Incidence and Risk Factors for Gout in White Men

Roubenoff, Ronenn; Klag, Michael J.; Mead, Lucy A.; Liang, Kung Yee; Seidler, Alexander J.; Hochberg, Marc C.

doi:10.1001/jama.1991.03470210072035

Cited by 208 publications

(145 citation statements)

References 11 publications

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“…On the other hand, one claims that insulin resistance causes consistent increase of concentration of adenosine, which leads to increase in uric acid, resulting in hyperuricemia [31]. In addition, it is well known that weight loss reduces production of uric acid, and obesity has close relation with hyperuricemia and attack of gouty arthritis [32,33], and abdominal obesity is an important risk factor to occurrence of insulin resistance [34,35]. This study showed positive linear relationship between the amounts of 24-h uric acid excretions and insulin resistance (r 2 = 0.271, P = 0.017).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis

Yoo

Chae

et al. 2009

Rheumatol Int

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The study was performed to confirm the high prevalence of metabolic syndrome in gouty patients and to define the relationship between insulin resistance and gouty arthritis. We recruited 83 patients with gouty arthritis and checked clinical factors according to the diagnostic criteria of metabolic syndrome from the ATP III guidelines and WHO Asia-Pacific obesity criteria recommendations. We also assessed the clinical characteristics of subjects and homeostasis model assessment of insulin resistance (HOMA-IR) and compared with previous study groups as controls. The prevalence of metabolic syndrome in patients with gout was 30.1% according to ATP III criteria and 50.6% with WHO Asia-Pacific adjustment and is significantly higher than the previous control study groups (ATP III: 5.2, 10.6%, WHO Asia-Pacific adjustment: 9.8, 13.9%). The mean value of HOMA-IR in patients with gout was 2.63 ± 1.36 and is significantly higher than control study (1.91 ± 1.01, P < 0.05). There were significant correlations between 24-h urinary uric acid excretion and waist circumference (r(2) = 0.225, P = 0.049), fasting insulin (r(2) = 0.241, P = 0.035), and insulin resistance (HOMA-IR) (r(2) = 0.271, P = 0.017). There were significant correlations between insulin resistance and waist circumference (r(2) = 0.341, P < 0.01), BMI (r(2) = 0.390, P < 0.01). The value of HOMA-IR (insulin resistance) and the prevalence of metabolic syndrome in patients with gout are significantly higher than normal healthy control groups. The hyperuricemia in gout might be caused by the increased adiposity associated with insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis

Yoo

Chae

et al. 2009

Rheumatol Int

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“…The eects of obesity, hypertriglyceridemia, and alcohol consumption have previously been studied [1,2].…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia in Saudi Arabia

Al-Arfaj

2001

Rheumatology International

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The objective of this prospective study was to determine the prevalence of hyperuricemia and gout in a sample of Saudi individuals and their relationship to certain risk factors, namely, obesity, serum glucose, triglycerides, cholesterol, age, and sex. A total of 487 Saudis (250 males and 237 females) from 14 primary care clinics were interviewed, examined, and investigated. The mean age for the males was 46.89 +/- 17.01 years (range 14-83) and for the females 45.08 +/- 13.67 years (range 21-80). Serum uric acid (SUA) values above 420 micromol/l for males and 360 micromol/l for females were considered to be high. Of the 487 individuals, 41 (8.42%; 20 males and 21 females) had hyperuricemia. The mean SUA was 308.41 +/- 90.64 micromol/l for males and 254.59 +/- 85.79 micromol/l for females. In females, uric acid levels correlated significantly with age, body mass index (BMI), serum creatinine, and the erythrocyte sedimentation rate (ESR), but not with serum cholesterol or triglycerides. In males, uric acid levels only correlated significantly with BMI and serum creatinine. No case of gout was found.

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“…Among men in the Framingham Study [9], the overall gout incidence rate was 1.6 cases per 1000. Roubenoff et al [14], using patient self-report, observed a similar incidence rate (1.7 cases per 1000 patient-years) among male participants in the Johns Hopkins Precursors Study, a prospective cohort study involving medical students. In comparison, gout incidence among otherwise healthy male Veterans over a 15-year follow-up period was found to be 2.8 cases per 1000 patient-years [15].…”

Section: Incidencementioning

confidence: 80%

“…Excessive weight gain in young adulthood is also a risk factor independent of obesity [14]. Similarly, a reduction in weight may also lower gout risk [42].…”

Section: Obesitymentioning

confidence: 99%

Recent advances in the epidemiology of gout

Mikuls

2005

Curr Rheumatol Rep

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Gout remains among the most common of all inflammatory arthridities with an incidence that appears to have risen. Evidence is accumulating to support lifestyle and dietary factors, such as heavy consumption of beer and liquor as well as diets rich in meats and seafood as important gout risk factors. There is also a renewed interest in important associations between gout and other comorbidities like hypertension and cardiovascular disease. The importance of hyperuricemia on health considerations beyond the musculoskeletal system is an area worthy of even more study.

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Incidence and Risk Factors for Gout in White Men

Cited by 208 publications

References 11 publications

Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis

Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis

Hyperuricemia in Saudi Arabia

Recent advances in the epidemiology of gout

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