Incidence and risk factors of lymphedema after breast cancer treatment: 10 years of follow-up

Pereira, Ana Carolina Padula Ribeiro; Koifman, Rosalina Jorge; Bergmann, Anke

doi:10.1016/j.breast.2017.09.006

Cited by 186 publications

(123 citation statements)

References 32 publications

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“…3 During the past 10 years, many efforts have been made in breast cancer diagnosis and therapy, including combinations of surgery, hormone therapy, and adjuvant therapy. 4 However, the overall prognosis of breast cancer is still unsatisfactory due to recurrence and distant metastasis. 5 The proliferation and metastasis of breast cancer is a multi-step biological process that involves the activation or silencing of genes and epigenetic modifications; however, the details of its molecular mechanism are still largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Long Intergenic Non-Coding RNA 01121 Promotes Breast Cancer Cell Proliferation, Migration, and Invasion via the miR-150-5p/HMGA2 Axis

Wang

Cao

et al. 2019

CMAR

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Purpose: Long intergenic noncoding RNA 01121 (LINC01121) has been reported to be aberrantly expressed and acts as an oncogene in pancreatic cancer. However, the detailed molecular mechanism of LINC01121 in breast cancer remains largely unclear. In this study, we aimed to investigate the expression and biological function of LINC01121 in breast cancer. Methods: LINC01121 and miR-150-5p expression were measured in breast cancer cell lines using quantitative reverse transcription PCR. MTS and flow cytometry assays were performed to determine cell proliferation, the cell cycle, and apoptosis. Cell migration and invasion were assessed by transwell assay. The protein expression of HMGA2 in breast cancer cell lines was measured by Western blotting. A luciferase reporter assay was used to assess the binding of LINC01121 and miR-150-5p. Results: We found that LINC01121 was markedly up-regulated in breast cancer cell lines compared with normal breast epithelial cells. LINC01121 down-regulation markedly suppressed cell proliferation, cell cycle progression, migration, and invasion and promoted apoptosis in breast cancer cells. Further investigation showed that LINC01121 could serve as a molecular sponge for miR-150-5p and indirectly modulate the expression of its target, HMGA2. Moreover, miR-150-5p knockdown rescued the effects of LINC01121 down-regulation on HMGA2 protein expression, cell proliferation, cell cycle progression, apoptosis, migration, and invasion in breast cancer cells. Conclusion: Knockdown LINC01121 inhibited breast cancer cell proliferation, migration, and invasion via the miR-150-5p/HMGA2 axis.

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Section: Introductionmentioning

confidence: 99%

Long Intergenic Non-Coding RNA 01121 Promotes Breast Cancer Cell Proliferation, Migration, and Invasion via the miR-150-5p/HMGA2 Axis

Wang

Cao

et al. 2019

CMAR

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“…Further, lymphedema incidence rates can vary with the length of the follow‐up period and the methods of determining edema. For example, in a retrospective study by Pereira et al 964 women having mastectomy and adjuvant RT had arms measured by circumference and estimation of lymphedema using Frustrum calculation. The incidence of lymphedema was 13.5% at 2‐years, 30.2% at 5‐years, and 41.1% at 10‐years.…”

Section: Discussionmentioning

confidence: 99%

Late locoregional complications associated with adjuvant radiotherapy in the treatment of breast cancer: Systematic review and meta‐analysis

Kanda

Vieira

Lima

et al. 2019

Journal of Surgical Oncology

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This systematic review with meta‐analysis addressed late locoregional complications associated with adjuvant radiotherapy (RT) in breast cancer. Among 2120 titles, ten comparative studies in patients undergoing surgery vs surgery and radiotherapy reporting complications were evaluated. RT was associated with an increased risk of capsular contracture and decreased the mobility of the upper limb. A borderline association of lymphedema risk using RT was noted in the random‐effects model but was significant in the fixed‐effects model.

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“…Lymphedema has various definitions as well, with a prevalence up to 94% depending on characteristics and definition used, the timing of diagnosis, and study design . Significant risk factors for developing lymphedema are high BMI, mastectomy, number of lymph nodes removed, and axillary lymph node dissection . Lymphedema can lead to significant difficulty with normal activities.…”

Section: Long‐term Sequelaementioning

confidence: 99%

Long‐Term Effects of Breast Cancer Surgery, Treatment, and Survivor Care

Lovelace

McDaniel

Golden

2019

J Midwife Womens Health

265

182

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Women are increasingly surviving breast cancer, but up to 90% experience unexpected long‐term sequelae as a result of treatment. Symptoms may include physical, functional, emotional, and psychosocial changes that can dramatically alter the quality of life for breast cancer survivors. Primary care clinicians, including midwives, are likely to care for these women and should be familiar with common symptoms, treatment, and best practices to avoid permanent dysfunction. A holistic approach to assessment, treatment, and referral as needed is the most effective strategy. Although women experience significant changes after breast cancer treatment, many fail to receive thorough assessment of their symptoms, education about interventions, and treatment options to optimize health promoting strategies. Disparities exist in treatment availability, options, and survivorship. Long‐term physical changes include anatomic changes, chronic pain, phantom breast pain, axillary web syndrome, and lymphedema. In addition, women may have decreased strength, aerobic capacity, mobility, fatigue, and cognitive dysfunction. Emotional and psychosocial changes include depression, anxiety, fatigue, concerns about body image, and issues with sexuality. Treatment should be multifactorial based on thorough assessment of symptoms and can include medication, exercise, counseling, physical and occupational therapy, and alternative and complementary therapies. Primary care and gynecologic clinicians are well positioned to provide thorough evaluation, education, treatment, and referral for the most common sequelae of mastectomy and breast cancer treatments.

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Incidence and risk factors of lymphedema after breast cancer treatment: 10 years of follow-up

Cited by 186 publications

References 32 publications

<p>Long Intergenic Non-Coding RNA 01121 Promotes Breast Cancer Cell Proliferation, Migration, and Invasion via the <em>miR-150-5p</em>/HMGA2 Axis</p>

<p>Long Intergenic Non-Coding RNA 01121 Promotes Breast Cancer Cell Proliferation, Migration, and Invasion via the <em>miR-150-5p</em>/HMGA2 Axis</p>

Late locoregional complications associated with adjuvant radiotherapy in the treatment of breast cancer: Systematic review and meta‐analysis

Long‐Term Effects of Breast Cancer Surgery, Treatment, and Survivor Care

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