Incidence and Recurrence of Allergic Fungal Sinusitis at Tertiary Care Facility

Tanveer, Uzma; Gul, Amna; Aqil, Shakil

doi:10.1007/s12070-017-1218-y

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…The main symptoms of patients with AFRS in our study were nasal obstruction and headache. This finding is similar to another study that was conducted from January 2011 to December 2015 at the Liaquat National Hospital, which reported that the common presenting symptoms of AFRS included nasal obstruction, headache, nasal discharge, and proptosis [14].…”

Section: Discussionsupporting

confidence: 90%

The Rate and Predictors of Allergic Fungal Rhinosinusitis Recurrence Post-sinus Surgery: A Retrospective Cohort Study

Alfattani¹,

Alqurashi²,

Kabli³

et al. 2023

Cureus

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ObjectivesChronic rhinosinusitis (CRS) is the persistent inflammation of the mucosal lining of the paranasal sinuses (PNS). By definition, the inflammatory process persists beyond 12 weeks. One of its subtypes is allergic fungal rhinosinusitis (AFRS), which has a high risk of recurrence, leading to revision surgery. This study aimed to establish the predictive factors for the recurrence of AFRS in post-sinus surgery patients. MethodsThis single-center retrospective study was conducted in Al-

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Section: Discussionsupporting

confidence: 90%

The Rate and Predictors of Allergic Fungal Rhinosinusitis Recurrence Post-sinus Surgery: A Retrospective Cohort Study

Alfattani¹,

Alqurashi²,

Kabli³

et al. 2023

Cureus

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“…Our choice was based on clinical importance, given the high recurrence rate of AFRS and the treatment challenges faced by these patients. [ 19 ] To date, studies similar to ours, reporting the prevalence of AFRS among fungal rhinosinusitis, are scarce. Moreover, the variation in the prevalence reported in previous studies and ours could potentially be explained by weather conditions as climate can contribute to fungal growth.…”

Section: Discussionmentioning

confidence: 85%

“…In addition, the use of biologic therapies targeting specific pathways in type 2 inflammation, such as omalizumab (anti-IgE), mepolizumab, and dupilumab, remains somewhat controversial, despite demonstrating promise in AFRS treatment. [19] In our efforts to examine the differences between patients with AFRS and those without AFRS, as well as between patients with local and systemic AFRS, we found that while distinguishing between patients with and without AFRS may be relatively straightforward, classifying systemic and local allergic reactions in AFRS patients can be challenging. Relying solely on clinical signs and symptoms may not suffice for this classification.…”

Section: Discussionmentioning

confidence: 99%

Manifestation and associated factors of systemic and local allergy among patients with allergic fungal rhinosinusitis: An observational study

Vo,

Thai,

Pham

et al. 2024

Medicine

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Allergic fungal rhinosinusitis (AFRS) is a subtype of chronic rhinosinusitis, characterized by excessive immune responses to environmental molds or fungi. The diagnosis and classification of AFRS into systemic and local types remain clinically challenging due to overlapping characteristics. This study investigated the prevalence of AFRS, its manifestation and associated factors in systemic and local AFRS. A total of 200 patients diagnosed with fungal rhinosinusitis underwent both skin provocation tests (SPT) and nasal provocation tests (NPT) to confirm AFRS and classify systemic and local types. Patients were considered to have AFRS if either the SPT or NPT was positive. Among these, patients with systemic AFRS were those who had a SPT positive. Local AFRS was when patients had a negative SPT and a positive NPT. Medical history, serum total IgE level, nasal endoscopy examinations, and CT scans were also recorded. Most patients were female (65.8%), with a mean age of 55.6 years (SD = 14.4). Based on the SPT and NPT results, 31% of patients (n = 62) were diagnosed with AFRS. Among these, 54.8% (n = 34) had systemic AFRS, while 45.2% (n = 28) had local AFRS. Patients with AFRS exhibited significantly higher levels of total IgE, eosinophils, and more pronounced signs and symptoms compared to those without AFRS. However, no statistically significant differences were observed between patients with systemic AFRS and those with local AFRS. AFRS was prevalent in our study. Among patients with AFRS, both systemic AFRS and local AFRS were also prevalent. While allergic indicators and clinical presentations can aid in AFRS diagnosis, minimal distinctions were observed between systemic and local AFRS. A comprehensive assessment incorporating both local and systemic allergic responses through provocation tests, such as a combination of skin and nasal tests, is imperative for optimizing AFRS diagnosis and management.

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“…The incidence of allergic fungal sinusitis varies in different geographical settings. In Pakistan, its incidence is 18.9%, which happens to be higher than UK and Saudi Arabia that is 4% and 12.1% respectively [15]. India on the other hand has higher incidence of 56%-57% [16,17].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of CT scans in allergic fungal sinusitis: A cross sectional study

Mughal¹

2022

J Clin Images Med Case Rep

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Fungal sinusitis, with passage of time, has become one of the common entities among a long list of inflammatory diseases involving mucosa of the sinonasal tract [1]. By definition, AFS is a collection of cellular debris and mucus in result of an allergic response to fungal colonization in sinus mucosa [2]. The patients are young, atopic with good immunity suffering from nasal blockage, congestion, nasal discharge (purulent or watery), anosmia or headache for several years [1]. On clinical examination nasal polyps are seen [3,4]. The causative organisms are vastly from species of Aspergillus but dermatiaceous fungi are also seen such as Bipolaris, Alternaria, Curvularia and Fusarium [5].

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Incidence and Recurrence of Allergic Fungal Sinusitis at Tertiary Care Facility

Cited by 5 publications

References 19 publications

The Rate and Predictors of Allergic Fungal Rhinosinusitis Recurrence Post-sinus Surgery: A Retrospective Cohort Study

The Rate and Predictors of Allergic Fungal Rhinosinusitis Recurrence Post-sinus Surgery: A Retrospective Cohort Study

Manifestation and associated factors of systemic and local allergy among patients with allergic fungal rhinosinusitis: An observational study

Diagnostic accuracy of CT scans in allergic fungal sinusitis: A cross sectional study

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