Incidence and risk factors of major opportunistic infections after initiation of antiretroviral therapy among advanced HIV-infected patients in a resource-limited setting

Manosuthi, Weerawat; Chaovavanich, Achara; Tansuphaswadikul, Somsit; Prasithsirikul, Wisit; Inthong, Y.; Chottanapund, Suthat; Sittibusaya, Chayanan; Moolasart, Visal; Termvises, Patamavadee; Sungkanuparph, Somnuek

doi:10.1016/j.jinf.2007.07.002

Cited by 62 publications

(68 citation statements)

References 23 publications

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“…Similar finding were also observed in a study conducted in Nigeria showing that advanced WHO clinical stage at baseline to be an independent clinical risk factors for the occurrence of OIs [17]. Similar findings were also observed in studies [15,[20][21][22][23]. This could be because of lower immunity as WHO staging is higher that further predispose for OIs.…”

Section: Discussionsupporting

confidence: 88%

“…The study found that 141 (33.3%) of HIV patients taking ART had got at least one OI during the study period and overall OIs prevalence of 42.8% with repeated infection. When compared with other similar studies, the prevalence of OIs in the current study area is comparable with a study conducted by Manosuthi et al in a resource limited setting with a prevalence of 30% [15]. A study conducted in Taiwan showed that the prevalence of OIs to be 47.6%, which is greater than the current study area [16].…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

Prevalence of Opportunistic Infections and Associated Factors among HIV Positive Patients taking Anti-Retroviral Therapy in DebreMarkos Referral Hospital, Northwest Ethiopia

Moges¹

2014

J AIDS Clin Res

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 84%

Prevalence of Opportunistic Infections and Associated Factors among HIV Positive Patients taking Anti-Retroviral Therapy in DebreMarkos Referral Hospital, Northwest Ethiopia

Moges¹

2014

J AIDS Clin Res

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“…Due to adverse reactions like giddiness and failure to adhere dosage regimen, and due to IRIS most of the subjects are diagnosed with opportunistic infections even after the initiation of treatment in the present study. Weerawat Manosuthi et.al, 12 found that mean duration to get first opportunistic infection was less than 3 months as similar to our study.…”

supporting

confidence: 91%

Epidemiological Study of Opportunistic Infections in HIV Sero Positive Patients in South India

Harikrishna¹

2017

jmscr

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“…It is similar to the 8% of patients found during the first year after initiating HAART in a resource-poor setting in Thailand. 7 We could not determine how many patients remained at home with IRIS or may have died of IRIS outside the hospital. These statistics were not obtainable because more than half the patients (50%) with IRIS were lost to follow-up.…”

Section: Discussionmentioning

confidence: 99%

Immune Reconstitution Inflammatory Syndrome in a Resource-Poor Setting

Klotz

Mohammed

Woldemichael

et al. 2009

Journal of the International Association of Physicians in AIDS

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The immune reconstitution inflammatory syndrome (IRIS) associated with highly active antiretroviral therapy (HAART) was studied in rural Ethiopian HIV-infected patients. Review of 1002 charts in an outpatient clinic was conducted. The median CD4 count was 89 cells/mm3. Ninety-eight patients were hospitalized after initiation of HAART, of whom 74 were hospitalized for manifestations of IRIS (ie, 7% of patients on HAART). Of the 74 patients hospitalized with IRIS, 27 patients had tuberculosis; 12 patients, cryptococcal meningitis; 7 patients, toxoplasmosis; 6 patients, pneumonia and/or effusion; and 5 patients, Pneumocystis jiroveci pneumonia (PCP). Ten adult patients were admitted with gastroenteritis, heretofore not recognized as a manifestation of IRIS. Eighty-one percent of IRIS patients were hospitalized within 3 months of beginning HAART and 99% by 6 months. Of those hospitalized with IRIS, 4 patients (5%) died while in the hospital (3 with cryptococcal meningitis). Thirty-seven or 50% of those hospitalized with IRIS were lost to medical follow up, thus the mortality rate is likely a gross underestimate of the severity of IRIS. In resource-poor settings where the primary goal is to initiate HAART, IRIS may go unrecognized and have fatal consequences.

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Incidence and risk factors of major opportunistic infections after initiation of antiretroviral therapy among advanced HIV-infected patients in a resource-limited setting

Cited by 62 publications

References 23 publications

Prevalence of Opportunistic Infections and Associated Factors among HIV Positive Patients taking Anti-Retroviral Therapy in DebreMarkos Referral Hospital, Northwest Ethiopia

Prevalence of Opportunistic Infections and Associated Factors among HIV Positive Patients taking Anti-Retroviral Therapy in DebreMarkos Referral Hospital, Northwest Ethiopia

Epidemiological Study of Opportunistic Infections in HIV Sero Positive Patients in South India

Immune Reconstitution Inflammatory Syndrome in a Resource-Poor Setting

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