Incidence and Risk Factors of Glucocorticoid-Induced Diabetes Mellitus in Lymphoma Patients Treated with Glucocorticoid-Containing Chemotherapy

Abstract

A 3 4 7 -A 7 6 6 combinations compared to other endocrine therapies. We compared progressionfree survival (PFS) hazard ratio (HR) of palbociclib combinations against first-and second-line endocrine therapies using a mixed-treatment comparison (MTC) metaanalysis of randomized, controlled trials (RCTs). Methods: A systematic literature review conducted by two independent reviewers identified relevant RCTs in ABC/ MBC. Separate networks were developed for palbociclib plus letrozole and palbociclib plus fulvestrant. MTC analyses were conducted using a Bayesian approach. Based on output from MTC, treatment rankings were established using the surface under the cumulative ranking curve (SUCRA). Results: Sixty-four unique studies met inclusion criteria. Because of sparse networks, fixed-effects model results are reported. Palbociclib plus letrozole had the highest SUCRA value (99.9%) and was associated with significantly longer PFS than all first-line comparators, with the following posterior median PFS HRs and 95% credible intervals (CrI): anastrozole 1 mg, 0.58 (0.42-0.83); and tamoxifen 20 or 40 mg, 0.41 (0.31-0.53). Palbociclib plus fulvestrant had the second highest SUCRA value (93.9%) and was associated with significantly longer PFS than the second-line comparators: anastrozole 1 mg, 0.37 (0.27-0.50); letrozole 2.5 mg, 0.36 (0.22-0.60); fulvestrant 250 mg, 0.36 (0.27-0.48); fulvestrant 500/250 mg, 0.41 (0.23-0.68); and exemestane 25 mg, 0.39 (0.23-0.64). There was no significant difference in the PFS HR for palbociclib plus fulvestrant compared to everolimus plus exemestane (1.03; 95%, 0.58-1.76). ConClusions: The MTC results suggest that palbociclib plus letrozole and palbociclib plus fulvestrant are associated with significantly improved PFS compared with all first-line and most second-line endocrine treatments for ABC/MBC. PCN14