Incidence, impact and risk factors for multidrug-resistant organisms (MDRO) in patients with major trauma: a European Multicenter Cohort Study

Nohl, André; Hamsen, Uwe; Jensen, Kai Oliver; Sprengel, Kai; Ziegenhain, Franziska; Lefering, Rolf; Dudda, Marcel; Schildhauer, Thomas A.

doi:10.1007/s00068-020-01545-4

Cited by 14 publications

(4 citation statements)

References 31 publications

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“…The findings in this study revealed that the area of care had a statistically significant association with MDRO infections, with the ICU having higher odds for developing MDRO infection than the surgical unit. Another recently published multicenter study assessed the incidence, impact, and risk factors for MDRO infections in patients with major trauma and reported that being male, injury severity score (ISS), administration of packed red blood cells, ICU stay > 48 h, and mechanical ventilation were the main risk factors for MDRO infection; moreover, MDRO infection was associated with worse patient outcome, Gram-negative bacteria outnumber gram-positive bacteria in patients with numerous injuries ( Nohl et al, 2020 ).In the same previous study found a link between injury severity and MDRO detection, with higher the ISS, the greater the likelihood of positive MDRO detection. Notably, in this study, a low hemoglobin level was linked to infection with MDROs.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of risk factors associated with multidrug-resistant organism infections among patients admitted in a tertiary hospital - a retrospective study

Alsehemi¹,

Alharbi²,

Al-amash³

et al. 2023

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

“…Bacterial resistance is a global health threat and has intensified with the inappropriate use of antibiotics ( Nohl et al, 2020 ). Multidrug resistant organisms (MDROs) occurs when microorganisms develop antibiotic-resistance and evolve in response to antibiotics misuse and overuse, among other factors.…”

Section: Introductionmentioning

confidence: 99%

Assessment of risk factors associated with multidrug-resistant organism infections among patients admitted in a tertiary hospital - a retrospective study

Alsehemi¹,

Alharbi²,

Al-amash³

et al. 2023

Saudi Pharmaceutical Journal

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“…It is well known that patients with low immunity have an increased chance of infection with microbes, including MDROs. Previous research has revealed that low albumin and hemoglobin levels, often considered as evidence of low immunity, are risk factors for clinical infection ( 14 , 15 ). However, the results of the present study did not identify low albumin and hemoglobin levels as risk factors for MDROs infection.…”

Section: Discussionmentioning

confidence: 99%

Infection with multi‑drug resistant organisms in patients with limb fractures: Analysis of risk factors and pathogens

Sun,

Dong,

Zhao

et al. 2023

Biomed Rep

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Infection with multi-drug resistant organisms (MDROs) has emerged as a global problem in medical institutions. Overuse of antibiotics is the main cause of drug resistance. Notably, the incidence of infection with MDROs increases in patients with limb fractures who have undergone invasive surgery. The present study aimed to analyze the risk factors for postoperative MDROs infection in a cohort of patients with limb fractures. A retrospective study was performed on the data of patients with fractures between January 2020 and August 2022. Postoperative surgical site infection occurred in 114 patients in total, of which 47 were infected with MDROs. Univariate logistic regression analysis and multivariate binary logistic regression were used to confirm the associations between independent risk factors and MDRO infection. A total of 155 bacteria were collected from patients with MDROs infection and patients with non-MDROs infection, of which 66.5% were gram-positive bacteria and 33.5% were gram-negative. Staphylococcus aureus accounted for 26.5% of the 155 pathogens. MDROs, such as methicillin-resistant S. aureus and extended-spectrum β-lactamases-positive gram-negative bacillus, were detected after antibiotic treatment. Univariate analysis indicated that the number of antibiotics administered, being bedridden, repeat infection, operative time and repeated operation were different in the two groups. In addition, univariate logistic analysis indicated that being bedridden (OR, 3.98; P=0.001), administration of >2 antibiotics (OR, 2.42; P=0.026), an operative time of >3 h (OR, 3.37; P=0.003), repeated infection (OR, 3.08; P=0.009) and repetition of procedures (OR, 2.25; P=0.039) were individual risk factors for MDRO infection. Multivariate analysis showed that being bedridden (OR, 2.66; P=0.037), repeated infection (OR, 4.00; P=0.005) and an operative time of >3 h (OR, 2.28; P=0.023) were risk factors of MDRO infection. In conclusion, constrained antibiotic use, shortened operative time and increased activity duration can effectively prevent surgical-site infection with MDROs in patients with fractures.

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“…Antibiotics are very effective in preventing and treating bacterial infections. However, with the misuse of antibiotics, some bacteria have developed resistance (Bombaywala et al 2021; Larsson and Flach 2022), and even multidrug-resistant bacteria have emerged (Nohl et al 2020). Unfortunately, the development of conventional antibiotics has not kept pace with the rate at which bacteria are developing resistance.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Cecropin A (1–7) Analogs with DNA Analyzed by Multi-spectroscopic Methods

Yuan,

Wang,

Fang

et al. 2024

Protein J

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Cecropin A is a cationic antimicrobial peptides which contain lots of basic amino acids. To understand the effect of basic amino acids on cecropin A, analogues CA2, CA3 and CA4 which have more arginine or lysine at the Nterminal or C-terminal were designed and synthesized. The interaction of cecropin A and its analogs with DNA was studied using ultraviolet-visible spectroscopy, uorescence spectroscopy and circular dichroism spectroscopy. Multispectral analysis showed that basic amino acids improved the interaction between the analogues and DNA.The interaction between CA4 and DNA is most pronounced. Fluorescence spectrum indicated that Ksv value of CA4 is 1.19×10 5 L•mol − 1 compared to original peptide cecropin A of 3.73×10 4 L•mol − 1 . The results of antimicrobial experiments with cecropin A and its analogues showed that basic amino acids enhanced the antimicrobial effect of the analogues. The antimicrobial activity of CA4 against E. coli was 8-fold higher than that of cecropin A. The importance of basic amino acid in peptides is revealed and provides useful information for subsequent studies of antimicrobial peptides.

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Incidence, impact and risk factors for multidrug-resistant organisms (MDRO) in patients with major trauma: a European Multicenter Cohort Study

Cited by 14 publications

References 31 publications

Assessment of risk factors associated with multidrug-resistant organism infections among patients admitted in a tertiary hospital - a retrospective study

Assessment of risk factors associated with multidrug-resistant organism infections among patients admitted in a tertiary hospital - a retrospective study

Infection with multi‑drug resistant organisms in patients with limb fractures: Analysis of risk factors and pathogens

Interaction of Cecropin A (1–7) Analogs with DNA Analyzed by Multi-spectroscopic Methods

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