Incidence of acute kidney injury after teicoplanin– or vancomycin– and piperacillin/tazobactam combination therapy: A comparative study using propensity score matching analysis

Sazanami, Kohei; Inose, Ryo; Yagi, T.; Dote, Satoshi; Horiuchi, Nozomu; Kobayashi, Yuka

doi:10.1016/j.jiac.2021.08.012

Cited by 4 publications

(7 citation statements)

References 21 publications

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“…Larger perfusion and higher concentrations of excreted compounds, which occur in renal tubular cells, make the kidney more susceptible to injury (Halliwell & gutteridge, 1990). Teicoplanin (TEIC), a widely used antibiotic on the other hand has been demonstrated to induce nephrotoxicity in experimental animals and humans (Patel et al 2012, Sazanami et al 2021. However, Hesperetin (HESP) is said to possess antioxidant, anti-inflammatory, and nephroprotective effect among other biological activities (Parhiz et al 2015, Olayinka et al 2022.…”

Section: Discussionmentioning

confidence: 99%

“…Our data demonstrated that TEIC administration resulted in significant elevation of plasma levels of urea and creatinine. Increase urea and creatinine level in the blood has been linked to renal damage (Sazanami et al 2021). The pattern of elevation of these markers has been shown to be vital to the diagnosis of kidney injury.…”

Section: Discussionmentioning

confidence: 99%

“…Teicoplanin (TEIC) has been known to cause a number of toxicities such as nephrotoxicity, neurotoxicity amongst others and adverse effects in experimental animals and humans. Some of its reported toxicity in animal models and humans include; leucopenia, thrombocytopenia, eosinophilia, increase in transaminase, urea, creatinine and alkaline phosphatase (Patel et al 2012, Olssonn et al 2015, Sun et al 2020, Tai et al 2021, Sazanami et al 2021.…”

Section: Introductionmentioning

confidence: 99%

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Hesperetin attenuates teicoplanin-induced acute kidney injury by mitigating oxidative stress and inflammation in Wistar rats

Olayinka

Oni

Olajide

et al. 2022

Redox Experimental Medicine

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Objectives: Renal failure has been reported in patients treated with Teicoplanin, a widely used antibiotic. Hesperetin, a flavonoid in citrus fruits, has been reported to possess nephro-protective effects. This study investigated the protective effect of hesperetin on teicoplanin-induced nephrotoxicity in rats. Methods: Male wistar rats (n=32, 144-180 g) were grouped into 4 groups of 8 rats each. The control, group 1 received water, group 2 received 50 mg/kg of hesperetin orally, group 3 received 10 mg/kg of teicoplanin intraperitoneally and group 4 received 50 mg/kg of hesperetin and 10 mg/kg of teicoplanin. Administration was done for 21 days. Rats were sacrificed 24 hours after the last administration, the kidney was excised and used for biochemical assays. Results: Administration of teicoplanin resulted in kidney injury that was characterized by significant increase in plasma urea and creatinine level relative to control group (p<0.05). Additionally, significant increase in biomarkers of inflammation (NO, MPO, TNF-α) and lipid peroxidation (malondialdehyde) of teicoplanin-treated rats were observed when compared with the control group. Furthermore, altered antioxidants status was observed following teicoplanin treatment. Activities of enzymic antioxidants (SOD, CAT, GPx, GST) and concentration of non-enzymic antioxidants (GSH and Ascorbic acid) were downregulated. In comparison to the teicoplanin-treated group, the administration of Hesperetin with teicoplanin significantly reduced all changes in the markers of kidney injury, inflammation, and oxidative stress. Histopathological examination revealed that rats given TEIC showed increased glomerular size and considerable hydropic changes in the proximal convoluted tubules, whereas rats given HESP and TEIC showed only mildly enhanced glomerular size and hydropic modifications. Conclusion: Hesperetin preserved the histo-architecture of the kidney. From this study, hesperetin offered a protective effect against teicoplanin-induced nephrotoxicity in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hesperetin attenuates teicoplanin-induced acute kidney injury by mitigating oxidative stress and inflammation in Wistar rats

Olayinka

Oni

Olajide

et al. 2022

Redox Experimental Medicine

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“…Therefore, similar to the method applied in another study [14], we substituted it with the treatment and management fee for specific drugs, calculated once a month when TDM was conducted for the target drug. As the previous study described, nephrotoxic drugs were classified into the following groups: angiotensin II receptor blockers/angiotensin-converting enzyme inhibitors, diuretics, liposomal amphotericin B, nonsteroidal anti-inflammatory drugs, steroids, and piperacillin/tazobactam [15], and were extracted when administered on the same day as that of VCM. The site of infection was classified based on the indications related to the infection in the diagnostic information (S3 Table ).…”

