Incidence in South-west Scotland of hepatitis B surface antigen in the liver of patients with hepatocellular carcinoma.

Turbitt, Marlyn L.; Patrick, R. S.; Goudie, R. B.; Buchanan, W. M.

doi:10.1136/jcp.30.12.1124

Cited by 24 publications

(12 citation statements)

References 15 publications

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“…It seems that the southern African Black with HCC may be more likely than other patients with this tumour to have the antigen demonstrable in malignant hepatocytes (2255%). As was the case in other studies (Hadziyannis et al, 1976;Nayak et al, 1977;Turbitt et al, 1977) when HBsAg was demonstrable in malignant hepatocytes, the quantities were small. The antigen had a different distribuition in the tumour cells, occupying a perinuclear position.…”

Section: Hbsag In Serumsupporting

confidence: 65%

“…By contrast, in Scotland, where both HCC and chronic HBs antigenaemia are infrequent, only 10% of tissues stained positively for HBsAg (Turbitt et al, 1977). The prevalenice of tissue 1H BsAg in southern African Blacks with this tumour lies between the two extremes, which is intriguing because the prevalence of HBs antigenaemia is higher in the African patients than in most or all of the other H1CC populations studied (Kew, 1978).…”

Section: Hbsag In Serummentioning

confidence: 99%

“…Detection of these markers in the non-tumorous liver tissue, whether this is normal or cirrhotic, and especially in the malignant cells themselves, might provide more direct evidence for an oncogenic role of the virus. Some information in this regard is already available (Tan et al, 1977;Nayak et al, 1977;Turbitt et al, 1977;Trevisan et al, 1978 (Ray & Desmet, 1975); peroxidase and anti-peroxidase (Burns, 1975;Busachi et al, 1978); orcein staining (Shikata et al, 1974). For control purposes, a known positive and a known negative slide were included in each batch of slides stained.…”

mentioning

confidence: 99%

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Hepatitis-B surface antigen in tumour tissue and non-tumorous liver in black patients with hepatocellular carcinoma

Kew¹,

Ray²,

Desmet³

et al. 1980

Br J Cancer

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Section: Hbsag In Serumsupporting

confidence: 65%

Section: Hbsag In Serummentioning

confidence: 99%

mentioning

confidence: 99%

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Hepatitis-B surface antigen in tumour tissue and non-tumorous liver in black patients with hepatocellular carcinoma

Kew¹,

Ray²,

Desmet³

et al. 1980

Br J Cancer

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“…Hepatitis B virus has been demonstrated in human liver sections similarly preserved for up to 18 years. 14,30,43, 49 Establishing the stability of canine adenovirus in paraffin-embedded tissue, however, was necessary before seeking the virus in livers with inflammatory lesions of unknown etiology. An immunoperoxidase method was used because of its several advantages over the more conventional immunofluorescence technique.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Detection of Canine Adenovirus in Paraffin Sections of Liver

et al. 1986

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Abstract. An avidin-biotin immunoperoxidase procedure was optimized for detection of canine adenoviral antigens in formalin-fixed, paraffin-embedded liver. Long-term stability of viral antigen was shown by successful demonstration of virus in liver tissue preserved up to six years from dogs with infectious canine hepatitis. This immunohistochemical stain was applied to sections from livers with a wide range of inflammatory lesions. Examination of sections from 53 dogs yielded five livers with small amounts of adenovirus. An additional virus-positive liver was identified from a dog with no hepatic inflammation. Although a cause and effect relationship remains to be determined, these findings suggest a possible connection between canine adenovirus and spontaneous chronic hepatitis.

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“…Also, HBsAg is often detected at the periphery of the tumour and usually has a perinuclear distribution (Nazarewicz et al . 1977; Turbitt et al . 1977; Trevisan et al .…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B virus and hepatocellular carcinoma

Arbuthnot

Kew

2001

Int J Experimental Path

261

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Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma (HCC). Individuals who are chronic carriers have a greater than 100-fold increased relative risk of developing the tumour. Several mechanisms of HBV-induced HCC have been proposed. Integration of HBV DNA into the genome of hepatocytes occurs commonly, although integration at cellular sites that are important for regulation of hepatocyte proliferation appears to be a rare event. Functions of the HBx protein are also potentially oncogenic. These include transcriptional activation of cellular growth regulatory genes, modulation of apoptosis and inhibition of nucleotide excision repair of damaged cellular DNA. The effects of HBx are mediated by interaction with cellular proteins and activation of cell signalling pathways. Variations in HBV genome sequences may be important in hepatocarcinogenesis, although their significance has not yet been completely elucidated. Necroinflammatory hepatic disease, which often accompanies chronic HBV infection, may contribute indirectly to hepatocyte transformation in a number of ways, including by facilitating HBV DNA integration, predisposing to the acquisition of cellular mutations and generating mutagenic oxygen reactive species. Although HCC is a malignancy with a poor prognosis, the availability of an effective vaccine against HBV infection, and its inclusion in the Expanded Programme of Immunization of many countries, augurs well for the eventual elimination of HBV-associated HCC.

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Incidence in South-west Scotland of hepatitis B surface antigen in the liver of patients with hepatocellular carcinoma.

Cited by 24 publications

References 15 publications

Hepatitis-B surface antigen in tumour tissue and non-tumorous liver in black patients with hepatocellular carcinoma

Hepatitis-B surface antigen in tumour tissue and non-tumorous liver in black patients with hepatocellular carcinoma

Immunohistochemical Detection of Canine Adenovirus in Paraffin Sections of Liver

Hepatitis B virus and hepatocellular carcinoma

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