Incidence and Risk Factors Related to Symptomatic Venous Thromboembolic Events After Esophagectomy for Cancer

Mantziari, Styliani; Gronnier, Caroline; Gagnière, Johan; Thereaux, Jéremie; Demartines, Nicolas; Schäfer, Markus; Mariette, C.; Dhahri, Abdennahceur; Lignier, Delphine; Cossé, Cyril; Régimbeau, Jean-Marc; Luc, G.; Collet, Denis; Cabau, Magalie; Jougon, Jacques; Badic, Bogdan; Lozac’h, P.; Bail, Jean Pierre; Cappeliez, Serge; Nakadi, Issam El; Lebreton, Gil; Alvès, Arnaud; Flamein, Renaud; Pezet, Denis; Pipitone, Federica; Stan-Iuga, Bogdan; Coueffe, Xaviera; Contival, Nicolas; Pappalardo, Eric; Msika, Simon; Hec, Flora; Vanderbeken, Marguerite; Tessier, Williams; Briez, Nicolas; Fredon, Fabien; Gainant, A; Mathonnet, Muriel; Bigourdan, Jean-Marc; Mezoughi, Salim; Ducerf, C.; Baulieux, J.; Mabrut, Jean‐Yves; Pasquer, Arnaud; Baraket, Oussama; Poncet, Gilles; Adam, M.; Vaudoyer, Delphine; Enfer, Peggy Jourdan; Villeneuve, Laurent; Gléhen, Olivier; Coste, Thibault; Fabre, Jean‐Michel; Marchal, Frédéric; Frisoni, Romain; Ayav, Ahmet; Brunaud, Laurent; Bresler, L.; Cohen, Charlotte; Aze, Olivier; Vénissac, Nicolas; Pop, Dániel; Mouroux, Jérôme; Donici, Ion; Prudhomme, Michel; Felli, Emanuele; Lisunfui, Stéphanie; Seman, Marie; Petit, Gaëlle; Karoui, Mehdi; Trésallet, Christophe; Ménégaux, Fabrice; Vaillant, Jean‐Christophe; Hannoun, L.; Malgras, Brice; Lantuas, Denis; Pautrat, Karine; Pocard, Marc; Valleur, Patrice; Lefèvre, Jérémie H.; Chafaı̈, Najim; Balladur, Pierre; Lefrançois, Magalie; Parc, Yann; Paye, François; Tiret, Emmanuel; Nedelcu, Marius; Laface, Letizia; Perniceni, Thierry; Gayet, Brice; Turner, Kathleen; Meunier, Bernard; Filipello, Alexandre; Porcheron, Jack; Tiffet, Olivier; Kamlet, Noémie; Chemaly, Rodrigue; Klipfel, Amandine; Pessaux, Patrick; Brigand, Cécile; Rohr, S.; Rieu, M. Chalret du; Carrère, Nicolas; Re, Chiara; Dumont, Frédéric; Goèré, Diane; Elias, D. J.; Bertrand, Claude

doi:10.1016/j.athoracsur.2016.03.093

Cited by 24 publications

(17 citation statements)

References 28 publications

(50 reference statements)

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“…In general, the overall 3.5% incidence of DVT/PE in our study was similar to the 2.9% (84 of 2,944) that noted in a large multicenter study that examined the incidence of postoperative symptomatic venous thromboembolic disease [23]. Interestingly, those investigators also found that a higher ASA class (III or IV), postoperative pneumonia, and acute respiratory distress syndrome were significantly associated with an increased risk of DVT/PE in a multivariate analysis [23]. Although we did not specifically evaluate for respiratory complications, our data did not show a significant relationship between a higher ASA class (III or IV) and DVT/PE.…”

Section: Commentsupporting

confidence: 88%

“…The time frame of 30 days to observe thrombotic complications was chosen arbitrarily. There is no established consensus in the surgical literature for postoperative thrombosis, and studies have reported thrombotic complications from 1 up to 90 days after the operation [23,[28][29][30]. Some patients may have had small, asymptomatic pleural effusions after the operation, some of which may have been chylous.…”

Section: Commentmentioning

confidence: 99%

“…Further, we did not have data on the presence of anastomotic leaks, volume of chest tube output, or postoperative pneumonia, which could have provided an added understanding of how these parameters interact with the risk for thrombosis, but we attempted to focus on factors that have a more direct influence on the development of chylothorax or vascular thrombosis. Data on preoperative radiotherapy were not analyzed because a large multicenter study demonstrated no significant correlation between preoperative radiotherapy and DVT/PE [23].…”

Section: Commentmentioning

confidence: 99%

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Chylothorax as a Risk Factor for Thrombosis in Adults: A Proof-of-Concept Study

