Incidence and Prevalence of Adult Coeliac Disease within a Defined Geographic Area in Denmark

Bodé, Susan; Gudmand-Høyer, E

doi:10.3109/00365529609009152

Cited by 44 publications

(27 citation statements)

References 31 publications

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“…In Denmark, prevalence rates around 1:10,000 have been reported from paediatric studies [19,20]. However, serological studies among 1573 Danish blood donors indicated a prevalence of 1:394.…”

Section: Discussionmentioning

confidence: 98%

Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients

Fluge

Olesen

Gilljam

et al. 2009

Journal of Cystic Fibrosis

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Section: Discussionmentioning

confidence: 98%

Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients

Fluge

Olesen

Gilljam

et al. 2009

Journal of Cystic Fibrosis

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“…Soon it became easy to make a specific diagnosis in clinical practice, while a device was in infancy. Except in Sweden, most celiac disease patients will today be detected in adulthood [18,19]. developed to take a biopsy by swallowing a special capsule [3].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features of Celiac Disease Today

Collin

Kaukinen

Mäki³

1999

Dig Dis

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The clinical spectrum of celiac disease has widened over the past decades. The condition is no longer a severe malabsorption syndrome. Instead, a typical celiac disease patient today has merely mild abdominal symptoms. Malabsorption can be subclinical or absent, and there is usually only moderate, if any, loss of weight. Simultaneously, the current prevalence has increased from 1:1,000 to 1:300 inhabitants, or even higher. Clinically silent celiac disease cases are being detected in increasing numbers since the introduction and widespread use of serologic screening tests. Symptoms of celiac disease can appear outside the intestine, a typical example being dermatitis herpetiformis. Gluten intolerance is no longer limited to overt villous atrophy. Inflammation without villous damage may be observed in genetically susceptible individuals. The term latent celiac disease is applied in situations where the patient has normal villous architecture while on a gluten-containing diet, but later develops small bowel villous atrophy compatible with celiac disease.

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“…In Denmark, the prevalence of recognized cases of celiac disease in the general population is very low compared with the prevalence in other neighboring countries (4,5). On the other hand, a high incidence of childhood type 1 diabetes has been documented (6).…”

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confidence: 99%

Clinical Benefit of a Gluten-Free Diet in Type 1 Diabetic Children With Screening-Detected Celiac Disease

et al. 2006

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OBJECTIVE—This study was performed to 1) determine the prevalence of celiac disease in Danish children with type 1 diabetes and 2) estimate the clinical effects of a gluten-free diet (GFD) in patients with diabetes and celiac disease. RESEARCH DESIGN AND METHODS—In a region comprising 24% of the Danish population, all patients <16 years old with type 1 diabetes were identified and 269 (89%) were included in the study. The diagnosis of celiac disease was suspected in patients with endomysium and tissue transglutaminase antibodies in serum and confirmed by intestinal biopsy. Patients with celiac disease were followed for 2 years while consuming a GFD. RESULTS—In 28 of 33 patients with celiac antibodies, an intestinal biopsy showed villous atrophy. In 5 patients, celiac disease had been diagnosed previously, giving an overall prevalence of 12.3% (95% CI 8.6–16.9). Patients with celiac disease had a lower SD score (SDS) for height (P < 0.001) and weight (P = 0.002) than patients without celiac disease and were significantly younger at diabetes onset (P = 0.041). A GFD was obtained in 31 of 33 patients. After 2 years of follow-up, there was an increase in weight SDS (P = 0.006) and in children <14 years old an increase in height SDS (P = 0.036). An increase in hemoglobin (P = 0.002) and serum ferritin (P = 0.020) was found, whereas HbA1c remained unchanged (P = 0.311) during follow-up. CONCLUSIONS—This population-based study showed the highest reported prevalence of celiac disease in type 1 diabetes in Europe. Patients with celiac disease showed clinical improvements with a GFD. We recommend screening for celiac disease in all children with type 1 diabetes.

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Incidence and Prevalence of Adult Coeliac Disease within a Defined Geographic Area in Denmark

Cited by 44 publications

References 31 publications

Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients

Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients

Clinical Features of Celiac Disease Today

Clinical Benefit of a Gluten-Free Diet in Type 1 Diabetic Children With Screening-Detected Celiac Disease

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