Background
The degree of effectiveness of condoms in preventing the transmission of herpes simplex virus 2 (HSV-2), is uncertain. We performed a large pooled analysis to address this question.
Methods
We identified prospective studies with individual-level condom use data and laboratory-defined HSV-2 acquisition. Six studies were identified through a review of publications through 2007: three candidate HSV-2 vaccine studies, an HSV-2 drug study, an observational STD incidence study and a behavioral STD intervention study. Study investigators provided us individual-level data to perform a pooled analysis. Effect of condom use was modeled using a continuous percent of sex acts during which a condom was used and, alternatively, using absolute number of unprotected sex acts.
Results
A total of 5384 people who were HSV-2 negative at baseline contributed 2,040,894 follow-up days. 415 persons acquired laboratory-documented HSV-2 during follow-up. Consistent (100%) condom users had a 30% lower risk of HSV-2 acquisition compared to those who never used condoms (hazard ratio: 0.70; 95 percent confidence interval: 0.40, 0.94; p = 0.01). Risk for HSV-2 acquisition increased steadily and significantly with each unprotected sex act (hazard ratio: 1.16; 95 percent confidence interval: 1.08, 1.25); p < 0.001). Condom effectiveness did not vary by gender.
Conclusions
This is the largest analysis using prospective data to assess the effect of condoms in preventing HSV-2 acquisition. Although the magnitude of protection was not as large as has been observed with other STIs, we found that condoms offer moderate protection against HSV-2 acquisition in men and women.