Incidence, Clinical Characteristics and Risk Factors for Adverse Outcome in Neonates With Late-onset Sepsis

Tsai, Ming-Horng; Hsu, Jen‐Fu; Chu, Shih-Ming; Lien, Reyin; Huang, Hsuan-Rong; Chiang, Ming-Chou; Fu, Ren-Huei; Lee, Chiang‐Wen; Huang, Yhu‐Chering

doi:10.1097/inf.0b013e3182a72ee0

Cited by 169 publications

(183 citation statements)

References 32 publications

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“…23 As in other studies, CoNS are the most common causative pathogens for HABSIs in our NICU. 2,3,[24][25][26][27][28] The relationship between CoNS HABSIs and vascular access is well known. Therefore, prevention strategies need to be directed at improving hand hygiene, skin-disinfection procedures, and so on.…”

Section: Trends In Pathogen Distributionmentioning

confidence: 99%

Healthcare-Associated Bloodstream Infections in a Neonatal Intensive Care Unit over a 20-Year Period (1992–2011): Trends in Incidence, Pathogens, and Mortality

Verstraete

Boelens

Coen

et al. 2014

Infect. Control Hosp. Epidemiol.

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Objective.To analyze trends in the incidence and pathogen distribution of healthcare-associated bloodstream infections (HABSIs) over a 20-year period (1992–2011).Design.Historical cohort study.Setting.Thirty-two-bed neonatal intensive care unit (NICU) in a tertiary referral hospital.Patients.Neonates with HABSIs defined according to the criteria of the National Institute of Child Health and Development (NICHD).Methods.A hospital-based ongoing surveillance program was used to identify HABSI cases in neonates. A distinction between definite or possible HABSI was made according to the NICHD criteria. Incidence, incidence densities (HABSIs per 1,000 hospital-days and HABSIs per 1,000 total parenteral nutrition–days), and case fatality rate were calculated. Logistic regression analysis was used to find time trends. Four periods of 5 years were considered when executing variance analysis.Results.In total, 682 episodes of HABSIs occurred on 9,934 admissions (6.9%). The median total incidence density rate was 3.1 (interquartile range, 2.2–3.9). A significant increasing time trend in incidence density was observed for the period 1995–2011 (P < .003). A significant decrease in the case fatality rate was found in the last 5-year period (P < .001). No neonate died following possible HABSIs, whereas the case fatality rate among neonates with definite HABSIs was 9.7%. Most HABSIs were caused by coagulase-negative staphylococci (n = 414 [60.7%]). A significant increase in Staphylococcus aureus HABSI was observed in the last 10-year period (P < .001).Conclusions.An increase in incidence density rate occurred, while the case fatality rate dropped. Better perinatal care could be responsible for the latter. A decrease in days before infection and a high incidence of coagulase-negative Staphylococcus HABSIs indicate the need for vigorous application of evidence-based prevention initiatives, in particular for catheter care.

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Section: Trends In Pathogen Distributionmentioning

confidence: 99%

Healthcare-Associated Bloodstream Infections in a Neonatal Intensive Care Unit over a 20-Year Period (1992–2011): Trends in Incidence, Pathogens, and Mortality

Verstraete

Boelens

Coen

et al. 2014

Infect. Control Hosp. Epidemiol.

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“…Его цели -исправ-ление кифотической деформации, воссоздание опорности передней колонны позвоночника и обеспечение максимально приближенного к фи-зиологическому росту вновь созданно-го позвоночника. При этом изолиро-ванная задняя фиксация позвоночника без реконструкции передней колон-ны может быть недостаточна для про-филактики прогрессирования кифоза в отдаленном периоде [29].…”

Section: заключениеunclassified

“…Его причиной может быть различный спектр биопатогенов, чаще всего коа-гулазонегативные стафилококки, реже грамотрицательные палочки и гри-бы [8,11,13,17,18,20,23,28,29,32,33]. Частота ПСН обратно пропорци-ональна весу новорожденного [12].…”

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“…Частота ПСН обратно пропорци-ональна весу новорожденного [12]. Другие факторы риска -длительное использование инвазивных процедур (катетеризация сосудов, ИВЛ), позд-нее начало грудного вскармливания, длительное парентеральное питание, хирургические вмешательства, сопут-ствующие сердечно-сосудистые забо-левания и патология органов дыхания [11,18,24,28,29].…”

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Vertebral Complications of Late-Onset Neonatal Sepsis

Mushkin¹,

Pershin²,

Naumov³

et al. 2016

Hir. pozvonoč.

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“…Neonatal late-onset septicemia (LOS) is a common complication of infants under prolonged hospitalization in the neonatal intensive care unit (1). LOS occurs in ~10% of all neonates in neonatal intensive care units and up to 21% of very low birth weight infants experience an episode of LOS (2,3).…”

Section: Introductionmentioning

confidence: 99%

16S rDNA PCR-DGGE and sequencing in the diagnosis of neonatal late-onset septicemia

Liu

et al. 2015

Molecular Medicine Reports

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Abstract. The 16S rDNA polymerase chain reaction (PCR)-denaturing gradient gel electrophoresis (DGGE) and sequencing method has been demonstrated to be valuable in detecting pathogens in the blood of patients suffering from fever or neutropenia. However, its use in the diagnosis of neonatal late-onset septicemia (LOS) has not yet been reported. The aim of the present study was to investigate the efficiency of this method in detection of the type of bacterial infection in neonatal LOS. Blood specimens from 60 neonates in whom LOS was suspected were collected. Fourteen culture positive blood samples and 24 spiked 'infected' blood samples were analyzed by the 16S rDNA PCR-DGGE and sequencing method or by pathogen-specific PCR. Only in 5 of the 14 cases did the results of 16S rDNA PCR-DGGE and sequencing match with the results of blood culturing. In the other 9 cases, the blood culture failed to detect bacteria, such as Neisseria sp. and Moraxella sp., which were detected by 16S rDNA PCR-DGGE and sequencing. Furthermore, the 16S rDNA PCR-DGGE and sequencing failed to detect blood culture-proven bacteria, such as Klebsiella pneumonia. A competitive inhibitory effect in 16S rDNA PCR amplification may lead to the discrepancy between pathogen-specific PCR and spiked 'infected' blood samples. When a certain species of bacteria was detected by 16S rDNA PCR, the competitive inhibitory effect presented a higher sensitivity in detecting this species in the blood samples that contained bacterial DNA only from this species compared with the blood samples that were blended with other bacterial DNAs. In conclusion, 16S rDNA PCR-DGGE and sequencing can detect a more comprehensive spectrum of pathogens than blood culture. However, the competitive inhibitory effect, which may lead to false negative results should be taken into consideration when the 16S rDNA PCR-DGGE and sequencing method is applied to the diagnosis of neonatal LOS.

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Incidence, Clinical Characteristics and Risk Factors for Adverse Outcome in Neonates With Late-onset Sepsis

Cited by 169 publications

References 32 publications

Healthcare-Associated Bloodstream Infections in a Neonatal Intensive Care Unit over a 20-Year Period (1992–2011): Trends in Incidence, Pathogens, and Mortality

Healthcare-Associated Bloodstream Infections in a Neonatal Intensive Care Unit over a 20-Year Period (1992–2011): Trends in Incidence, Pathogens, and Mortality

Vertebral Complications of Late-Onset Neonatal Sepsis

16S rDNA PCR-DGGE and sequencing in the diagnosis of neonatal late-onset septicemia

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