Incidence and predictors of abdominal pain after transarterial chemoembolization of hepatocellular carcinoma: a single-center retrospective study

Du, Qianqian; Liang, Min; Jiang, Bo; Zhang, Miao; Yu, Xiaoling; Xiao, Li; Hao, Jinling

doi:10.1016/j.ejon.2023.102355

Cited by 2 publications

(1 citation statement)

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“…We identified that factors such as tumor number, size, microsphere volume, and operative time are closely associated with the occurrence of post-TACE pain ( 17 - 19 ). These findings are in line with previous studies, underscoring the relationship between tumor characteristics and post-treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a predictive scoring system for post-transarterial chemoembolization pain management in liver cancer patients

You,

Wang,

et al. 2024

J Gastrointest Oncol

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Background Patients experiencing severe postoperative pain often show lower adherence to prescribed treatments, highlighting the clinical need for effective pain prediction and management strategies. This study aims to address this gap by identifying key risk factors associated with post-transarterial chemoembolization (TACE) pain and developing a predictive scoring system. Methods We retrospectively analyzed data from liver cancer patients who underwent their first TACE procedure at our institution between January 2019 and December 2020. Pain levels were assessed using an 11-point numerical rating scale (NRS-11). Patients were randomly assigned to training and validation cohorts. In the training cohort, logistic regression was used to evaluate the correlation between various parameters and post-TACE pain, leading to the development of a risk prediction model. This model’s performance was subsequently assessed in the validation cohort. Results The study included 255 patients. Univariate analysis in the training cohort identified tumor number, size, microsphere volume, and operation time as factors associated with postoperative pain. These factors were included in a multivariate model, which demonstrated areas under the receiver operating characteristic (ROC) curve (AUCs) of 0.71 in the training cohort and 0.74 in the validation cohort for predicting moderate to severe pain. A nomogram was also developed for clinical application, categorizing patients with scores above 72.90 as high risk for moderate to severe pain. Conclusions Our research successfully developed and validated a novel scoring system capable of predicting moderate to severe pain following initial TACE treatment. However, the study’s predictive accuracy, as reflected by AUC values, suggests that further refinement and validation in larger, diverse cohorts are necessary to enhance its clinical utility. This work underscores the importance of predictive tools in improving postoperative pain management and patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Development and validation of a predictive scoring system for post-transarterial chemoembolization pain management in liver cancer patients

You,

Wang,

et al. 2024

J Gastrointest Oncol

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A risk prediction model for nausea and vomiting after TACE : a cross-sectional study

Dai,

Zeng,

et al. 2024

Preprint

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Purpose It was found that 52.5% of patients experienced nausea and vomiting after Transcatheter Arterial Chemoembolization (TACE), but there are no models that predict this risk. In this study, we investigated the factors associated with nausea and vomiting after TACE and developed a predictive model to predict these adverse events. Method The study will include 401 patients who will be randomly assigned to the training group and validation group in a 7:3 ratio. An analysis of logistic regression was used to identify predictors and build a risk prediction model. Model performance was evaluated using the Area Under Curve (AUC), Calibration Curve, and Decision Curve Analysis (DCA). Results This study ultimately included 401 patients for TACE, of whom 132(32.92%) patients experienced nausea and vomiting. There were independent risk prediction models for the history of vomiting, the preventive use of antiemetic, pain, and platinum and anthracene. Testing and training groups had AUCs of 0.839 and 0.742, respectively. They had calibration curves with P = 0.208 and P = 0.482, respectively. The DCA curves showed that the model had good clinical benefit at threshold probabilities greater than 20%. Conclusion The prediction model has good discriminatory ability, accuracy evaluation and clinical efficacy and is presented by nomogram with strong operability, contributing to for clinical medical staff to improve the management of TACE.

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Incidence and predictors of abdominal pain after transarterial chemoembolization of hepatocellular carcinoma: a single-center retrospective study

Cited by 2 publications

References 50 publications

Development and validation of a predictive scoring system for post-transarterial chemoembolization pain management in liver cancer patients

Development and validation of a predictive scoring system for post-transarterial chemoembolization pain management in liver cancer patients

A risk prediction model for nausea and vomiting after TACE : a cross-sectional study

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