Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea

Lee, Jeong Eun; Lee, Shinwon; Song, Sang Heon; Kwak, Ihm Soo; Lee, Sun Hee

doi:10.3904/kjim.2016.418

Cited by 11 publications

(21 citation statements)

References 18 publications

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“…We also found a low prevalence of renal impairment among study participants. is finding was consistent with findings in South Africa (7.6%) [13] and Malaysia 9.3% [17], lower than in Korean (14.4%) [22] and Japan (22.1%) [12], and higher than in Spain (4-5%) [23].…”

Section: Discussionsupporting

confidence: 92%

“…In this study, we used the Kidney Disease Outcomes Quality Initiative (KDOQI) of the National Kidney Foundation to clarify the eGFR (ml/min/1.73 m 2 ) group including 6 stages (stage 1 (>90), stage 2 (60-89), stage 3a (45-59), stage 3b (30-44), stage 4 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), and stage 5 (<15)).…”

Section: Demographic Collectionmentioning

confidence: 99%

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Determinants of Risk Factors for Renal Impairment among HIV‐Infected Patients Treated with Tenofovir Disoproxil Fumarate‐Based Antiretroviral Regimen in Southern Vietnam

Hoang

Nguyen

et al. 2020

BioMed Research International

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Background. The situation of renal impairment among HIV-infected patients treated with TDF-based antiretroviral (ARV) regimen greater than 3 years is little known when TDF use has been promptly increasing in Vietnam. Methods. We analyse demographic and clinical data from a cross-sectional survey of 400 HIV-infected patients aged ≥18 years, who were treatment-naive or switched TDF regimen within over 3 years between November 2018 and March 2019. Serological tests for serum creatinine, ALT, and AST were performed. Renal impairment was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Multivariate regression analyses were used to explore the risk factors associated with renal impairment. Results. At the baseline, 7.8% of respondents had estimated glomerular filtration rate (eGFR) of 30–59 mL/min/1.73 m2 and 0.8% had eGFR of 15–29 mL/min/1.73 m2, out of 34 (8.5%) of participants who had renal impairment. Multivariate analysis showed that participants who had preexposure to isoniazid (adjusted PR [aPR] = 0.35 Cl: 0.14–0.91) compared with nonexposure to isoniazid who had a BMI from 18.5 up to 25 kg/m2 (aPR = 0.31 Cl: 0.15–0.62) compared with BMI below 18.5 kg/m2 were less likely to suffer from renal impairment. Patients aged greater than 60 years (aPR = 26.75, 95% Cl: 3.38–211.62) compared with those aged 20–29 years were more likely to have increased risk of renal impairment. Conclusion. Our findings underscore the need for longitudinal studies to assess the influence of TDF on maintaining the low prevalence of renal impairment among HIV-infected patients in Vietnam.

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Section: Discussionsupporting

confidence: 92%

Section: Demographic Collectionmentioning

confidence: 99%

Determinants of Risk Factors for Renal Impairment among HIV‐Infected Patients Treated with Tenofovir Disoproxil Fumarate‐Based Antiretroviral Regimen in Southern Vietnam

Hoang

Nguyen

et al. 2020

BioMed Research International

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“…The re-sults are discrepant to the ones from 2011 in which urine protein excretion was higher in patients treated with tenofovir. Similarly, Lee et al [29] in their retrospective study did not show higher rates of renal dysfunction in patients treated with tenofovir compared to other regimens. Frequent medical check-ups and monitoring of renal function performed as part of antiretroviral therapy allow rapid intervention and cART regimen changes as required.…”

Section: Discussionmentioning

confidence: 77%

Concentration of selected low molecular-weight proteins in urine – a retrospective analysis of chronic kidney disease among HIV patients receiving antiretroviral therapy

