Abstract:Purpose: Several small studies have reported that acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection for patients with non-small cell lung cancer, though the incidence rate is unclear. Methods: We examined our institutional data and performed a search of the MEDLINE database for publications regarding AE of IIP following surgery for lung cancer. Studies reporting the incidence rates of IIP and AE were included. Results: Eleven studies including our institutional d… Show more
“…Second, the study population was treated at a single center and may therefore lack external validity. Only 2.3% of the IIP patients had acute exacerbation in this study; in contrast, previous studies have reported that acute exacerbation occurred in 9.3% to 15.8% of IIP patients [4,31]. This finding may be due to differences in the diagnostic criteria and perioperative management of IIPs among studies.…”
“…Second, the study population was treated at a single center and may therefore lack external validity. Only 2.3% of the IIP patients had acute exacerbation in this study; in contrast, previous studies have reported that acute exacerbation occurred in 9.3% to 15.8% of IIP patients [4,31]. This finding may be due to differences in the diagnostic criteria and perioperative management of IIPs among studies.…”
“…[14][15][16] It has been reported that the presence of ILD increased the incidence of postoperative acute respiratory distress syndrome and acute exacerbations [17][18][19] and that ILD was a poor prognostic factor after surgery. [20][21][22][23][24] Thus, lung cancer patients with ILD are not good candidates for surgical resection.…”
Pre-existing ILD was a significant risk factor for symptomatic and severe RP. Prescreening for ILD findings is important for determining the radiation pneumonitis risk when planning SBRT.
“…AE of IP has been shown to be a fatal postoperative morbidity [1][2][3][4][5][6], while BPF leading to PP has also been reported as a cause of postoperative death in Japanese patients [7]. The present findings indicate that IP is likely a risk factor for PP (borderline significance) and are the first to show that the presence of PP itself increases the risk of AE following lung cancer resection surgery.…”
Section: Discussionmentioning
confidence: 54%
“…Patients with IP comprise 4-5 % of those with lung cancer who undergo such an operation, while AE occurs in 9-15 % of patients with idiopathic IP undergoing lung cancer resection and the rate of mortality in those is approximately 50 % [4,5]. In Japan, AE is a major postoperative cause of death following lung resection, comprising 27.4 % of all perioperative mortality cases, while postoperative pyothorax (PP) and bronchopleural fistula (BPF) following lung cancer resection are the cause of perioperative death in 9.7 % of reported cases [7].…”
Section: Introductionmentioning
confidence: 99%
“…Acute exacerbation (AE) in patients with idiopathic interstitial pneumonia (IP), mostly comprised of idiopathic pulmonary fibrosis cases is a potentially fatal postoperative complication following lung surgery [1][2][3][4][5][6]. Patients with IP comprise 4-5 % of those with lung cancer who undergo such an operation, while AE occurs in 9-15 % of patients with idiopathic IP undergoing lung cancer resection and the rate of mortality in those is approximately 50 % [4,5].…”
PP was found to be a significant risk factor for postoperative AE in lung cancer patients undergoing a pulmonary resection. Since IP itself is likely a risk factor for PP, prevention of BPF is important for patients with IP, as it can lead to PP.
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