Incidence and risk factors of diabetes mellitus in the Chinese population: a dynamic cohort study

Long-yi, Xue; Wang, Huiying; He, Yunzhen; Sui, Mengyun; Li, Wanqing; Lin, Minggui; Xiao, Ying

doi:10.1136/bmjopen-2021-060730

Cited by 6 publications

(3 citation statements)

References 37 publications

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“… 60 Xue et al found that alcohol consumption is associated with an increased risk of DM. 53 This study showed no clear correlation between the incidence of DM and smoking or alcohol consumption in HTN patients. 60 In this study, there was no significant relationship between smoking and alcohol consumption and the risk of DM in HTN patients, which may be related to the differences in research methods, study sample size, and indicators included in the analysis of different studies, which need to be confirmed by further research.…”

Section: Discussioncontrasting

confidence: 55%

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Association Between ALDH2 Polymorphisms and the Risk of Diabetes Mellitus in Hypertensive Patients

Zeng,

Liu,

Xie

2023

IJGM

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Background Aldehyde dehydrogenase 2 ( ALDH2 ) polymorphisms have been extensively studied in patients with hypertension (HTN) and diabetes mellitus (DM) in recent years. However, it is unclear whether ALDH2 polymorphisms are correlated with the risk of developing DM in patients with HTN. This study was designed to examine the association between ALDH2 single nucleotide polymorphism (SNP) rs671 and the risks of DM in patients with HTN. Methods This study retrospectively analyzed the patients with HTN who were treated in Meizhou People’s Hospital from August 2016 to December 2020, 788 HTN patients with DM as case patients, and 1632 HTN patients without DM history as controls. ALDH2 polymorphisms were analyzed using a polymerase chain reaction (PCR)-gene chip. Differences in ALDH2 genotypes between subjects and controls were compared. To analyze the relationship between ALDH2 genotype and DM risk, multiple logistic regression analysis was performed after adjusting for gender, age, smoking history, and drinking history. Results The proportion of the G/A plus A/A genotype was significantly higher in patients with DM than in controls (52.8% vs 48.2%, P =0.033). DM patients with G/A genotype had lower LDL-C ( P <0.017) than those with G/G genotype. The results of logistic regression analysis indicated that the G/A genotype increased the risk of DM in HTN patients, with an adjusted odds ratio (OR) of 1.209 (95% confidence interval (CI) 1.010–1.446) ( P =0.038), whereas the G/A plus A/A genotype in the dominant model increased the risk of DM significantly, with an adjusted OR of 1.203 (95% CI 1.013–1.428) ( P =0.035). Conclusion ALDH2 A allele (G/A + A/A genotype) increased the risk of DM in patients with HTN.

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Section: Discussioncontrasting

confidence: 55%

“… 51 , 52 Xue et al found that age is associated with an increased risk of DM. 53 However, study has reported inconsistent results. 54 This study showed that the incidence of DM in different age groups was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Association Between ALDH2 Polymorphisms and the Risk of Diabetes Mellitus in Hypertensive Patients

Zeng,

Liu,

Xie

2023

IJGM

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“…The incidence of diabetes is growing every year. The occurrence rate of T2DM in China was at 12.4% in 2018, and its complications have become a significant burden on the health of Chinese people (Xue et al, 2022). Patients diagnosed type 1 diabetes mellitus (T1DM) need to inject insulin daily to control their blood glucose.…”

Section: Introductionmentioning

confidence: 99%

Application and challenge of pancreatic organoids in therapeutic research

Chen,

Lu,

Wang

et al. 2024

Front. Pharmacol.

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The in-vivo non-human primate animal and in-vitro cell disease models play a crucial part in the study of the mechanisms underlying the occurrence and development of pancreatic diseases, but with increasingly prominent limitations with in-depth research. Organoids derived from human pluripotent and adult stem cells resemble human in-vivo organs in their cellular composition, spatial tissue structure and physiological function, making them as an advantageous research tool. Up until now, numerous human organoids, including pancreas, have been effectively developed, demonstrating significant potential for research in organ development, disease modeling, drug screening, and regenerative medicine. However, different from intestine, liver and other organs, the pancreas is the only special organ in the human body, consisting of an exocrine gland and an endocrine gland. Thus, the development of pancreatic organoid technology faces greater challenges, and how to construct a composite pancreatic organoid with exocrine and endocrine gland is still difficult in current research. By reviewing the fundamental architecture and physiological role of the human pancreas, along with the swiftly developing domain of pancreatic organoids, we summarize the method and characteristics of human pancreatic organoids, and its application in modeling pancreatic diseases, as a platform for individualized drug screening and in regenerative medicine study. As the first comprehensive review that focus on the pharmacological study of human pancreatic organoid, the review hopes to help scholars to have a deeper understanding in the study of pancreatic organoid.

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