Incidence and progression of diabetic retinopathy in Japanese adults with type 2 diabetes: 8 year follow-up study of the Japan Diabetes Complications Study (JDCS)

Abstract

Aims/hypothesis The aim of this study was to determine the incidence and progression rates of diabetic retinopathy and their associations in Japanese individuals with type 2 diabetes. Methods This is a part of the Japan Diabetic Complications Study (JDCS), a multi-centred randomised trial of type 2 diabetes patients aged 40-70 years with an 8 year followup. There were 1,221 patients without diabetic retinopathy at baseline; incidence of diabetic retinopathy was defined as the development of any diabetic retinopathy. There were 410 patients with mild non-proliferative diabetic retinopathy at baseline; progression of diabetic retinopathy was defined as the development of severe non-proliferative diabetic retinopathy or proliferative diabetic retinopathy.We used multivariate proportional Cox hazard models, and generalised additive models were also applied to identify potential threshold effect.

Risk of Cardiovascular Diseases Is Increased Even with Mild Diabetic Retinopathy

“…13,14 In brief, the JDCS is a multicenter, open-labeled, randomized trial of type 2 diabetic patients examining the impact of lifestyle intervention on diabetic complications. In 1996, 2033 adults Japanese persons (age range, 40 -70 years) with type 2 diabetes whose hemoglobin A1c (HbA1c) levels were 6.5% or more were enrolled and randomized; primary outcome analyses have been reported elsewhere.…”

Possible role of endostatin in the antiangiogenic therapy of diabetic retinopathy

“…Numerous data accounts have been presented after researches on various populations [3]. According to a study conducted on 18,891 people (of all age groups) suffering from type I diabetes mellitus, there was an observation that, after suffering from diabetes for 40 years, 50.2% of the patients presented with advanced diabetic retinopathy and 84.1% of the patients suffered from some kind of primitive stages of diabetic retinopathy [26].…”

Diabetes Mellitus and Retinal Vein Occlusion as Risk Factors for Open Angle Glaucoma and Neuroprotective Therapies for Retinal Ganglion Cell Neuropathy

“…The report from the International Diabetes Federation estimated that people with diabetes in the Asian Pacific region will increase from 137 million in 2010 to 214 million by 2030 [6]. According to the study performed by Kawasaki et al as part of the Japan Diabetic Complications Study, the incidence of DR is 38.3/1,000 person-years and the progression rate is 21.1/1,000 person-years [7].…”

“…The average intraocular pressure (IOP) in patients with POAG is 15.4 ± 2.8 mmHg, which is significantly higher than that of normal subjects (14.5 ± 2.5 mmHg) [1][2][3][4][5][6][7][8][9][10] even though the average difference in the IOP is only 0.9 mmHg. Thus, a reduction of the IOP the standard therapy for glaucoma may not be sufficient for the complete management of the patients with glaucoma in Japan.…”