Incidence and survival rates and trends of skull Base chondrosarcoma: A Population-Based study

Dibas, Mahmoud; Doheim, Mohamed Fahmy; Ghozy, Sherief; Ros, Mohamed Hassan; El-Helw, Ghidaa Osama; Reda, Abdullah

doi:10.1016/j.clineuro.2020.106153

Cited by 35 publications

(31 citation statements)

References 20 publications

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“…The study conducted using the New York State Cancer Registry showed a higher incidence of CHS amongst Caucasians than in African American residents with an age-adjusted rate (AAR) of 0.19 and 0.11 per 100,000, respectively [ 9 ]. Racial differences were likewise observed in the skull base CHS incidence [ 10 ]. Concerning the histological subtypes, significant disparities in incidence were noted in non-conventional CHS.…”

Section: Introductionmentioning

confidence: 99%

Chondrosarcoma-from Molecular Pathology to Novel Therapies

Zając

Kopeć

Szostakowski

et al. 2021

Cancers

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Chondrosarcoma (CHS) is the second most common primary malignant bone sarcoma. Overall survival and prognosis of this tumor are various and often extreme, depending on histological grade and tumor subtype. CHS treatment is difficult, and surgery remains still the gold standard due to the resistance of this tumor to other therapeutic options. Considering the role of differentiation of CHS subtypes and the need to develop new treatment strategies, in this review, we introduced a multidisciplinary characterization of CHS from its pathology to therapies. We described the morphology of each subtype with the role of immunohistochemical markers in diagnostics of CHS. We also summarized the most frequently mutated genes and genome regions with altered pathways involved in the pathology of this tumor. Subsequently, we discussed imaging methods and the role of currently used therapies, including surgery and the limitations of chemo and radiotherapy. Finally, in this review, we presented novel targeted therapies, including those at ongoing clinical trials, which can be a potential future target in designing new therapeutics for patients with CHS.

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Section: Introductionmentioning

confidence: 99%

Chondrosarcoma-from Molecular Pathology to Novel Therapies

Zając

Kopeć

Szostakowski

et al. 2021

Cancers

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“…The enhancing cleaning efficacy was reported to be secondary to the ability of this combination to eradicate dentin debris and unnecessary waste layer, allow heating of the irrigating substance, and enhance the process of exchange of the irrigant within the canal. 4,24 The evidence further shows that the 5.25% sodium hypochlorite irrigation process should last 30 seconds-3 minutes. However, there are no clear guidelines or protocols about the exact duration of the irrigation process among the different studies in the literature.…”

Section: Discussionmentioning

confidence: 97%

Advantages and application of ultrasonic irrigation in endodontics

Abdulwahab

Alghamdi

Alshamrani

et al. 2021

Int J Community Med Public Health

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In the current practice, evidence shows that the currently used irrigant solutions (including sodium hypochlorite combined with and without chlorhexidine or ethylenediaminetetraacetic acid) cannot achieve full cleaning outcomes of the root canal. Accordingly, recent approaches were directed to innovate more efficacious modalities that can overcome the limitations of manual instrumentation and irrigation solutions. In this context, ultrasonic irrigation has been described in the literature as a favorable approach with significantly enhanced outcomes. We have provided evidence regarding the use of ultrasonic irrigation in endodontics. Our findings indicate that passive ultrasonic irrigation is more effective than manual instrumentation in eradicating debris and achieving favorable disinfection. Besides, it has been evidenced that the modality significantly reduces the time to achieve favorable treatment outcomes compared with the traditional approaches. It has been furtherly shown that more favorable outcomes were associated with the combined use of passive ultrasonic irrigation with manual instrumentation. Therefore, it has been suggested that manual instrumentation should be used at the initial phase to achieve adequate preparation, and passive ultrasonic irrigation should be used later on to achieve root canal cleaning.

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“…It has been evidenced that various migratory and local cells take part in these processes, including bone surface lining cells and fibroblasts. [20][21][22] Previous studies also demonstrated that during orthodontic treatment, specific immunocompetent cells migrate to the periodontal ligament. These cells include antigenpresenting cells (dendritic cells and macrophages), plasma cells, and lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Immunological and physiological responses related to orthodontic treatment

Bawyan

Baajajah

Alzahrani

et al. 2021

Int J Community Med Public Health

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Orthodontic treatment is usually approached to achieve better aesthetics by influencing tooth movement in different positions within the jaw. The application of mechanical forces during the process of treatment is the main responsible for these events. Remarkable changes in the vascularity of the underlying tissues were also reported to occur secondary to applying orthodontic forces. This significantly leads to the synthesis and release of many metabolites and signaling molecules. Furthermore, it might be associated with various immunological and physiological responses that enhance or deteriorate the prognosis. Therefore, the present study reviewed the literature to identify the different immunological and physiological responses secondary to orthodontic treatment. Our findings indicate that different immune cells and immunoglobulins are usually involved in orthodontic treatment-related events. Moreover, we found that cytokines and chemokines have an important role in the post-treatment inflammatory process, leading to bone resorption or bone formation. Various cytokines were reported in this context, including TNF-α, IFN-γ, IL-13, IL-12, IL-8, IL-6, and IL-1β. The roles of these modalities have been discussed based on their effects on bone remodeling following orthodontic treatment.

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Incidence and survival rates and trends of skull Base chondrosarcoma: A Population-Based study

Cited by 35 publications

References 20 publications

Chondrosarcoma-from Molecular Pathology to Novel Therapies

Chondrosarcoma-from Molecular Pathology to Novel Therapies

Advantages and application of ultrasonic irrigation in endodontics

Immunological and physiological responses related to orthodontic treatment

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