Incidence and Prevalence Analysis of Non-Small-Cell and Small-Cell Lung Cancer Using Administrative Data

Ricotti, Andrea; Sciannameo, Veronica; Balzi, William; Roncadori, Andrea; Canavese, P; Avitabile, Arianna; Nanni, Oriana; Berchialla, Paola

doi:10.3390/ijerph18179076

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…Adenocarcinoma is the most frequent LC type in women and non-smokers, accounting for 40% of LC ( Travis et al, 2011 ; Ricotti et al, 2021 ). Unlike squamous cell carcinoma, adenocarcinomas are usually smaller and peripherical in location.…”

Section: Histopathologymentioning

confidence: 99%

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Ion channels in lung cancer: biological and clinical relevance

Capitani,

Chioccioli Altadonna,

Santillo

et al. 2023

Front. Pharmacol.

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Despite improvements in treatment, lung cancer is still a major health problem worldwide. Among lung cancer subtypes, the most frequent is represented by adenocarcinoma (belonging to the Non-Small Cell Lung Cancer class) although the most challenging and harder to treat is represented by Small Cell Lung Cancer, that occurs at lower frequency but has the worst prognosis. For these reasons, the standard of care for these patients is represented by a combination of surgery, radiation therapy and chemotherapy. In this view, searching for novel biomarkers that might help both in diagnosis and therapy is mandatory. In the last 30 years it was demonstrated that different families of ion channels are overexpressed in both lung cancer cell lines and primary tumours. The altered ion channel profile may be advantageous for diagnostic and therapeutic purposes since most of them are localised on the plasma membrane thus their detection is quite easy, as well as their block with specific drugs and antibodies. This review focuses on ion channels (Potassium, Sodium, Calcium, Chloride, Anion and Nicotinic Acetylcholine receptors) in lung cancer (both Non-Small Cell Lung Cancer and Small Cell Lung Cancer) and recapitulate the up-to-date knowledge about their role and clinical relevance for a potential use in the clinical setting, for lung cancer diagnosis and therapy.

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Section: Histopathologymentioning

confidence: 99%

“…Squamous cell carcinomas account for 21% of LC ( AIOM, 2019 ; Ricotti et al, 2021 ), are more frequent in men and are highly related to smoking habits. From the histological point of view, such histotype is characterized by keratinization.…”

Section: Histopathologymentioning

confidence: 99%

Ion channels in lung cancer: biological and clinical relevance

Capitani,

Chioccioli Altadonna,

Santillo

et al. 2023

Front. Pharmacol.

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“…Non-small-cell lung cancer (NSCLC) is the second most common cancer worldwide, resulting in 2 million diagnoses and 1.8 million deaths per year [1,2]. The most important risk factor for NSCLC is cigarette smoke because of its carcinogenic chemicals [3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of potential predictive biomarkers for defining brain radiotherapy efficacy in NSCLC patients with brain me-tastases: A case report and review of literature

Luciano¹,

Liguori²,

Polcaro³

et al. 2023

Preprint

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Non-small-cell lung cancer (NSCLC) is the second most common cancer worldwide, resulting in 1.8 million deaths/year. Most of the patients are diagnosed with a metastatic disease. Central Nervous System is one of the major metastatic sites. Brain metastases are associated with severe neurological symptoms, shorter survival and worst clinical outcomes. Brain radiotherapy and systemic oncological therapies are currently used for controlling both cancer progression and neurological symptoms. Brain radiotherapy includes stereotactic brain ablative radiotherapy (SBRT) or whole brain radiotherapy (WBRT). SBRT is applied for single or multiple (≤ 4) small lesions (&lt; 3 cm), while WBRT represents the best treatment choice in case of multiple and large brain metastases. In both cases radiotherapy application can represent an overtreatment causing severe toxicities without achieving a significant clinical benefit. So far, some scores have been proposed to define the potential clinical benefits derived from brain radiotherapy. However, most of them are not well validated into clinical practice. In this article, by presenting a clinical case of a patient with advanced NSCLC carrying a BRAFV600E mutation and brain metastases, we review the variables as well as the potential applicable scores to be considered in order to predict clinical outcomes and benefits from brain radiotherapy in patients with NSCLC and brain metastases.

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“…[9] Studies have reported that its incidence has increased significantly and is likely to show an upward trend over the next few decades. [10][11][12][13][14][15] There were 2,206,771 new LC patients and 1,796,144 LC mortality in 2020. [4] Of those, most patients with LC have a limited life span.…”

Section: Introductionmentioning

confidence: 99%

Effects of psychological nursing care on anxiety and depression in perioperative patients with lung cancer: A systematic review and meta-analysis

et al. 2022

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Background: This study aimed to investigate the effects of psychological nursing care (PNC) on anxiety relief in perioperative lung cancer (LC) patients. Methods: We searched the Cochrane Library, PubMed, Embase, CNKI, CBM, and Wangfang electronic databases from inception to May 1, 2022. Eligible randomized controlled trials (RCTs) investigating the effects and safety of PNC on anxiety relief in perioperative LC patients. Anxiety was the primary outcome measure. The secondary outcomes were depression, length of hospital stay, and the occurrence of adverse events. Results: Six eligible RCTs with 494 patients were included in this study. Compared with routine nursing care, PNC showed better outcomes in terms of anxiety relief (mean difference [MD] = –13.24; random 95% confidence interval (CI), –18.28 to –8.20; P<.001), depression decrease (MD = –11.84; random 95% CI, –18.67 to –5.01; P < .001), and length of hospital stay (MD = –2.6; fixed 95% CI, –3.13 to –2.07; P < .001). No data on adverse events were pooled because only 1 trial reported this outcome. Conclusions: This study showed that PNC may benefit more than routine nursing care for patients with LC in anxiety, depression, and length of hospital stay. High-quality RCTs are needed to validate the current findings in the future.

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Incidence and Prevalence Analysis of Non-Small-Cell and Small-Cell Lung Cancer Using Administrative Data

Cited by 10 publications

References 19 publications

Ion channels in lung cancer: biological and clinical relevance

Ion channels in lung cancer: biological and clinical relevance

Evaluation of potential predictive biomarkers for defining brain radiotherapy efficacy in NSCLC patients with brain me-tastases: A case report and review of literature

Effects of psychological nursing care on anxiety and depression in perioperative patients with lung cancer: A systematic review and meta-analysis

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