Incidence and Risk Factors of Surgical Site Infection After Cranial Surgery for Patients with Brain Tumors: A Systematic Review and Meta-analysis

Lee, Keng Siang; Borbas, Balint; Plaha, Puneet; Ashkan, Keyoumars; Jenkinson, Michael D.; Price, Stephen J.

doi:10.1016/j.wneu.2024.02.133

Cited by 3 publications

(1 citation statement)

References 50 publications

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“…A systematic review and meta-analysis showed that the incidence of surgical site infections after craniotomy following surgery for posterior fossa tumors was 9.67%. 18 The following properties of the posterior fossa surgery are associated with the high risk of CNS infection.…”

Section: Infratentorial (Posterior Fossa) Surgerymentioning

confidence: 99%

Risk Factors for Central Nervous System Infections After Craniotomy

Liu,

et al. 2024

JMDH

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The central nervous system (CNS) is less prone to infection owing to protection from the brain-blood barrier. However, craniotomy destroys this protection and increases the risk of infection in the brain of patients who have undergone craniotomy. CNS infection after craniotomy significantly increases the patient’s mortality rate and disability. Controlling the occurrence of intracranial infection is very important for post-craniotomy patients. CNS infection after craniotomy is caused by several factors such as preoperative, intraoperative, and post-operative factors. Craniotomy may lead to postsurgical intracranial infection, which is mainly associated with surgery duration, infratentorial (posterior fossa) surgery, cerebrospinal fluid leakage, drainage tube placement, unregulated use of antibiotics, glucocorticoid use, age, diabetes, and other systemic infections. Understanding the risk factors of CNS infection after craniotomy can benefit reducing the incidence of intracranial infectious diseases. This will also provide the necessary guidance and evidence in clinical practice for planning to control intracranial infection in patients with craniotomy.

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Section: Infratentorial (Posterior Fossa) Surgerymentioning

confidence: 99%

Risk Factors for Central Nervous System Infections After Craniotomy

Liu,

et al. 2024

JMDH

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3D-printed implants loaded with acriflavine for glioblastoma treatment

Korelidou,

Domínguez-Robles,

Islam

et al. 2024

International Journal of Pharmaceutics

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Carbapenem-resistant Klebsiella oxytoca transmission linked to preoperative shaving in emergency neurosurgery, tracked by rapid detection via chromogenic medium and whole genome sequencing

Jiang,

Lyu,

Liu

et al. 2024

Front. Cell. Infect. Microbiol.

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ObjectivesThis study describes the detection and tracking of emergency neurosurgical cross-transmission infections with carbapenem-resistant Klebsiella oxytoca (CRKO).MethodsWe conducted an epidemiological investigation and a rapid screening of 66 surveillance samples using the chromogenic selective medium. Two CRKO isolates from infected patients and three from the preoperative shaving razors had similar resistance profiles identified by the clinical laboratory.ResultsThe whole genome sequencing (WGS) results identified all isolates as Klebsiella michiganensis (a species in the K. oxytoca complex) with sequence type 29 (ST29) and carrying resistance genes blaKPC-2 and blaOXY-5, as well as IncF plasmids. The pairwise average nucleotide identity values of 5 isolates ranged from 99.993% to 99.999%. Moreover, these isolates displayed a maximum genetic difference of 3 among 5,229 targets in the core genome multilocus sequence typing scheme, and the razors were confirmed as the contamination source. After the implementation of controls and standardized shaving procedures, no new CRKO infections occurred.ConclusionContaminated razors can be sources of neurosurgical site infections with CRKO, and standard shaving procedures need to be established. Chromogenic selective medium can help rapidly identify targeted pathogens, and WGS technologies are effective mean in tracking the transmission source in an epidemic or outbreak investigation. Our findings increase the understanding of microbial transmission in surgery to improve patient care quality.

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Incidence and Risk Factors of Surgical Site Infection After Cranial Surgery for Patients with Brain Tumors: A Systematic Review and Meta-analysis

Cited by 3 publications

References 50 publications

Risk Factors for Central Nervous System Infections After Craniotomy

Risk Factors for Central Nervous System Infections After Craniotomy

3D-printed implants loaded with acriflavine for glioblastoma treatment

Carbapenem-resistant Klebsiella oxytoca transmission linked to preoperative shaving in emergency neurosurgery, tracked by rapid detection via chromogenic medium and whole genome sequencing

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