Incidence and severity of iris pigmentation on latanoprost-treated glaucoma eyes

Abstract

Purpose The purpose of the present study was to investigate the incidence and severity of iridial pigmentation under latanoprost topical use on brown eyes in Taiwan.

The Clinical Impact and Incidence of Periocular Pigmentation Associated with either Latanoprost or Bimatoprost Therapy

“…17 In addition, Chiba and associates, and Chou and coworkers, noted that light brown irides of Asian patients also show increased pigmentation in approximately 30-40%. 18,19 The cause of iris pigmentation remains unknown. Stjernschantz and associates believed it was due to F prostanoid receptor agonism.…”

Incidence of a Latanoprost-Induced Increase in Iris Pigmentation in Japanese Eyes

“…Based only on similarity of iris color, the incidence of increased iris pigmentation due to latanoprost observed in Japanese eyes might also be applicable to eyes of non-Japanese Asians. 7 Wistrand et al 1 graded the increase in iris pigmentation as "not certain,""weak,""moderate," and "marked. ""Marked" was that noted by the patient or those closest to the patient.…”

Pressure Lowering Medications

“…Latanoprostinduced iris darkening (LIID) was found in higher frequency in heterogeneous hazel irises and homogeneous gray and blue irises are less likely to develop LIID in Caucasians (Alm et al, 2008). Japanese and South East Asians, in spite of having homogeneous dark brown irises, were more likely to develop LIID (Chiba et al, 2004;Chou et al, 2005). During phase III of a latanoprost study, latanoprost was postulated to have the ability to promote iris melanocyte proliferation .…”