Incidence, Clinical Manifestations, and Severity of Juvenile Idiopathic Arthritis Among Maori and Pacific Island Children

Concannon, Anthony; Reed, Peter; Ostring, Genevieve

doi:10.1002/acr.23757

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…A study of Maori or Pacific Island children in New Zealand found a higher frequency of RF positivity (although not anti-CCP positivity) than in children of European background, as well as increased likelihood of joint space narrowing or erosions on radiographs. The proportion of Maori children with JIA with erosions on radiographs (19%) was similar to the proportion in our study (17.9%) (19).…”

Section: Discussionsupporting

confidence: 89%

“…However, given the small number of cases and wide confidence intervals in this study, we cannot determine whether this difference is due to chance. A study of the Maori population in New Zealand found lower incidence of JIA than in children of European ancestry, although a greater number of poor prognostic factors was identified in the Maori children (19). A study of a diverse population by Kaiser Permanente in Northern California found an age-adjusted JIA prevalence of 44.7 per 100,000, which is slightly lower but only included the population of age ≤15 years (18).…”

Section: Discussionmentioning

confidence: 98%

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Prevalence of Juvenile Idiopathic Arthritis in the Alaska Native Population

Khodra

Stevens²,

Ferucci

2020

Arthritis Care & Research

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Objective. To determine the prevalence and clinical characteristics of juvenile idiopathic arthritis (JIA) in Alaska Native children.Methods. Potential cases of JIA were identified by querying administrative data from hospitals and clinics in the Alaska Tribal Health System for codes possibly identifying JIA. Medical record abstraction was performed to confirm criteria met for JIA, demographic and clinical characteristics, and treatment patterns. Individuals age ≤18 years with a confirmed diagnosis of JIA were included. The denominator for prevalence was the 2015 Alaska Area Indian Health Service user population age of ≤18 years.Results. The unadjusted prevalence of JIA in Alaska Native children was 74.6 per 100,000 (age-adjusted 79.0 per 100,000). JIA was more common in females than males (unadjusted prevalence 105.8 versus 45.0 per 100,000). Oligoarthritis was the most common subtype (31% of cases), but polyarthritis and enthesitis-related arthritis were also common (26% and 24% of cases, respectively), with a notably high prevalence of enthesitis-related arthritis. The median age at diagnosis was 9 years. Of the combined cohort with results available, 56% were antinuclear antibody positive, 23% were rheumatoid factor positive, 19% were anti-cyclic citrullinated peptide antibody positive, and 57% had the presence of HLA-B27. Uveitis had been diagnosed in 16% of cases.Conclusion. The prevalence of JIA in Alaska Native children may be higher than the general US population. Enthesitis-related arthritis makes up a higher proportion of cases than in other populations described likely because of the high prevalence of HLA-B27 in this population.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Prevalence of Juvenile Idiopathic Arthritis in the Alaska Native Population

Khodra

Stevens²,

Ferucci

2020

Arthritis Care & Research

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“…17 In addition, genetic variability has been postulated as a possible contributor to the differences in diagnostic disease severity for Maori and Pacific Island children with Juvenile Idiopathic Arthritis which were independent of socio-economic status. 13…”

Section: Discussionmentioning

confidence: 99%

“…Maori and Pacific Island children with Juvenile Idiopathic Arthritis more likely to present with poor prognostic features including cervical spine involvement, erosive change and rheumatoid factor positive disease. 13 Maori and Pacific Island children also have a higher incidence of juvenile systemic lupus erythematosus with a higher frequency of lupus nephritis and more severe renal lesions compared to European children. 14 There are no data describing the incidence and clinical characteristics of JDM among New Zealand children.…”

