the following formula:…”

Section: Biochemical Analysismentioning

confidence: 99%

Alterations of Lipid profile levels in 7,12-Dimethylbenz(a)anthracene induced ulcerative colitis rat model.

Palaniswamy¹,

B²,

Indra³

et al. 2017

Asian J Pharm Clin Res

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Objective: Ulcerative colitis is a type of inflammatory bowel disease is a chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. We examined the lipid profile levels in murine model of 7,12-dimethylbenz(a)anthracene induced ulcerative colitis.Methods: Serum was separated from whole blood and was used to determine the lipid profile such as total cholesterol (TC), phospholipids (PL), triglycerides (TG), free fatty acids, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C). Results:Ulcerative colitis rats exhibit a low level of LDL-C and TC. No significant difference was observed in HDL and TG, and significant difference was observed in PL and free fatty acid serum levels. This communication highlights the lipid profile that occurs in ulcerative colitis. Conclusion:This study, thus, provides valuable information about the disturbances in the lipids and lipoproteins occur in ulcerative colitis.

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“…Crohn's disease (CD) is a chronic and relapsing intestinal inflammatory disease which influences millions of people in Europe, with an increasing prevalence in Asia and other developing countries [1,2]. It is generally accepted that CD is a genetically predisposed, environmentally triggered complex disease [3].…”

Section: Introductionmentioning

confidence: 99%

A Novel Strategy to Identify mRNA 3′ UTR and mRNA Level Difference in Crohn’s Disease

Hu¹,

Liu²,

Zhou³

et al. 2017

Chemotherapy (Los Angel)

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Background and Aims: Crohn's disease (CD) is a chronic and refractory intestinal inflammatory disease. The 3′ untranslated region (3′ UTR) of mRNA transcript can regulate its own translational process post-transciptionally, and its role in CD remains unclear. The aim of this study was to identify the critical genes influencing CD phenotype via the regulation of mRNA 3′ UTR. Methods:Isoform Structural Change Model (IsoSCM) was used to evaluate the length of 3′ UTR of the whole transciptome from a RNA-seq based online CD database. Correlations between 3′ UTR length status and mRNA level were analyzed by Spearman coefficients. Correlated genes list was overlapped with published critical CD related gene list. Univariate and multivariate analysis were performed to identify the genes associated with CD phenotype. Results:Compared with normal control, 3′ UTR of 34192 genes were shortened and 57389 were lengthened among 432784 genes in CD patients. The 3′ UTR changes of 255 genes were found significantly correlated with their mRNA level. Furthermore, 8 overlapped genes were shared by above 255 correlated genes and known CD related gene list (ABCB1, FAF1, TUT2, IL27, JAK2, LTB, NAGLU and PTPN2). The mRNA level of ABCB1 and JAK2, and shortened 3′ UTR length of JAK2 transcript were found to be correlated with deep ulcer in CD patients by univariate and multivariate analysis. Conclusions:The 3′ UTR changes of CD related genes were confirmed to be related to the phenotype of CD. Our findings may provide further insight into the epigenetic mechanisms and therapeutic strategies for CD.

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Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study

Cited by 684 publications

References 29 publications

The microbiota in inflammatory bowel disease

The microbiota in inflammatory bowel disease

Alterations of Lipid profile levels in 7,12-Dimethylbenz(a)anthracene induced ulcerative colitis rat model.

A Novel Strategy to Identify mRNA 3′ UTR and mRNA Level Difference in Crohn’s Disease

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