Incidence and survival of desmoplastic melanoma in the United States, 1992-2007

Feng, Zhaoyong; Wu, Xiao‐Cheng; Chen, Vivien; Velie, Ellen M.; Zhang, Zhenzhen

doi:10.1111/j.1600-0560.2011.01704.x

Cited by 75 publications

(100 citation statements)

References 37 publications

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“…Thus, our results are in accordance with other studies that have reported a link between DM, chronic actinic damage, and LM. 2,3 We speculate that mDM is more likely to have risk factors and clinical and phenotypic characteristics similar to those of LM. In contrast to DM, desmoplastic nevus appears to be associated with younger age and development on non-sunexposed areas.…”

mentioning

confidence: 95%

Clinical and Dermoscopic Characteristics of Desmoplastic Melanomas

Jaimes¹,

Chen²,

Dusza³

et al. 2013

JAMA Dermatol

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mentioning

confidence: 95%

Clinical and Dermoscopic Characteristics of Desmoplastic Melanomas

Jaimes¹,

Chen²,

Dusza³

et al. 2013

JAMA Dermatol

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“…1 Features unique to this melanoma type include delayed diagnosis, deep invasion, increased perineural invasion and local recurrence. 2,3 George et al 4 recently reviewed 87 cases of desmoplastic melanoma and identified a significant difference in propensity for regional lymph node metastasis in the variant composed of a mixed population of cells, that is, cells resembling conventional melanoma in addition to spindled cells, compared with the variant composed predominantly of spindled cells, lending credence to the concept of subclassifying desmoplastic melanoma into mixed and pure subtypes.…”

mentioning

confidence: 99%

Mixed versus pure variants of desmoplastic melanoma: a genetic and immunohistochemical appraisal

et al. 2012

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Desmoplastic melanoma is subclassified into pure and mixed variants with a higher rate of lymph node metastasis in the latter. Given that reasons for these biological differences are not currently known, we investigated these subtypes with techniques that included genetic and immunohistochemical analyses of 43 cases of desmoplastic melanoma (24 pure, 19 mixed). Direct DNA sequencing was performed on BRAFV600E, RET gene (coding region on exon 11) and KIT (exons 11, 13 and 17). Immunohistochemical stains were performed with antibodies to markers of significance with respect to biological potential of nevomelanocytic proliferations and/or desmoplastic melanoma (Ki-67, CD117, nestin, clusterin, SOX10 and CD271/p75NTR). Polymorphism at the RET coding region (RETp) was noted in 33% of pure (8/24 cases) versus 24% of mixed (4/17 cases); BRAFV600E was absent in all cases of pure (0/24 cases) versus 6% of mixed (1/17 cases); no mutations were found in any of the cases on analyses of exons 11, 13 and 17 of the c-KIT gene (P ¼ NS for all). For immunohistochemical analyses of pure versus mixed: mean percentage of Ki-67 nuclear positivity was 5% (s.d. ¼ 5.6) versus 28% (s.d. ¼ 12.6, Po0.001); CD117 stained 26% (6/23 cases) versus 78% (14/18 cases, Po0.01); nestin stained 83% (n ¼ 19/23 cases) versus 89% (16/18 cases, P ¼ NS); clusterin stained 4% (1/23 cases) versus 6% (1/18 cases, P ¼ NS); SOX10 87% (20/23 cases) versus 94% (17/18 cases, P ¼ NS) and CD271 stained 61% (14/23 cases) versus 67% (12/18 cases, P ¼ NS). Increased CD117 staining in the mixed variant suggests that alterations in the KIT protein may be involved in tumor progression. In addition, the proliferative index of the mixed variant was higher than that of the pure variant.

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“…The median age of DM cases is approximately 60 years, and it is about 10 years later than that of conventional melanoma. [2] Besides DM occurs more often in men, and a maleto-female ratio is 2.3 in the United States. [2] It has a predilection for sun-damaged skin, and about 50% of DM are found on the head and neck, including face, ears, and scalp.…”

Section: Cutaneous Combined Desmoplastic Melanomamentioning

confidence: 99%