Incidence, management and outcome of raised intraocular pressure in childhood-onset uveitis at a tertiary referral centre

Tan, Shi Zhuan; Yau, Kenneth; Steeples, Laura R; Ashworth, Jane; Fenerty, Cecilia; Jones, Nicholas P.

doi:10.1136/bjophthalmol-2018-312498

Cited by 5 publications

(2 citation statements)

References 23 publications

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“… 2 , 55 , 105 These occur as a sequelae of either uncontrolled inflammation or injudicious use of topical steroids. 9 , 106 – 108 Thus, adequate control of ocular inflammation is key to good visual outcome for the majority of children. This often requires the use of powerful immunomodulators or immunosuppressive agents, in order to limit the dependence on the topical and systemic corticosteroids needed to control disease.…”

Section: Managing Childhood Uveitismentioning

confidence: 99%

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Paediatric autoimmune and autoinflammatory conditions associated with uveitis

2020

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Childhood uveitis comprises a collection of heterogenous ocular phenotypes which are associated with a diverse range of childhood autoimmune and autoinflammatory disorders. Of these genetic and/or acquired disorders, juvenile idiopathic arthritis is the most common, affecting 30-80% of children with uveitis. Up to a third of children with uveitis have ‘isolated’ idiopathic disease and do not have an associated systemic disease which manifests in childhood. However, uveitis may be the presenting manifestation of disease; thus, the apparently well child who presents with uveitis may have isolated idiopathic disease, but they may have an evolving systemic disorder. The diagnosis of most of the associated disorders is reliant on clinical features rather than serological or genetic investigations, necessitating detailed medical history taking and systemic examination. Adequate control of inflammation is key to good visual outcomes, and multidisciplinary care is key to good broader health outcomes.

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Section: Managing Childhood Uveitismentioning

confidence: 99%

“… 2 , 5 , 6 Inflammatory sequelae such as glaucoma and cataract are more challenging to manage in children. 7 – 9 There are also the additional obstacles of amblyopia, managing a chronic disease in a developing child and the difficulties of effective transition to adult care services.…”

Section: Introductionmentioning

confidence: 99%