Section: Definitions and Clinical Variablesmentioning

confidence: 99%

Influence of pharmacists and infection control teams or antimicrobial stewardship teams on the safety and efficacy of vancomycin: A Japanese administrative claims database study

Goto

Inose²,

Kusama³

et al. 2022

PLoS ONE

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Introduction Methicillin-resistant Staphylococcus aureus (MRSA) has a high mortality and requires effective treatment with anti-MRSA agents such as vancomycin (VCM). Management of the efficacy and safety of VCM has been implemented with the assignment of pharmacists in hospital wards and the establishment of teams related to infectious diseases. However, there are no reports evaluating the association between these factors and the efficacy and safety of VCM in large populations. Methods This study used the Japanese administrative claims database accumulated from 2010 to 2019. The population was divided into two groups, therapeutic drug monitoring (TDM) group and non-TDM group, and adjusted by propensity score matching. We performed multivariate logistic regression analysis to determine the influence of pharmacists and infection control teams or antimicrobial stewardship teams on acute kidney injury (AKI) and 30-day mortality. Results The total number of patients was 73 478 (TDM group, n = 55 269; non-TDM group, n = 18 209). After propensity score matching, 18 196 patients were matched in each group. Multivariate logistic regression analysis showed that pharmacological management for each patient contributed to the reduction of AKI (odds ratio [OR]: 0.812, 95% confidence interval [CI]: 0.723‒0.912) and 30-day mortality (OR: 0.538, 95% CI: 0.503‒0.575). However, the establishment of infectious disease associated team in facilities and the assignment of pharmacists in the hospital wards had no effect on AKI and 30-day mortality. In addition, TDM did not affect the reduction in AKI (OR: 1.061, 95% CI: 0.948‒1.187), but reduced 30-day mortality (OR: 0.873, 95% CI: 0.821‒0.929). Conclusion Pharmacologic management for individual patients, rather than assignment systems at facilities, is effective to reduce AKI and 30-day mortality with VCM administration.

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“…neutrophils-tolymphocyte), and medicines (e.g. antihypertensive, mannitol, and contrast 6,[9][10][11] ) could be efficient predictors for identifying ICH inpatients at risk of early AKI. [12][13][14] Based on these clinical features and laboratory tests, some models have been developed for the prediction of AKI in patients undergoing percutaneous coronary intervention, 15 pediatric critical care, 16 cirrhotic, 17 and organ transplantation.…”

Section: Introductionmentioning

confidence: 99%

Predictive model of acute kidney injury after spontaneous intracerebral hemorrhage: A multicenter retrospective study

Tian,

Zhang,

et al. 2023

European Stroke Journal

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Background and objectives: Acute kidney injury is a common comorbidity in patients with intracerebral hemorrhage. Although there are predictive models to determine risk of AKI in patients in critical care or post-surgical scenarios or in general medical floors, there are no models that specifically determine the risk of AKI in patients with ICH. Methods: Clinical features and laboratory tests were selected by previous studies and LASSO (least absolute shrinkage and selection operator) regression. We used multivariable logistic regression with a bidirectional stepwise method to construct ICH-AKIM (intracerebral hemorrhage–associated acute kidney injury model). The accuracy of ICH-AKIM was measured by the area under the receiver operating characteristic curve. The outcome was AKI development during hospitalization, defined as KDIGO (Kidney Disease: Improving Global Outcomes) Guidelines. Results: From four independent medical centers, a total of 9649 patients with ICH were available. Overall, five clinical features (sex, systolic blood pressure, diabetes, Glasgow coma scale, mannitol infusion) and four laboratory tests at admission (serum creatinine, albumin, uric acid, neutrophils-to-lymphocyte ratio) were predictive factors and were included in the ICH-AKIM construction. The AUC of ICH-AKIM in the derivation, internal validation, and three external validation cohorts were 0.815, 0.816, 0.776, 0.780, and 0.821, respectively. Compared to the univariate forecast and pre-existing AKI models, ICH-AKIM led to significant improvements in discrimination and reclassification for predicting the incidence of AKI in all cohorts. An online interface of ICH-AKIM is freely available for use. Conclusion: ICH-AKIM exhibited good discriminative capabilities for the prediction of AKI after ICH and outperforms existing predictive models.

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Incidence of acute kidney injury after teicoplanin– or vancomycin– and piperacillin/tazobactam combination therapy: A comparative study using propensity score matching analysis

Cited by 4 publications

References 21 publications

Hesperetin attenuates teicoplanin-induced acute kidney injury by mitigating oxidative stress and inflammation in Wistar rats

Hesperetin attenuates teicoplanin-induced acute kidney injury by mitigating oxidative stress and inflammation in Wistar rats

Influence of pharmacists and infection control teams or antimicrobial stewardship teams on the safety and efficacy of vancomycin: A Japanese administrative claims database study

Predictive model of acute kidney injury after spontaneous intracerebral hemorrhage: A multicenter retrospective study

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