Incidence and predictors of suicide attempts in bipolar I and II disorders: A 5‐year follow‐up study

Abstract

Funding information theFinnishMedicalFoundationObjectives: Fewlong-termstudiesonbipolardisorder(BD)haveinvestigatedtheincidenceandriskfactorsofsuicideattempts(SAs)specificallyrelatedtoillnessphases.WeexaminedtheincidenceofSAsduringdifferentphasesofBDinalong-termprospectivecohortofbipolarI(BD-I)andbipolarII(BD-II)patients,andriskfactorsspecificallyforSAsduringmajordepressiveepisodes(MDEs). MDEs, severity of depression, and cluster C personality disorders were significant predictors. Methods

Predominant polarity in bipolar I and II disorders: a five-year follow-up study

“…The impact of the mixed states on suicidality is of interest; Baldessarini et al (Baldessarini and Undurraga et al2012) found that when mixed states were combined with the depressive category, the association of the DP group with suicide attempts almost doubled. This is in accordance with the vast differences discovered in the incidences of suicide attempts during different illness states, with mixed phases having the highest risk (Pallaskorpi et al, 2017). We classified the mixed states (see Definition 2, Table 1) in accordance with the DSM-5 (American Psychiatric Association, 2013), which influences comparisons of some outcome measures with previous studies.…”

Impact of irritability: a 2‐year observational study of outpatients with bipolar I or schizoaffective disorder

“…Any potential association between irritability and suicidality is worth examining, given that a third to a half of bipolar disorder patients attempt suicide at least once and that 15–20% die by suicide . When examining factors that contributed to suicide in people with schizophrenia, schizophreniform, or schizoaffective disorder, meeting the criteria for a concurrent DSM IV diagnosis of mood disorder significantly increased the risk of suicide .…”

“…Despite treatment advances, many people with bipolar and schizoaffective disorder are still burdened by disruptive symptoms, impaired functioning, QoL, social support, and increased suicidality. Recognizing irritability and its potential impact might help to tailor effective pharmacological and psychosocial treatments to people with mood episodes …”

Modeling suicide in bipolar disorders

“…Proximal and distal risk factors that increase the likelihood of suicidal behaviors in bipolar disorder from multiple sources [Colour figure can be viewed at wileyonlinelibrary.com]…”