Incidence and prevalence of childhood‐onset Type 1 diabetes in Japan: the T1D study

Onda, Yoshiko; Sugihara, Shigetaka; Ogata, Tsutomu; Yokoya, Susumu; Yokoyama, Tetsuji; Tajima, Naoko

doi:10.1111/dme.13295

Cited by 58 publications

(51 citation statements)

References 29 publications

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“…For example, the upward trend in mean body mass index (BMI) has recently flattened in northwestern Europe, which exactly coincides with the stabilization of the incidence trend for T1D observed in Ireland and northern Europe . Furthermore, higher incidence of childhood respiratory tract infections caused by certain microbes yet to be determined has been noted mainly in winter (eg, an approximation of 4.8/person‐years in winter months, more than twofolds higher than that in summer months), which is in parallel with the seasonal pattern that higher frequencies of T1D diagnosis occur in cold season …”

Section: Introductionmentioning

confidence: 58%

“…By contrast, stabilization after years of the upward trend has been observed since the first decade of 21st century, mainly in regions already presenting high T1D incidences such as the 3 Nordic countries described above, Ireland, Czech, Biscay, Sardinia, Saudi Arabia, and Western Australia . Besides, incidences in 2 Asian regions with low risk for T1D, Taiwan and Japan, are holding steady as well. The flattening of T1D incidence trend observed in 4 countries (regions) between 2000 and 2010 is shown in Figure .…”

Section: Epidemiologymentioning

confidence: 98%

“…Next come countries in southeast Europe which usually manifest a moderate risk for T1D with incidences around 10/100 000 person‐years. Last, but not least, incidences as low as 1 to 5 cases/100 000 person‐years are not uncommon in Latin America, Africa, and Asia …”

Section: Epidemiologymentioning

confidence: 99%

“…T1D was initially recognized as a chronic disease among children and young adolescents, but over time, the perspective that T1D can occur at any age has been gradually accepted . The incidence of childhood T1D has been growing globally since the past few decades though stagnation has also been observed in a small number of regions around the world …”

Section: Introductionmentioning

confidence: 99%

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Incidence and trend of type 1 diabetes and the underlying environmental determinants

Xia

Xie

Huang

et al. 2018

Diabetes Metabolism Res

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A wealth of epidemiological studies concerning the distribution of type 1 diabetes (T1D) around the world have pointed to the appreciable variation in the incidence of T1D among disparate age groups, ethnicities, and geographical locations. On the whole, the incidence of childhood T1D has been on the rise, and a plausible inverse relationship between the initial incidence rate and the following annual increase in incidence has been raised. Countries that used to exhibit lower incidences tend to have steep annual increase whereas those with already-established high incidences are more likely to show a modest increase or even stabilization in T1D incidence. Environmental agents considered responsible for the current evolving pattern of T1D incidence will be detailed, mainly including the increasing prevalence of childhood obesity, viral infections in a chronic manner, maternal-child interaction such as breastfeeding, and latitude-ultraviolet B-vitamin D pathway. Certain rationale has been put forward in an attempt to explain the potential association between environmental agents and development of T1D. For instance, accelerator hypothesis regards insulin resistance as the promoter of earlier disease onset in obese children whereas the negative correlation of microbial infections in background populations with incidence of T1D represents the basic component of the hygiene hypothesis. Further investigations are still warranted to verify these theories across multiple ethnic groups and to identify additional contributors to the variation in T1D incidence.

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Section: Introductionmentioning

confidence: 58%

Section: Epidemiologymentioning

confidence: 98%

Section: Epidemiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incidence and trend of type 1 diabetes and the underlying environmental determinants

Xia

Xie

Huang

et al. 2018

Diabetes Metabolism Res

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“…First, the cohort comprised both patients with type 1 and type 2 diabetes, although the majority are likely to have had type 2 diabetes because the incidence of type 1 diabetes is very low in Japan (2.25/10 5 ) [30]. Second, our study has the possibility of selection bias because medical institutes that have a particular interest in diabetes care may have participated more frequently.…”

Section: Discussionmentioning

confidence: 99%

Twelve-year trends of increasing overweight and obesity in patients with diabetes: the Shiga Diabetes Clinical Survey

et al. 2018

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Abstract. The prevalence of obesity is increasing globally in patients with diabetes. This study aimed to examine 12-year trends of increasing obesity in Japanese patients with diabetes, and their clinical features. The study used results of the Shiga Diabetes Clinical Survey, which recorded medical performance in diabetic patients in 2000, 2006 and 2012. Data were analyzed from 14,205, 14,407 and 21,449 adult patients in these three years, respectively. Overweight and obesity prevalence and the clinical features of diabetes patients were examined, stratified by body mass index (BMI) and age. The prevalence of overweight (BMI 25-30 kg/m 2 ) and obesity (BMI ≥30 kg/m 2 ) were 27.0% and 5.1% in 2000, 28.9% and 7.3% in 2006 and 30.9% and 10.0% in 2012. Glycemic control, blood pressure and serum lipid profile improved over 12 years in all BMI categories. However, glycemic and triglyceride control were insufficient in obese patients aged <65 years (hemoglobin A1c 7.5 ± 1.4%, triglyceride 197.7 ± 178.4 mg/dL in 2012). The percentage of patients who used antihypertensive and lipidlowering drugs increased and patients with higher BMI had increased frequency of using these drugs, both in young and old age groups. Higher BMI was significantly and positively associated with albuminuria. In summary, overweight and obesity have increased in Japanese diabetic patients, particularly for younger generations. Findings suggest that obesity may lead to poorer glycemic control, blood pressure and lipid profiles. Overweight and obesity are important modifiable risk factors for diabetes, suggesting that more active weight-control interventions are warranted.

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Epidemiology of Type 1 Diabetes

Stene,

Tuomilehto

2024

Textbook of Diabetes

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Incidence and prevalence of childhood‐onset Type 1 diabetes in Japan: the T1D study

Cited by 58 publications

References 29 publications

Incidence and trend of type 1 diabetes and the underlying environmental determinants

Incidence and trend of type 1 diabetes and the underlying environmental determinants

Twelve-year trends of increasing overweight and obesity in patients with diabetes: the Shiga Diabetes Clinical Survey

Epidemiology of Type 1 Diabetes

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