Incidence, diagnosis and treatment of sinusitis in children and adolescents after hematopoietic stem cell transplantation

Утимишева, Е; Dolgov, O. I.; Paina, Olesya V.; Ekushov, Kirill Alexandrovich; Vitrischak, Alina; Смирнов, Б. И.; Zubarovskaya, Ludmila; Karpishchenko, S. А.; Afanasyev, Boris

doi:10.18620/ctt-1866-8836-2019-8-1-46-53

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Р. М. Горбачевой. В частности, опубликованы результаты исследования Е. С. Утимишевой, посвященного синуситам у детей и подростков после ТГСК, а также результаты оценки возможности пункционного лечения синуситов в условиях цитопении [17][18][19]. Остальная патология ЛОРорганов описана в виде отдельных клинических наблюдений, что не позволяет судить о ее частоте.…”

Section: Rossiiskaya Otorinolaringologiyaunclassified

Prevalence of acute inflammatory otorhinolaryngological diseases in hematopoietic stem cell transplant recipients

Dolgov¹,

Karpishchenko²,

Rodneva³

et al. 2021

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The article presents the results of a study of the prevalence of acute (exacerbation of chronic) otorhinolaryngological pathology at the stages of hematopoietic stem cell transplantation (HSCT). The frequency of the studied pathology was assessed at the stage of pre-transplant screening, at the stage before graft engraftment and at the stage after graft engraftment up to 180 days. The study included 1129 cases of HSCT performed at the Raisa Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation from January 2017 to December 2019. The median age of the patients was 27 years (min – 0,36, max – 73,22). Allogeneic HSCT was performed in 784 (69,4%) cases, autologous HSCT in 345 (30,6%) cases. The power of the study was 0,95. A comparative analysis using the Pearson χ2 criterion revealed that infectious complications were significantly more frequent with allo-HSCT than with auto-HSCT, both at the stage before engraftment (χ2 = 21.8 at p <0.0001) and at the stage after graft engraftment (χ2 = 224,78 at p < 0.0001). It was also shown that acute symptoms of rhinosinusitis prevailed at all stages of HSCT, reaching 5,3% (95% CI 5.0% – 5,6%) at the stage before transplantation, 3,01% (95% CI 2, 8% – 3,2%) at the stage before engraftment, and 8,13% (95% CI 7,67% – 8,60%) at the stage after engraftment. At the stage before engraftment, rhinosinusitis competed with the diagnosis of acute pharyngitis, with a frequency of 34 (36,17%) and 33 (35,11%), respectively. Acute rhinosinusitis, acute rhinitis, and strep throat were the most common diagnoses at all three stages assessed. The rest of the acute inflammatory otorhinolaryngological diagnoses were observed in less than 2% of cases each. Establishing the frequency of acute otorhinolaryngological pathology at the stages of HSCT; understanding the most relevant nosologies. This allows us to focus on further study of the factors of their development, prevention and treatment.

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Section: Rossiiskaya Otorinolaringologiyaunclassified

Prevalence of acute inflammatory otorhinolaryngological diseases in hematopoietic stem cell transplant recipients

Dolgov¹,

Karpishchenko²,

Rodneva³

et al. 2021

View full text Add to dashboard Cite

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CFAP43 variant in persistent respiratory symptoms after hematopoietic cell transplantation

Nagasawa,

Nishimura,

Yamada

et al. 2024

Hum Genome Var

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We describe a case of RAS-associated autoimmune leukoproliferative disease with primary ciliary dyskinesia (PCD)-like symptoms, such as recurrent pneumonia, sinusitis, and otitis media, that occurred 7 years after hematopoietic cell transplantation. Whole-exome sequencing revealed a heterozygous CFAP43 nonsense variant. Environmental factors related to hematopoietic cell transplantation may have led to PCD symptoms in this patient with this variant. Genetic screening can help avoid subsequent complications during patient management.

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Incidence, diagnosis and treatment of sinusitis in children and adolescents after hematopoietic stem cell transplantation

Cited by 2 publications

References 12 publications

Prevalence of acute inflammatory otorhinolaryngological diseases in hematopoietic stem cell transplant recipients

Prevalence of acute inflammatory otorhinolaryngological diseases in hematopoietic stem cell transplant recipients

CFAP43 variant in persistent respiratory symptoms after hematopoietic cell transplantation

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