Incidence and risk factors for hepatocellular carcinoma in 967 patients with cirrhosis

Olmo, Juan A. del; Serra, M.Á.; Rodríguez, F; Escudero, A; Gilabert, S; Rodrigo, J M

doi:10.1007/s004320050215

Cited by 49 publications

(19 citation statements)

References 17 publications

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“…Only two of them (Benvegnu`et al, 1994;Chiaramonte et al, 1998) showed an additive synergism between the two infections, while the others (Zoli et al, 1996;Del Olmo et al, 1998;Benvegnu`et al, 2004;Sangiovanni et al, 2004) showed independence between the two infections in causing HCC.…”

Section: Overt Hepatitis B Virus Infectionmentioning

confidence: 96%

Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence

et al. 2006

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Hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol consumption are major causes of hepatocellular carcinoma (HCC) worldwide. We performed a systematic review of epidemiologic studies carried out on HCC aetiology in Southern Europe, an area with an intermediatehigh prevalence of these agents as well as of putative risk factors such as tobacco smoking, diabetes and obesity. To retrieve the articles, we performed a Medline search for titles and abstracts of articles. After the Medline search, we reviewed the papers and reference lists to identify additional articles. A synergism between HCV infection and HBV infection, overt (hepatitis B virus antigen (HbsAg) positivity) or occult (HBsAg negativity with presence of HBV DNA in liver or serum), is suggested by the results of some studies. The pattern of the risk for HCC due to alcohol intake shows a continuous dose-effect curve without a definite threshold, although most studies found that HCC risk increased only for alcohol consumption above 40-60 g of ethanol per day. Some evidence supports a positive interaction of alcohol intake probably with HCV infection and possibly with HBV infection. A few studies found that coffee has a protective effect on HCC risk due to various risk factors. Some data also support a role of tobacco smoking, diabetes and obesity as single agents or preferably cofactors in causing HCC. In countries with a relatively high alcohol consumption and intermediate levels of HCV and HBV infections (1-3% of population infected by each virus), such as Mediterranean countries, the three main risk factors together account for about 85% of the total HCC cases, leaving little space to other known risk factors, such as haemochromatosis, and to new, still unrecognised, factors as independent causes of HCC.

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Section: Overt Hepatitis B Virus Infectionmentioning

confidence: 96%

Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence

et al. 2006

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“…5,6,8,22,36,64,68,98,[331][332][333] Thirteen studies were excluded. 5,6,8,10,68,284,287,289,293,298,333 Details of the studies are shown in Table 17.…”

Section: Selection Of Parameters: Baseline Characteristics Age At Diamentioning

confidence: 99%

“…in the middle of this range). As there is no reason to suspect that gender imparts a differential risk of mortality in alcohol-related cirrhosis, this figure was used as the base-case point estimate, and the proportion was varied between 50% (an arbitrary value to explore evidence that ALD is becoming more widespread among females 334 ) and 90.2% (as per del Olmo and colleagues' findings 332 ) in sensitivity analyses.…”

Section: Alcoholic Cirrhosismentioning

confidence: 99%

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Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis

Coon¹,

Rogers²,

Hewson³

et al. 2007

Health Technol Assess

151

108

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“…3,14 Predisposing factors associated with HCC, such as viral hepatitis infection, alcohol abuse, metabolic disorders, and other environmental agents, also induce cirrhosis. 15,16 However, it is not clear whether these factors induce HCC directly or whether they act indirectly by producing chronic liver injury and regeneration. Epidemiologic data indicate that patients with chronic hepatitis B (HBV) or C virus (HCV) infection seem to be at an extremely high risk for developing HCC.…”

mentioning

confidence: 99%

Cancer-associated molecular signature in the tissue samples of patients with cirrhosis†

et al. 2004

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Several types of aggressive cancers, including hepatocellular carcinoma (HCC), often arise as a multifocal primary tumor. This suggests a high rate of premalignant changes in noncancerous tissue before the formation of a solitary tumor. Examination of the messenger RNA expression profiles of tissue samples derived from patients with cirrhosis of various etiologies by complementary DNA (cDNA) microarray indicated that they can be grossly separated into two main groups. One group included hepatitis B and C virus infections, hemochromatosis, and Wilson's disease. The other group contained mainly alcoholic liver disease, autoimmune hepatitis, and primary biliary cirrhosis. Analysis of these two groups by the cross-validated leave-one-out machine-learning algorithms revealed a molecular signature containing 556 discriminative genes (P < .001). It is noteworthy that 273 genes in this signature (49%) were also significantly altered in HCC (P < .001). Many genes were previously known to be related to HCC.

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Incidence and risk factors for hepatocellular carcinoma in 967 patients with cirrhosis

Cited by 49 publications

References 17 publications

Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence

Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence

Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis

Cancer-associated molecular signature in the tissue samples of patients with cirrhosis†

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