Hoskote

Yadav

Jagtap

et al. 2018

The Annals of Thoracic Surgery

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Section: Commentsupporting

confidence: 88%

Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

Chylothorax as a Risk Factor for Thrombosis in Adults: A Proof-of-Concept Study

Hoskote

Yadav

Jagtap

et al. 2018

The Annals of Thoracic Surgery

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“…Although the methods of diagnosis and treatment of PAPE have been continuously developed in recent years, including imaging diagnosis, interventional surgery and medicinal chemotherapy, the overall survival rate of patients with PAPE is extremely low. It was reported that the short-term mortality of patients with PAPE was between 10% and 23.1% [5][6][7][8][9]. Therefore, identifying the preoperative risk factors associated with mortality may help to direct more aggressive treatment strategies, such as brinolytic therapy, towards patients who will derive the greatest bene t.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of the preoperative neutrophil-to-lymphocyte ratio and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism

Liu

Zhan

Huang

et al. 2020

Preprint

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Background: This retrospective study aimed to investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism (PAPE).Methods: We retrospectively reviewed the medical records of 101 patients with PAPE admitted from September 1, 2012, to March 31, 2019. The characteristics, surgical information, admission examination data and mortality within 30 days after PAPE were obtained from our electronic medical recording system and follow-up. The associations between the NLR, PLR, and other predictors and 30-day mortality were analyzed with univariate and multivariate analyses. Then, the nomogram including the independent predictors was established and evaluated.Results: Twenty-four patients died within 30 days, corresponding to a 30-day mortality rate of 23.8%. The results of the multivariate analysis indicated that both the NLR and albumin were independent predictors for 30-day mortality in patients with PAPE. The probability of death increased by approximately 17.1% (OR=1.171, 95% CI: 1.073–1.277, P=0.000) with a one-unit increase in the NLR, and the probability of death decreased by approximately 15.4% (OR=0.846, 95% CI: 0.762c–0.939, P=0.002) with a one-unit increase in albumin. The area under the curve of the nomogram was 0.888 (95% CI: 0.812-0.964).Conclusion: Our findings showed that an elevated NLR and decreased albumin were related to poor prognosis in patients with PAPE. The NLR and albumin were independent prognostic factors for PAPE.

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“…Although the way of diagnosis and treatment of PAPE have been continuously developed in recent years, including imaging diagnosis, interventional surgery and medicinal chemotherapy, the overall survival rate of patients with PAPE was extremely low. It was reported that the short-term mortality of patients with PAPE was between 10% and 23.1% [5][6][7][8][9]. Therefore, identifying the preoperative risk factors associated with mortality may help to direct more aggressive treatment strategies towards patients who will derive the greatest benefit.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of preoperative neutrophil-to-lymphocyte ratio and albumin for 30-days mortality in patients with postoperative acute pulmonary embolism

Liu

Zhan

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background This retrospective study aimed to investigate the prognostic value of neutrophil–lymphocyte ratio (NLR) and albumin in 30-days mortality in patients with postoperative acute pulmonary embolism (PAPE).Methods We retrospectively reviewed the medical records of 101 patients with PAPE admitted from September 1, 2012 to March 31, 2019. The characteristics, surgical information, admission examination data and mortality within 30-days after PAPE were obtained from our electronic medical recording system and follow up. The association between NLR, PLR, and other predictors and 30-days mortality were analyzed with univariate and multivariate analyses. Then, the nomogram include the independent predictors was established and evaluated.Results 24 patients died within 30 days corresponding to 30-days mortality of 23.8%. The results of the multivariate analysis indicated that both NLR and albumin are independent predictors for 30-days mortality in patients with PAPE. The probability of death increased about 17.1% (OR=1.171, 95% CI: 1.073–1.277, P=0.000) with one unit of increase of NLR, and the probability of death decreased about 15.4% (OR=0.846, 95% CI: 0.762c–0.939, P=0.002) with one unit of increase of albumin. The area under the curve of nomogram was 0.888(95%CI:0.812-0.964).Conclusion Our findings showed that Elevated NLR and decreased albumin were related with poor prognosis in patients with PAPE. The NLR and albumin were independent prognostic factor for PAPE.

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Incidence and Risk Factors Related to Symptomatic Venous Thromboembolic Events After Esophagectomy for Cancer

Abstract: Patients with ASA class III or IV and those who present a postoperative pneumopathy or ARDS seem to be at higher risk for VTE. Thus, current VTE screening and thromboprophylaxis for these patients might be inadequate and needs further investigation.

Cited by 24 publications

References 28 publications

Chylothorax as a Risk Factor for Thrombosis in Adults: A Proof-of-Concept Study

Chylothorax as a Risk Factor for Thrombosis in Adults: A Proof-of-Concept Study

Prognostic role of the preoperative neutrophil-to-lymphocyte ratio and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism

Prognostic role of preoperative neutrophil-to-lymphocyte ratio and albumin for 30-days mortality in patients with postoperative acute pulmonary embolism

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