Incidence and Risk Factors of Retinopathy of Prematurity in Mashhad, Northeast Iran

Yadav

J. Kathmandu Med. Coll.

et al. 2017

Background: Retinopathy of prematurity is a vascular retinal disease that can cause blindness in premature new born babies. Several risk factors are associated with the incidence of ROP. Information and data on risk factors associated with ROP in context to Nepalese population is scarcely documented in literature. Objectives: The purpose of this study was to evaluate the risk factors of retinopathy of prematurity in premature infants admitted in the neonatal intensive care unit of Tribhuvan University Teaching Hospital. Methods: Neonates with gestational age of 36 weeks or less and birth weight of 2000 gram or less admitted to neonatal intensive care unit (NICU), during 2013 to 2015 were screened for retinopathy of prematurity. Risk factors and severity of retinopathy of prematurity were evaluated. The initial examination was carried out at 4-6 weeks after birth by indirect ophthalmoscope and retinopathy of prematurity positive and negative infants were compared subsequently. The Chisquare and independent t-tests were used for statistical analysis. A p value less than 0.05 was considered statistically signifi cant. Results: The incidence of retinopathy of prematurity was 22.6% and severe retinopathy of prematurity requiring treatment was observed in 3.2% of 93 neonates who had eye examinations. There was a signifi cant relationship between the occurrence of ROP and birth weight (p=0.000), gestational age (p=0.000), duration of oxygen therapy (p=0.009) and sepsis (p=0.002). However, insignifi cant relationship was observed between the occurrence of retinopathy of prematurity and gender, type of delivery, multiple gestation, premature rupture of foetal membrane, respiratory distress syndrome and hyperbilirubinaemia. Conclusion: The risk factors contributing to development of retinopathy of prematurity showed signifi cant relationship with immaturity, duration of oxygen supplementation and septicaemia.

Section: Discussionsupporting

confidence: 51%

Risk factors associated with retinopathy of prematurity among neonates in a tertiary care hospital in Nepal

Yadav

J. Kathmandu Med. Coll.

et al. 2017

Int. J. Curr. Res. Med. Sci.

“…In our study, the mechanical ventilation and CPAP were non-significant risk factors for ROP and this was in agreement with Hakeem et al 19 , Abrishami et al 27 .. However, Shah et al 24 in their study observed significant association between mechanical ventilation, CPAP and ROP.…”

Section: Discussionsupporting

confidence: 92%

Incidence and Risk Factors of Retinopathy of Prematurity (ROP) in Neonates of Weight 1.5 to 2 kg

2017

Objective :-To find incidence and risk factors of ROP in neonates of birth weight 1.5-2 kg. Methods: -All the neonates admitted in NICU at GMC, Amritsar from August 2014 to July 2015 with birth weight 1.5-2 kg were enrolled and followed up for all neonatal problems and interventions and screened for ROP by indirect ophthalmoscope at 4 weeks of postnatal age and followed up till retinal vascularization was complete. Neonatal risk factors including diseases and various interventions and treatment given to them were noted and data was analyzed statistically. Results: -A total of 70 children were screened for ROP, 12 of them were diagnosed with retinopathy of prematurity. Thus, incidence of ROP was 17.1%. 11 of them had stage 1 ROP, 1 had stage 2 ROP with plus disease. On univariate analysis, sepsis and oxygen duration of more than 7 days were significantly associated with development of ROP. None of the risk factor was independent predictor of ROP on logistic regression analysis. Conclusion: -Neonates with birth weight upto 2 kg having sepsis and oxygen therapy duration of more than 7 days and having other risk factors should be screened for ROP as they can develop ROP including threshold ROP.

Clinical Epidemiology and Global Health

“…Apnea and oxygen therapy were associated with development of ROP in the study by Chaudhari et al 9 High flow oxygen therapy by CPAP was associated with the development of ROP similar to studies by Shah et al 14 The duration of oxygen therapy for development of ROP was significant as an independent variable in accordance to Karna et al 18 Similar to our study Gupta et al 19 states that oxygen, sepsis and apnea were significant as independent risk factors. Majid Abrishami et al 20 states that low Apgar score is significantly associated with development of ROP. In our study low Apgar had a significant role in development of ROP but on regression analysis it was not found significant as an independent factor.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of retinopathy of prematurity in a tertiary care hospital in South India

Sathar

Shanavas

Girijadevi

et al. 2018