Incidence and Residual Risk of HIV, HBV and HCV Infections Among Blood Donors in Tehran

Saber, Hamid Reza; Tabatabaee, Seyed Morteza; Abasian, A.; Jamali, Mostafa; SalekMoghadam, Ebadollah; Hajibeigi, Bashir; Alavian, Seyed Moayed; Mirrezaie, Seyed Mohammad

doi:10.1007/s12288-016-0732-5

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…In conclusion, using donation data from five Chinese regional blood centers, we provide a robust estimation of HCV prevalence in first‐time donors and HCV incidence among repeat blood donors. Our findings suggest that the HCV prevalence and incidence among blood donors in China are higher than in developing as well as developed countries (incidence of 1, 1.58, 5, 2.65, and 6.91 in 100,000 person in Canada in 2012‐2014, Italy in 2015, the United States in 1999‐2008, Brazil in 2012‐2014, and Tehran in 2005‐2010, respectively) . Continued strong efforts and surveillance are still needed to monitor and control the risk of transfusion‐transmitted HCV transfusion in China.…”

Section: Discussionmentioning

confidence: 82%

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

Lv²,

Zhang³

et al. 2019

Transfusion

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were screened in parallel by two different enzyme-linked immunosorbent assays for anti-HIV 1/2, hepatitis B surface antigen, anti-HCV, and syphilis. Screeningreactive samples were further confirmed by western blot. Confirmatory positive rates among first-time and repeat donors were used to estimate the prevalence and incidence rates. Multivariable logistic regression modeling was used to examine factors associated with HCV infection. RESULTS:A total of 1,276,544 donations were collected from five Chinese blood centers, of which an estimated 1203 were confirmed HCV positive. The overall HCV prevalence among first-time donors was 166.56 per 100,000 donors (95% confidence interval, 156.04-177.08). The HCV incidence rate was estimated to be 15.21 (95% confidence interval, 11.83-19.56) per 100,000 person-years among repeat donors. Multivariable logistic regression results showed that increased age, lower educational levels, ethnicity, and occupation were all important factors associated with HCV confirmatory status among first-time donors (p < 0.01). CONCLUSIONS: HCV infection is still an importantconcern for transfusion safety in China. Our findings indicate that continued strong efforts are needed to monitor and control the risk of transfusion-transmitted HCV infection in China. Moreover, to reduce unnecessary donor loss, HCV donor screening procedures should be improved by incorporating confirmatory testing into routine blood center operations. From the

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Section: Discussionmentioning

confidence: 82%

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

Lv²,

Zhang³

et al. 2019

Transfusion

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“…Poorer countries, however, tend to have more first‐time donors. In Tehran, 40% of the blood comes from first‐time donors and these donations were excluded from their incidence calculations [19]. Zimbabwe similarly collects 44% of the blood from first‐time donors [20]; however, they estimated RR in first‐time donations by modifying the I/WP model; instead of using the inter‐donation interval of a seroconverting repeat donor, they substituted the prevalence and duration of asymptomatic WHO stages 1 and 2 of 5 years [21].…”

Section: Discussionmentioning

confidence: 99%

HIV incidence in South African blood donors from 2012 to 2016: a comparison of estimation methods

et al. 2020

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Background Measuring incidence is important for monitoring and maintaining the safety of the blood supply. Blood collected from repeat‐donors has provided the opportunity to follow blood donors over time and has been used to estimate the incidence of viral infections. These incidence estimates have been extrapolated to first‐time donors using the ratio of NAT yield cases in first‐time versus repeat‐donors. We describe a model to estimate incidence in first‐time donors using the limiting antigen (LAg) avidity assay and compare its results with those from established models. Methods HIV‐positive first‐time donations were tested for recency using the LAg assay. Three models were compared; incidence estimated for (1) first‐time donors using LAg avidity, (2) first‐time and repeat‐donors separately using the NAT yield window period (WP) model and (3) repeat‐donors using the incidence/WP model. Results HIV incidence in first‐time donors was estimated at 3·32 (CI 3·11, 3·55) and 3·81 (CI 3·07, 4·73) per 1000 PY using the LAg assay and NAT yield WP models, respectively. Incidence in repeat‐donors was between 2·0‐ and 2·5‐fold lower than in first‐time donors estimated at 1·56 (CI 1·37, 1·77) and 1·94 (CI 1·86–2·01) per 1000 PY using the NAT yield/WP and incidence/WP models, respectively. Conclusion Testing HIV‐positive donations using the LAg assay provides a reliable method to estimate incidence in first‐time donors for countries that collect the majority of blood from first‐time donors and do not screen with NAT.

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“…Given the significance of these infections and the ease with which they are transmitted through blood products, the IBTO follows a set of standard operation procedures (SOPs) to identify infected blood donations and prevent their use. These procedures include two main activities: selecting safe donors and performing screening tests in order to identify TTIs 8…”

Section: Introductionmentioning

confidence: 99%

<p>The Trends of Viral Hepatitis B and C and HIV Infections in Donated Bloods in Iran Between 2003 and 2017</p>

Soodejani

Haghdoost

Sedaghat

et al. 2019

JBM

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BackgroundThe rate of viral infections in donated bloods is one of the main indicators of blood safety which has to be monitored precisely. This paper provides a thorough study of blood safety indicators in the last 15 years in Iran.MethodsThe data of the transfusion organization in Iran from years 2003 to 2017 were used. The study focuses on the analysis of the frequency of viral hepatitis B and C (HBV and HCV) as well as human immunodeficiency virus (HIV) in blood donations.ResultsOf 27,442,124 donated bloods, the relative frequencies were 4, 302, and 81 for HIV, HBV and HCV, respectively. This study also shows that the corresponding frequencies were significantly lower in recent years (2.5, 53, and 26 per 100,000 samples in 2017).ConclusionThe presented study indicates an overall low infection rate and provides evidence for the effectiveness of modern safety measures in improving the level of blood safety in Iran.

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Incidence and Residual Risk of HIV, HBV and HCV Infections Among Blood Donors in Tehran

Cited by 6 publications

References 17 publications

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

HIV incidence in South African blood donors from 2012 to 2016: a comparison of estimation methods

<p>The Trends of Viral Hepatitis B and C and HIV Infections in Donated Bloods in Iran Between 2003 and 2017</p>

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