Incidence and survival of childhood central nervous system tumors: A report of the regional registry of childhood cancers in Auvergne-Limousin

Coll, Gabriel; Combes, Jean‐Damien; Isfan, Florentina; Rochette, Emmanuelle; Chazal, J.; Lemaire, Jean‐Jacques; Schlichting, Emmanuel De; Kanold, Justyna

doi:10.1016/j.neuchi.2015.01.005

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…Five-year survival was 71% or lower during 1970-1980, 29,30,32,50,51 and it increased slightly over three decades, from 78% in 1982 to 89% in 2009. 14,17,19,20,22-25,29-32,35,37,47,50,51,55 During 1982-1996, when the ICD-O-2 was in force, 56 5-year survival for astrocytoma ranged between 72% and 82% in most countries. 19,21,30-32,35,38,50,51 In the EUROCARE-4 study 23 (which used the ICD-O-3 12 ), 5-year survival for astrocytoma (1995-2002) in Central Europe, Northern Europe, Southern Europe, the United Kingdom, and Ireland was also approximately 75% when all behaviors were considered, but it decreased by 10% when nonmalignant tumors were excluded.…”

Section: Resultsmentioning

confidence: 99%

“…Five of the 22 studies using the definition “astrocytoma” (broad histology group) did not elucidate whether they included only malignant tumors or both malignant and nonmalignant tumors (Appendix Table A3). 15,17,20,29,35 Thirty-nine studies (83%) provided estimates of all-cause survival (ie, observed). Only eight provided relative survival estimates, adjusted for background mortality (Table 1).…”

Section: Resultsmentioning

confidence: 99%

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Worldwide Trends in Survival From Common Childhood Brain Tumors: A Systematic Review

Girardi

Allemani

Coleman

2019

JGO

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PURPOSE The histology of brain tumors determines treatment and predicts outcome. Population-based survival reflects the effectiveness of a health care system in managing cancer. No systematic review of worldwide variation and time trends in survival from brain tumors in children is currently available. PATIENTS AND METHODS We considered longitudinal, observational studies comprising children diagnosed with intracranial astrocytic or embryonal tumors. We searched six electronic databases from database inception to September 30, 2018, using complex search strategies. The outcome measure was 5-year survival, estimated through a time-to-event analysis. This study is registered with PROSPERO, number CRD42018111981. RESULTS Among 5,244 studies, we identified 47 eligible articles that provided 228 survival estimates. Only five studies were entirely or partially conducted in low-income or middle-income countries. Five-year survival from embryonal tumors increased from 37% in 1980 to approximately 60% in 2009. Although survival for medulloblastoma improved substantially (from 29% to 73% during 1959-2009), survival for primitive neuroectodermal tumors wavered over time (1973-2009) and between countries. Five-year survival from astrocytoma changed very little over the 27 years between 1982 and 2009 (from 78% to 89%). Interpretation of the literature was made difficult by the heterogeneity of study designs. CONCLUSION Survival has improved for embryonal tumors, but little change has been observed for astrocytic tumors. We found a striking gap in knowledge about survival from childhood brain tumor subtypes in middle-income and low-income countries, where half of these tumors are diagnosed. Larger studies are needed, including in under-represented countries and based on standardized data collection, to provide up-to-date survival estimates.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Worldwide Trends in Survival From Common Childhood Brain Tumors: A Systematic Review

Girardi

Allemani

Coleman

2019

JGO

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Embryonal tumors in Canadian children less than 36 months of age: results from the Canadian Pediatric Brain Tumor Consortium (CPBTC)

et al. 2017

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Embryonal tumors are a heterogeneous group of central nervous system (CNS) tumors whose subgroups have varying incidence and outcome. Despite these differences, they are often grouped as a single entity for study purposes. To date, there are no Canadian multi-institutional studies examining the incidence and outcome of all embryonal subtypes. The current study is an observational study reviewing embryonal tumors in all patients less than 36 months of age diagnosed with a CNS tumor in Canada from 1990 to 2005. Embryonal tumors accounted for 26.9% of all CNS tumors. Medulloblastomas were the highest proportion of the embryonal tumors at 61.5%. Atypical teratoid/rhabdoid tumors (AT/RT) had the second highest proportion of embryonal tumors at 18%. The proportion of primitive neuroectodermal tumors (PNET) was 16%, with 2.6 and 1.9% for congenital medulloepithelioma and ependymoblastoma tumors, respectively. AT/RT and PNET were more common in younger age groups. Medulloblastoma became more prevalent with increasing age, with its highest prevalence in the 25 to 36 month age group. Survival rates for our Canadian population at 18 and 24 months were 0.74 and 0.68 for medulloblastoma, 0.64 and 0.60 for PNET, and 0.36 and 0.29 for AT/RT, respectively. Overall, our data are comparable with published international rates for embryonal tumors. These incidence and outcome figures can guide future research into these rare tumors.

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Incidence and survival of central nervous system tumors in childhood and adolescence in Girona (Spain) 1990–2013: national and international comparisons

et al. 2019

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Incidence and survival of childhood central nervous system tumors: A report of the regional registry of childhood cancers in Auvergne-Limousin

Cited by 3 publications

References 45 publications

Worldwide Trends in Survival From Common Childhood Brain Tumors: A Systematic Review

Worldwide Trends in Survival From Common Childhood Brain Tumors: A Systematic Review

Embryonal tumors in Canadian children less than 36 months of age: results from the Canadian Pediatric Brain Tumor Consortium (CPBTC)

Incidence and survival of central nervous system tumors in childhood and adolescence in Girona (Spain) 1990–2013: national and international comparisons

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