Incidence and presentation of reported coeliac disease in Cardiff and the Vale of Glamorgan

Hurley, Joanna J.; Lee, Bee; Turner, Jeff; Beale, Amanda; Jenkins, Huw; Swift, G. L.

doi:10.1097/meg.0b013e328350f888

Cited by 18 publications

(18 citation statements)

References 15 publications

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“…Generally, our results are in accordance with reports from other Western countries reporting doubling rates in the United States, tripling rates in certain age groups in Scandinavia and quadrupling rates in the United Kingdom [21][22][23]. The explanation of the rising incidence is probably caused by a combination of factors.…”

Section: Discussionsupporting

confidence: 95%

Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010

Burger

Roovers

Drenth

et al. 2014

Scandinavian Journal of Gastroenterology

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Section: Discussionsupporting

confidence: 95%

Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010

Burger

Roovers

Drenth

et al. 2014

Scandinavian Journal of Gastroenterology

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“…4 A recent audit of children (,16 years; n = 69) diagnosed in Wales revealed a rising trend in pediatric CD incidence from a mean of 2.08/100 000 per year from 1981 to 1985 to 6.89/100 000 per year from 2001 to 2005. 5 Similar trends have been observed in Europe and North America over comparable time periods. [6][7][8][9][10] A number of articles also report that a greater proportion of children in more recent years are diagnosed through targeted screening and experience fewer GI symptoms.…”

Section: (Continued On Last Page)supporting

confidence: 68%

The Rising Incidence of Celiac Disease in Scotland

et al. 2013

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BACKGROUND AND OBJECTIVES: Although the incidence of pediatric celiac disease (CD) is increasing globally, it is uncertain whether this is attributed to improved case ascertainment or signifies a true rise. We aimed to identify all incident cases of childhood CD in southeast Scotland over the period 1990 to 2009 to assess trends in total incidence and cases diagnosed as a result of (1) a classic presentation, (2) a nonclassic presentation, or (3) targeted screening. METHODS: Twenty-year retrospective cohort study of case notes, pathology databases, endoscopy, and patient records for all children (<16 years of age) diagnosed with CD on biopsy in southeast Scotland (at-risk population of 225 000–233 000). Data were age-gender standardized and Poisson regression models used to calculate changes in incidence over time. RESULTS: A total of 266 children were diagnosed from 1990 to 2009 with an increase in incidence from 1.8/100 000 (95% confidence interval [CI] 1.1–2.7) to 11.7/100 000 (95% CI 9.8–13.9) between the epochs 1990 to 1994 and 2005 to 2009, respectively (P < .0001). The incidence of nonclassic presentation (children with a monosymptomatic presentation and those with extraintestinal symptoms) and actively screened cases increased by 1566% (P < .05) and 1170% (P < .001) from 1990 to 1999 to 2000 to 2009, respectively. However, a rise in the incidence of Oslo classic cases from 1.51/100 000 (95% CI 0.91–2.38) in 1990 to 1994 to 5.22/100 000 (95% CI 3.98–6.75) in 2005 to 2009 (P < .01) remained evident. CONCLUSIONS: The incidence of pediatric CD increased 6.4-fold over the 20 years. This study demonstrates that this rise is significant for classic CD, indicating a true rise in the incidence of pediatric CD.

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“…In contrast, there was a marked fall in the incidence of paediatric CD from the 1970s to the 1990s in England, Scotland and Ireland, although not Wales, attributed to changing infant feeding practices. On the other hand, four British studies, two of them consecutive in the same population, showed an increase in the incidence of adult CD from the 1960s to the 2000s . However, there was no change in Denmark from 1976 to 1991 .…”

Section: Resultsmentioning

confidence: 96%

“…Significant inter‐country differences are apparent. Considering various time periods together, incidence rates for both sexes combined ranged from 0.9 to 12.9/100 000/year for all ages combined, 0–3.7/1000 live births for children and 1.27–39/100 000/year for adults . Again considering various time periods together, prevalence rates for both sexes ranged from 8.1 to 204/100 000 for all ages, 4.7–250/100 000 for children and 45.9–550/100 000 for adults …”

Section: Resultsmentioning

confidence: 98%

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

231

182

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Summary Background Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub‐Saharan Africa. Aim To assess geographical differences and time trends in the frequency of CD. Methods Medline and Embase searches were conducted on 10 November 2012, from 1946 and 1980 respectively, using the key words: coeliac disease or celiac disease + prevalence or incidence or frequency. Results There were significant intra‐ and inter‐country differences in the prevalence and incidence of CD. Only 24 ethnic Chinese and Japanese patients have been reported in the English literature. Of CD‐associated HLA DQ antigens, DQ2 occurs in 5–10% of Chinese and sub‐Saharan Africans, compared to 5–20% in Western Europe. DQ8 occurs in 5–10% of English, Tunisians and Iranians, but in <5% of Eastern Europeans, Americans and Asians. The prevalence and incidence of both clinically and serologically diagnosed CD increased in recent years. These geographical and temporal differences seem genuine, although variable indices of suspicion and availability of diagnostic facilities are confounding factors. Conclusions Coeliac disease is increasing in frequency, with significant geographical differences. Although few cases have been described to date in the Orient and Sub‐Saharan Africa, there is a significant prevalence of HLA DQ2 and wheat consumption is of the same order as that in Western Europe. CD may therefore become more common in the future in these countries.

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Incidence and presentation of reported coeliac disease in Cardiff and the Vale of Glamorgan

Cited by 18 publications

References 15 publications

Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010

Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010

The Rising Incidence of Celiac Disease in Scotland

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

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