Section: What This Paper Addsmentioning

confidence: 99%

“…Previous studies of rheumatic disease in New Zealand children have demonstrated ethnic differences in incidence and clinical manifestations. Maori and Pacific Island children with Juvenile Idiopathic Arthritis more likely to present with poor prognostic features including cervical spine involvement, erosive change and rheumatoid factor positive disease 13 . Maori and Pacific Island children also have a higher incidence of juvenile systemic lupus erythematosus with a higher frequency of lupus nephritis and more severe renal lesions compared to European children 14 .…”

mentioning

confidence: 99%

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Incidence, severity and clinical manifestations of juvenile dermatomyositis among Maori and Pacific Island compared to European children

Concannon

Han

2021

J Paediatrics Child Health

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To describe the incidence, demographics, diagnostic clinical manifestations and long-term outcomes of juvenile dermatomyositis (JDM) in Maori and Pacific Island compared to European children. Methods: A chart review was conducted of children with JDM seen by the Starship Rheumatology service between 2000 and 2020. Diagnostic clinical manifestations, demographics, disease course and significant complications were collated. The incidence, clinical manifestations and severity of JDM were determined and compared between ethnic groups, in particular Maori and Pacific Island, and European children. Results: The overall incidence of JDM was 0.24/100 000 per year with no significant ethnic variation. Maori children were less likely to achieve a clinical response (71 vs. 100%, P = 0.08), Maori and Pacific less likely to achieve clinical remission (56 vs. 40%, P = 0.69), with Maori (71 vs. 44%, P = 0.37) and Maori and Pacific (60 vs. 44%, P = 0.69) children more likely to follow a chronic course compared to European children. Calcinosis (50 vs. 13%, P = 0.07), cutaneous vasculopathy (30 vs. 0%, P = 0.05) and interstitial lung disease (30 vs. 6%, P = 0.26) were more common in Maori and Pacific compared to European children. Conclusion:The incidence of JDM among a cohort of New Zealand children was established, with Maori and Pacific children more likely to experience a chronic continuous disease course, calcinosis, cutaneous vasculopathy and interstitial lung disease compared to European children.

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The incidence and prevalence of juvenile idiopathic arthritis differs between ethnic groups in England

Beesley,

Hyrich,

Humphreys

2023

Rheumatology

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Objectives Juvenile Idiopathic Arthritis (JIA) is a heterogenous group of rare autoimmune disorders characterised by chronic joint inflammation of unknown aetiology with onset under 16years. Accurate estimates of disease rates help understand impacts on individuals and society, and provide evidence for health service planning and delivery. This study aimed to produce the first national estimates of incidence and prevalence by ethnic group using electronic health records. Methods Data from the Clinical Practice Research Datalink (CPRD) Aurum, a primary care electronic health record database in England, were used to estimate the incidence and prevalence of JIA by ethnic group amongst children and young people aged under 16 years between 2003 and 2018, with cases validated using Hospital Episode Statistics (HES). Chi square was used to test the difference in proportions compared to the ethnic distribution of England. Results A total of 424 incident cases of JIA were identified, 389 validated using HES records. Incidence of JIA was higher amongst those of White ethnic group (6.2 per 100,000 population) compared to Mixed (3.0 per 100,000), Asian (2.7 per 100,000) and Black (2.9 per 100,000) communities. The ethnic group distribution of cases differed significantly compared to the general population (p < 0.0001). Conclusion Incidence and prevalence of JIA differs between ethnic groups, and is different from the population. This is likely to be due to a combination of genetic and equity factors. Further research to understand the underlying cause of these differences is important, to enable targeted interventions and appropriate service provision.

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Incidence, Clinical Manifestations, and Severity of Juvenile Idiopathic Arthritis Among Maori and Pacific Island Children

Cited by 5 publications

References 10 publications

Prevalence of Juvenile Idiopathic Arthritis in the Alaska Native Population

Prevalence of Juvenile Idiopathic Arthritis in the Alaska Native Population

Incidence, severity and clinical manifestations of juvenile dermatomyositis among Maori and Pacific Island compared to European children

The incidence and prevalence of juvenile idiopathic arthritis differs between ethnic groups in England

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