Incidence and significance of psammoma bodies in Xp11.2 translocation renal cell carcinoma and papillary renal cell carcinoma

Abstract

The aim of the present study was to investigate the incidence and significance of psammoma bodies (PBs) in Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) and papillary renal cell carcinoma (PRCC). The presence of PBs, irregular calcifications, hyaline globules and nested architecture in RCC tissues, which included 47 cases of Xp11.2 tRCC and 95 cases of PRCC, was examined by two pathologists. Compared with PRCC, patients with Xp11.2 tRCC exhibited a higher frequency of PBs, hyaline globules and nested architecture. The presence of PBs in combination with the occurrence of a nested architecture achieved a specificity of 93.7% when diagnosing Xp11.2 tRCC. However, there were no significant differences in the overall survival between patients with and without PBs in both types of RCC. Therefore, the presence of PBs combined with nested architecture may provide guidance for the diagnosis of Xp11.2 tRCC; however, PBs cannot predict tumor behavior in Xp11.2 tRCC or PRCC.

Renal cell carcinoma associated with Xp11.2 translocation/transcription factor E3 gene fusion: A case report and literature review

“…These structures contain fibrovascular cores and often exhibit psammoma bodies, which are rarely seen in conventional ccRCC (27,28). The frequency of psammoma bodies has been reported as 50 and 62% in two clinicopathological studies (29,30). Although the tumor may have a relatively typical histological appearance, an accurate diagnosis still requires supporting immunohistochemical findings.…”

Clear cell renal cell carcinoma with focal psammomatous calcifications: a rare occurrence mimicking translocation carcinoma

“…13 These calcifications can also Ó 2022 John Wiley & Sons Ltd., Histopathology, 82, 684-690. be seen in some classical RCC subtypes (chromophobe RCC 14 ), as well as in some more recently characterised entities (eosinophilic solid and cystic RCC, 15 biphasic hyalinising psammomatous RCC, 16 NFmutated RCC 17 and RCC with sex-cord/ gonadoblastoma-like features 18 ). However, when encountering a renal cell carcinoma showing clear cell morphology and admixed psammomatous calcifications, the archetypal tumour type that comes to mind is the MiTF family translocation RCC (which includes TFE3 rearranged RCC and TFEB altered RCC [1][2][3][4][5][6][7][8][9] ). In fact, this is often considered a morphological clue to suspect a diagnosis of translocation RCC.…”

“…After finding such an index case, ironically a few months after this meeting by A.R.S. and following discussion with S.R.W., a former trainee of Dr Grignon who had collected a few such tumours, a multi-institutional search was conducted to gather specimens for a clinicopathological review of psammomatous calcifications (a well-described morphological feature of TFE3 rearranged RCC and TFEB altered RCC [1][2][3][4][5][6][7][8][9] ) identified in clear cell RCC.…”

Contrast‐Enhanced Ultrasound Features of Adult Xp11.2 Translocation Renal Cell Carcinoma

“…Previous studies on CT features of Xp11.2 tRCC have also confirmed that the renal lesions show circular or rim calcifications, which may be helpful for clinicians in diagnosing Xp11.2 tRCC. 13 , 14 One study reported that the formation of calcifications might be related to psammoma bodies in the renal lesions, 25 but the exact molecular mechanisms for calcification being more common in Xp11.2 tRCC are unclear. Additionally, the absence of color flow signals in renal lesions was confirmed on conventional US imaging, but peak enhancement on CEUS imaging in 55.9% of patients with Xp11.2 tRCC was iso‐enhancement in our study.…”