Incidence and risk factors for retinopathy of prematurity in North of Iran

Alizadeh, Yousef; Zarkesh, Marjaneh; Moghadam, Reza Soltani; Esfandiarpour, Bahareh; Behboudi, Hassan; Karambin, Mohammad Mehdi; Heidarzade, Abtin

doi:10.4103/2008-322x.176907

Cited by 18 publications

(12 citation statements)

References 29 publications

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“…Being a singleton or a part of multiple gestation was not found to be of significance regarding the development of ROP in our study ( P = 0.75). This was also established in many other studies [9, 23, 28]. However, being a part of multiple gestations and having a sibling –from the same gestation- affected by ROP is associated with increased risk for development of ROP in univariate, but not in the multivariate analysis.…”

Section: Discussionsupporting

confidence: 71%

“…This was a statistically significant difference when compared with the Non-ROP group ( P < 0.0010) even after multivariate analysis. Compared with other countries with similar human development index, the mean gestational age for those who developed ROP –in weeks- was found to be 30.18 ± 2.28 in Iran [23], 30.00 ± 1.67 in Egypt [21], and 28.9 ± 2 in Jordan [20]. In our study, only 6.3% of infants (4 babies) who had a gestational age more than 30 weeks developed ROP.…”

Section: Discussionmentioning

confidence: 99%

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Incidence and risk factors of retinopathy of prematurity in three neonatal intensive care units in Palestine

et al. 2019

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Background Severe Retinopathy of Prematurity (ROP) is a serious vasoproliferative disorder that can affect extremely premature infants. It continues to be one of the most important preventable causes of blindness in children. Our study is aimed at finding the incidence of ROP and its association with some risk factors in Palestine. Methods From the 1st of January 2016 to 31st December 2016, a total number of 115 infants who met the criteria for ROP screening in three neonatal intensive care units were included in the study. The medical records of infants were reviewed retrospectively and multiple factors that may be associated with the development of ROP were collected manually. Results The incidence of ROP and severe type 1 ROP that require treatment was 23.5 and 11.3% respectively. After conducting univariate analysis of risk factors, statistically significant risk factors affecting the development of ROP in our study were: low gestational age, low birth weight, type of multiple gestation, the presence of affected sibling, low level of Hemoglobin at birth, respiratory distress syndrome, low Hemoglobin level, blood transfusion and days on oxygen supplements with either mechanical, non-mechanical methods or both combined. High bilirubin levels were found as a protective factor against the development of ROP. However, when a multivariate analysis was performed, only low gestational age, total days on oxygen supplement and high bilirubin levels were significant regarding the development of ROP. Conclusion The incidence of ROP is considered a relatively low percentage compared to neighboring countries that have higher levels of human development index. Statistically significant risk factors need to be considered when clinicians deal with premature infants.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors of retinopathy of prematurity in three neonatal intensive care units in Palestine

et al. 2019

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“…328 These results have been replicated in multiple subsequent studies, both for the risk of incident ROP and of treatment-requiring ROP. 6,10,11,13,14,17,18,21,47,57,65,75,77,94,102,109,114,122,125,135,138,143,147,152,157,174,202,204,216,228,231,233,236,240,246,255,263,266,271,276,282,283,285,308,311,312,315,335,337,348,362,367,371,373,378,391,398,405,406,410,412,418…”

Section: Major Risk Factorsmentioning

confidence: 99%

“…A number of other infrequently studied factors include inhaled nitric oxide use, 31,212,355,376,378,411 dopamine, 19,133,182,265 phototherapy, 17,23,209,335 sildenafil treatment, 111,128,190,253,323 twin-twin transfusion syndrome, 146 fresh-frozen plasma transfusion, 93 myocardial injury after birth, 236 elevated mean platelet volume, 360,361 and serum neutrophil-to-lymphocyte ratio. 221…”

Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

416

337

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Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management of and research in ROP.

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“…These findings are in agreement with previous reports from Pakistan, Iran, Egypt, and Serbia, which showed a correlation between gestational age and birth weight with ROP. [48495051] The degree of retinal immaturity depends solely on the degree of prematurity, which supports the significant probable link between gestational age and ROP. [5253] Both, extreme prematurity (<28 weeks) and low birth weight (<1000 g) are proposed to have long term effects on visual functions that are believed to be significantly associated with ROP.…”

Section: Discussionmentioning

confidence: 66%

Detection of FZD4, LRP5 and TSPAN12 genes variants in Malay premature babies with retinopathy of prematurity

Khair¹,

Ismail²,

Embong³

et al. 2019

J Ophthalmic Vis Res

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Purpose: To determine the mutational analyses of familial exudative vitreoretinopathy (FEVR)-causing genes in Malay patients with retinopathy of prematurity (ROP) to obtain preliminary data for gene alterations in the Malay community. Methods: A comparative cross-sectional study involving 86 Malay premature babies (ROP = 41 and non-ROP = 45) was performed from September 2012 to December 2014. Mutation analyses in (FEVR)-causing genes ( NDP , FZD4 , LRP5 , and TSPAN12 ) were performed using DNA from premature babies using polymerase chain reaction (PCR) and direct sequencing. Sequencing results were confirmed with PCR-Restriction Fragment Length Polymorphism (RFLP). Results: We found variants of FZD4, LRP5 , and TSPAN12 in this study. One patient from each group showed a non-synonymous alteration in FZD4 , c.502C>T (p.P168S). A synonymous variant of LRP5 [c.3357G>A (p.V1119V)] was found in 30 ROP and 28 non-ROP patients. Two variants of TSPAN12 , c.765G>T (p.P255P) and c.*39C>T (3′UTR), were also recorded (29 and 21 in ROP, 33 and 26 in non-ROP, respectively). Gestational age and birth weight were found to be significantly associated with ROP ( P value < 0.001 and 0.001, respectively). Conclusion: Analysis of data obtained from the ROP Malay population will enhance our understanding of these FEVR-causing gene variants. The c.3357G>A (p.V1119V) variant of LRP5 , and c.765G>T (p.P255P) and c.*39C>T variants of TSPAN12 could be common polymorphisms in the Malay ethnic group; however, this requires further elucidation. Future studies using larger groups and higher numbers of advanced cases are necessary to evaluate the relationship between FEVR-causing gene variants and the risk of ROP susceptibility in Malaysian infants.

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Incidence and risk factors for retinopathy of prematurity in North of Iran

Cited by 18 publications

References 29 publications

Incidence and risk factors of retinopathy of prematurity in three neonatal intensive care units in Palestine

Incidence and risk factors of retinopathy of prematurity in three neonatal intensive care units in Palestine

Retinopathy of prematurity: a review of risk factors and their clinical significance

Detection of FZD4, LRP5 and TSPAN12 genes variants in Malay premature babies with retinopathy of prematurity

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