Incidence and predisposing factors of extra-articular manifestations in contemporary rheumatoid arthritis

Ljung, Lotta; Jönsson, Elias; Franklin, Johan; Berglin, Ewa; Lundquist, Anders; Rantapää-Dahlqvist, Solbritt

doi:10.1016/j.ejim.2024.04.026

European Journal of Internal Medicine

2024

DOI: 10.1016/j.ejim.2024.04.026

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Incidence and predisposing factors of extra-articular manifestations in contemporary rheumatoid arthritis

Lotta Ljung,

Elias Jönsson,

Johan Franklin

et al.

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Cited by 3 publications

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Extra-articular manifestations in rheumatoid arthritis: Incidence and predisposing factors

Wang,

Wu,

2024

European Journal of Internal Medicine

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Extra-articular manifestations in rheumatoid arthritis: Incidence and predisposing factors

Wang,

Wu,

2024

European Journal of Internal Medicine

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Effect of Aerobic Exercises on Ventilatory Functions in Women With Rheumatoid Arthritis: A Randomized Controlled Trial

Elgayar

2024

Women in Sport and Physical Activity Journal

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The goal of this research was to investigate the effects of aerobic exercises (AEs) on ventilatory functions, chest expansion, exercise capacity, and quality of life in women with rheumatoid arthritis. A total of 66 women diagnosed with rheumatoid arthritis were assigned randomly to two groups of the same size. Over a period of 12 weeks, the AE group engaged in aerobic workouts of moderate-to-high intensity, three times per week, along with diaphragmatic breathing exercises, whereas the control group only received diaphragmatic breathing exercises. Outcome measures included forced vital capacity, forced expiratory volume in the first second, total lung capacity, upper and lower chest expansions, maximal oxygen consumption, physical component score, and mental component score components of the 12-item Short Form Health Survey. Compared with baseline measurements, the AE and control groups exhibited substantial improvements in all outcomes by the completion of the trial (p < .05). Compared with the controls, the AE group revealed substantial increases in forced vital capacity (10.2% vs. 4.8%, p = .02), forced expiratory volume in the first second (8.9% vs. 4.07%, p = .01), total lung capacity (10.86% vs. 5.35%, p = .008), upper chest expansion (21.37% vs. 11.71%, p = .04), lower chest expansion (28.33% vs. 10.63%, p = .03), maximal oxygen consumption (30.7% vs. 15.01%, p = .01), physical component score (17.68% vs. 11.04%, p = .003), and mental component score (25.65% vs. 13.21%, p = .01). In women with rheumatoid arthritis, the addition of moderate-to-high AE to diaphragmatic breathing exercises could improve ventilatory functions, chest expansion, exercise capacity, and quality of life.

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The Association of Anti-CCP Positivity with Extra-Articular Manifestations in Patients with Rheumatoid Arthritis

Ullah,

Waris,

Zeb

et al. 2024

PBMJ

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Rheumatoid Arthritis (RA) is an autoimmune inflammatory disorder that primarily affects the joints. Objective: To examine association between anti-cyclic citrullinated peptide and extra-articular manifestation of Rheumatoid arthritis. Methods: It was a descriptive cross-sectional study in the Department of Rheumatology outpatient Khyber Teaching Hospital in Peshawar from 13th April 2023 to 13th September 2023. A descriptive cross-sectional study was conducted on 100 patients diagnosed with rheumatoid arthritis according to ACR/EULAR 2010 criteria at the Rheumatology outpatient department of Khyber teaching hospital in Peshawar from 13th April 2023 to 13th September 2023. Sampling technique was non probability consecutive. Statistical analysis was performed using SPSS version 23.0. Results: Our study involved 100 patients diagnosed with rheumatoid arthritis. Majority of the patients were female (90%) with overall mean age was 42.3 ± 10.06 years. The average duration of the disease was 5.9 years, with a mean RA disease activity score of 2.8. Extra-articular manifestations were observed in 84% of the patients, encompassing various symptoms such as anemia, subcutaneous nodules, episcleritis, and interstitial lung disease. Most patients (94%) tested positive for Rheumatoid Arthritis Factor, while 84% tested positive for anti-CCP antibodies. Our analysis revealed significant associations between the presence of extra-articular manifestations and factors such gender distribution, disease activity score and anti-CCP antibody positivity while no significance was noted for factors such as age, Rheumatoid Arthritis Factor and duration of disease. Conclusions: Our study concludes that anti-CCP was positively associated with the presence of extra-articular manifestation of Rheumatoid Arthritis.

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Incidence and predisposing factors of extra-articular manifestations in contemporary rheumatoid arthritis

Cited by 3 publications

References 31 publications

Extra-articular manifestations in rheumatoid arthritis: Incidence and predisposing factors

Extra-articular manifestations in rheumatoid arthritis: Incidence and predisposing factors

Effect of Aerobic Exercises on Ventilatory Functions in Women With Rheumatoid Arthritis: A Randomized Controlled Trial

The Association of Anti-CCP Positivity with Extra-Articular Manifestations in Patients with Rheumatoid Arthritis

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