Incidence and Risk Factors for Incident Hepatitis C Infection Among Men Who Have Sex With Men With HIV-1 Infection in a Large Urban HIV Clinic in Tokyo

Nishijima, Takeshi; Shimbo, Takuro; Komatsu, Hirokazu; Hamada, Yohei; Gatanaga, Hiroyuki; Oka, Shinichi

doi:10.1097/qai.0000000000000044

Cited by 57 publications

(63 citation statements)

References 28 publications

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“…Data from 3014 HIV-infected MSM from 12 cohorts within the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration showed that the HCV incidence increased from 0.55-0.81/100 PY in 1995 to 2.34-5.11/100 PY in 2007 [76]. Similar rises were observed among HIV-infected MSM in North America, Australia, and Asia [63,75,77,79,80]. One phylogenetic analysis revealed a large Europeanwide network of HCV transmission among HIVinfected MSM coinciding with the introduction of combination antiretroviral therapy and associated increases in sexual risk behaviours [82].…”

Section: Incidence Of Hcv Infectionsupporting

confidence: 73%

“…Beginning in 2004, an increase in the incidence of acute HCV infection was reported among HIVinfected MSM in Europe, North America, Australia, and Asia [60,[63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80]11,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. A systematic review of these studies found that the incidence of acute HCV from 2000-2012 was approximately four times higher in HIV-positive MSM (0.61/100 PY) than HIVnegative MSM (0.15/100 PY) [81].…”

Section: Incidence Of Hcv Infectionmentioning

confidence: 99%

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HCV epidemiology in high-risk groups and the risk of reinfection

Midgard

Weir

Palmateer

et al. 2016

Journal of Hepatology

158

100

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Injecting risk behaviours among people who inject drugs (PWID) and high-risk sexual practices among men who have sex with men (MSM) are important routes of hepatitis C virus (HCV) transmission. Current direct-acting antiviral treatment offers unique opportunities for reductions in HCV-related liver disease burden and epidemic control in high-risk groups, but these prospects could be counteracted by HCV reinfection due to on-going risk behaviours after successful treatment. Based on existing data from small and heterogeneous studies of interferon-based treatment, the incidence of reinfection after sustained virological response range from 2-6/100 person years among PWID to 10-15/100 person years among human immunodeficiency virus-infected MSM. These differences mainly reflect heterogeneity in study populations with regards to risk behaviours, but also reflect variations in study designs and applied virological methods. Increasing levels of reinfection are to be expected as we enter the interferon-free treatment era. Individual- and population-level efforts to address and prevent reinfection should therefore be undertaken when providing HCV care for people with on-going risk behaviour. Constructive strategies include acknowledgement, education and counselling, harm reduction optimization, scaled-up treatment including treatment of injecting networks, post-treatment screening, and rapid retreatment of reinfections.

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Section: Incidence Of Hcv Infectionsupporting

confidence: 73%

Section: Incidence Of Hcv Infectionmentioning

confidence: 99%

HCV epidemiology in high-risk groups and the risk of reinfection

Midgard

Weir

Palmateer

et al. 2016

Journal of Hepatology

158

100

View full text Add to dashboard Cite

show abstract

“…Infections in HIV-infected individuals were predominately due to genotype 1a viruses and found only in males possibly reflecting un-reported sex between men. In addition to drug use, the observation of transmission in known HIV positives is not surprising with recent studies from high income countries have demonstrated a high incidence of recent HCV infections in HIV-infected MSMs [8,18,23,[25][26][27][29][30][31][33][34][35][36]. Recent PHE data demonstrated a 21% increase in new HIV infections amongst MSMs in London since 2011 [20].…”

Section: Discussionmentioning

confidence: 93%

Molecular epidemiology of newly acquired hepatitis C infections in England 2008–2011: Genotype, phylogeny and mutation analysis

May

Ngui

Collins

et al. 2015

Journal of Clinical Virology

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“…Among 1182 HIV-positive men, a clinic-based study in Japan reported an HCV incidence of 7.9 and 40.0 per 1000 person-years in non-IDUs and IDUs, respectively. 31 The large-scale Multicenter AIDS Cohort in the US reported an HCV incidence of 1.6 per 1000 person-years in non-IDUs, and this was significantly higher in previous and current IDUs (6.9 and 25.8 per 1000 person-years, respectively). 32 In Melbourne, Australia, 620 HIV-positive men were followed up for a total of 4359 person-years, and the incidence of HCV was significantly higher in IDUs (hazard ratio = 8.7, 95% CI 4.6-16.6).…”

Section: Injecting Drug Use As a Risk Factormentioning

confidence: 99%

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

2017

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Abstract.A systematic review was performed on the evidence of sexual transmission of hepatitis C virus (HCV) in gay and bisexual men (GBM). Studies conducted in industrialised countries and published in English from 2000 to 2015 with data on HCV in GBM were included. Pooled estimates of prevalence and incidence of HCV infection were stratified by study settings and participants' HIV status using random effect models. Case-series reports were summarised descriptively. Of the 38 cross-sectional studies, the pooled HCV prevalence was substantially higher in HIV-positive men (8.3%, 95% CI: 6.7-9.9) than in HIV-negative men (1.5%, 95% CI 0.8-2.1), and higher in those who reported injecting drug use (34.8%, 95% CI 26.9-42.7) than in those who did not (3.5%, 95% CI 2.4-4.5). Of the 16 longitudinal studies, the pooled HCV incidence was markedly higher in clinic-based (7.0 per 1000 person-years, 95% CI 4.6-9.5) than in community-based (1.4 per 1000 person-years, 95% CI 0.7-2.1) studies, and in HIV-positive men (6.4 per 1000 person-years, 95% CI 4.6-8.1) than in HIV-negative men (0.4 per 1000 person-years, 95% CI 0-0.9). Since the early 2000s, 15 case-series reports increasingly pointed to the importance of sexual transmission of HCV in mainly HIV-positive men. Injecting drug use remained the major transmission route of HCV in GBM. Receptive condomless intercourse and concurrent ulcerative sexually transmissible infections are likely drivers that facilitated HCV sexual transmission in HIV-positive men. HCV incidence remains very low in HIV-negative GBM.

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Incidence and Risk Factors for Incident Hepatitis C Infection Among Men Who Have Sex With Men With HIV-1 Infection in a Large Urban HIV Clinic in Tokyo

Abstract: Incident HCV infection is increasing among HIV-1-infected MSM noninjection drug users at resource-rich setting in Asia. Illicit drug use is an independent risk factor for incident HCV infection in this population.

Cited by 57 publications

References 28 publications

HCV epidemiology in high-risk groups and the risk of reinfection

HCV epidemiology in high-risk groups and the risk of reinfection

Molecular epidemiology of newly acquired hepatitis C infections in England 2008–2011: Genotype, phylogeny and mutation analysis

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

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