Marchewka¹,

Szymańska²,

Domagała³

et al. 2019

HIV & AIDS Review

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Introduction: Human immunodeficiency virus (HIV) infection remains an important health problem despite the fact that combined antiretroviral therapy (cART) prolongs life and protects against acquired immunodeficiency syndrome (AIDS). Chronic kidney disease is an important cause of mortality among HIV patients, co-monitoring of renal function and modifying factors such as cART require constant analysis. The aim of this study was a retrospective analysis of renal function among HIVinfected and cART-treated patients by measuring urine concentrations of chosen low molecular weight proteins (LMWP) as biomarkers of kidney dysfunction: retinol-binding protein (RBP), β 2-microglobulin (β 2 M), and neutrophil gelatinase-associated lipocalin (NGAL). The results were compared with those obtained seven years earlier (in 2011) in the same patients. Material and methods: Urine samples from 34 patients of Wroclaw outpatient HIV Clinic and from 30 HIV-negative individuals with no renal or any other disease were examined. Concentrations of LMWP were measured by immunoenzymatic ELISA tests. Results: Compared to 2011, reduction in the concentration of excreted LMWP was observed. No deleterious renal effect of tenofovir could be shown; however, most patients were receiving the new prodrug (TAF) of reduced nephrotoxicity. Positive correlation between serum creatinine and urine β 2 M was shown and negative correlation between eGFR and urine RBP. Coexistence of HCV infection and the number of T CD4(+) cells also correlated with the concentration of the biomarkers. Conclusions: This retrospective analysis shows a need for long-term renal function monitoring as well as other factors that may influence renal function among HIV patients. RBP, NGAL, and β 2 M have been confirmed to be useful biomarkers for early detection of renal dysfunction.

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“…Następnie TFV w wyniku fosforylacji przekształca się do czynnego difosforanu, który jest inhibitorem odwrotnej transkryptazy. W listopadzie 2015 r. w Europie zarejestrowano nowy lek, który w swoim składzie zawiera nowy prolek tenofowiru -fumaran alafenamidu tenofowiru (TAF) [6,13].…”

Section: Analogi Nukleotydowe (Ntrti)unclassified

“…Ponadto tenofowir znalazł również zastosowanie w leczeniu chorych zakażonych HBV, ponieważ posiada on zdolność hamowania polimerazy DNA wirusa zapalenia wątroby typu B. Mimo iż TDF jest uważany za lek bezpieczny i dobrze tolerowany przez pacjentów, jego przyjmowanie obarczone jest ryzykiem nefrotoksyczności oraz osteopenii i osteoporozy. Może powodować uszkodzenia proksymalnych cewek nerkowych, prowadzących w cięższych przypadkach do rozwoju zespołu Fanconiego [12][13][14].…”

Section: Analogi Nukleotydowe (Ntrti)unclassified

Different risk factors for chronic kidney disease in HIV-infected patients

Marchewka¹,

Domagała²,

Knysz³

et al. 2018

Farm Pol.

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Tom 74 • nr 3 • 2018 new nephrotoxic substances used during chemsex and co-morbidities influencing nephropathy in HIV positive individuals were analysed. Viral pathogens associated with kidney diseases such as CMV, EBV, VZV, adenoviruses and HBV or HCV were presented. Multiplicity and diversity of presented factors indicate how important is the problem of CKD in HIV positive patients. Awareness and analysis of these factors, systematic monitoring of the kidney function allows to adapt and modify therapy carried by clinicians.

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Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea

Abstract: Approximately, 13% of HIV-infected patients treated with TDF had renal dysfunction. Advanced stage of HIV infection was a significant risk factor for renal dysfunction.

Cited by 11 publications

References 18 publications

Determinants of Risk Factors for Renal Impairment among HIV‐Infected Patients Treated with Tenofovir Disoproxil Fumarate‐Based Antiretroviral Regimen in Southern Vietnam

Determinants of Risk Factors for Renal Impairment among HIV‐Infected Patients Treated with Tenofovir Disoproxil Fumarate‐Based Antiretroviral Regimen in Southern Vietnam

Concentration of selected low molecular-weight proteins in urine – a retrospective analysis of chronic kidney disease among HIV patients receiving antiretroviral therapy

Different risk factors for chronic kidney disease in HIV-infected patients

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