Incidence of acute myocardial infarction resulting in sudden death outside the hospital

Adnet, Frédéric; Renault, Robin; Jabre, P.; Kulstad, Erik; Galinski, Michel; Lapostolle, Frédéric

doi:10.1136/emj.2010.095885

Cited by 12 publications

(10 citation statements)

References 22 publications

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“…Linkage across all data sources was used to improve case ascertainment because 25% to 50% of cardiovascular events are not recorded in at least 1 of the 3 sources. [14][15][16] The first cardiovascular event after the diagnosis of gout was used to ascertain case status as lifestyle changes after such an event may be associated with fewer subsequent gout flares. 17…”

Section: Nested Case-control Studymentioning

confidence: 99%

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout

Cipolletta

Tata

Nakafero

et al. 2022

JAMA

117

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Section: Nested Case-control Studymentioning

confidence: 99%

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout

Cipolletta

Tata

Nakafero

et al. 2022

JAMA

117

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“…The most common cause of sudden, unexpected, natural deaths in adults is arteriosclerotic cardiovascular disease, which accounts for as many as 34-55% of all such deaths (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness and Limitations of Triphenyltetrazolium Chloride to Detect Acute Myocardial Infarction at Forensic Autopsy

Kakimoto¹,

Tsuruyama²,

Miyao³

et al. 2013

American Journal of Forensic Medicine &Amp; Pathology

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Triphenyltetrazolium chloride (TTC) is one of the most conventional stains to detect infarcted area of the heart in animal experiments. However, its availability and limitations have not been thoroughly discussed in the forensic field. Here, authors stained human hearts with TTC soon after the harvest. Photographs of the samples were analyzed using image analysis software, which evaluated the occupying ratio of the stained area on the surface of each slice. The results showed that the stainability of TTC declines with the length of the postmortem interval (PMI). Specimens reacted well to TTC within 1.5 days after death and then decreased the stainability logarithmically with PMI (y = - 0.294 In (x) + 1.0441; x = PMI, y = TTC-stained area / total myocardial area, R = 0.5673). Samples with old myocardial infarction produced clear TTC contrast; normal tissue is vivid red, and fibrotic myocardium is white discoloration. In acute myocardial infarction cases where death occurred within 9 hours after the attack, however, the detection of infarcted area was very difficult even when PMI was less than 1.5 days. In summary, the TTC method may be useful within 1.5 days after death, but short suffering period before death disturbs its staining efficiency.

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“…This assumption is encouraged by the small proportion of present physicians (5–6%) and the high frequency of 36% among prehospital fatal cases with no witness for testifying the out-of-hospital deaths. A prospective study in France estimated that 35% out-of-hospital sudden deaths were due to acute MI 16 . The Finnish Genetic Study of Arrhythmic Events 17 found an even higher proportion of sudden deaths in relation to CHD.…”

Section: Discussionmentioning

confidence: 99%

Determinants of prehospital coronary heart disease death

Amann

Heier

Thilo³

et al. 2021

Sci Rep

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Limited data on prehospital and early in-hospital coronary heart disease (CHD) deaths is available. Aims of this study were to provide a comprehensive description on CHD cases and to analyse determinants of prehospital death. From a population-based myocardial infarction (MI) registry in Augsburg, Germany we included 12,572 CHD cases aged 25–74 years between 2003–2017 and 4754 CHD cases aged 75–84 years between 2009–2017. Multivariable logistic regression models were conducted to identify patient characteristics associated with prehospital death compared to 28-day survival. In patients aged 25–74 years, 1713 (13.6%) died prehospital, 941 (7.5%) died within the first 24 h in-hospital and 560 (4.5%) died within the 2nd and 28th day after the acute event; in patients aged 75–84 years the numbers were 1263 (26.6%), 749 (15.8%) and 329 (6.9%), respectively. In both age groups increasing age, actual smoking or nicotine abuse, previous MI, angina pectoris and previous stroke were more likely and hypertension was less likely in cases, who died prehospital compared to 28-day survivors. For example, in the 25–74 years old we revealed an adjusted odds ratio (OR) of 4.53 (95% CI 3.84–5.34) for angina pectoris and an OR of 0.69 (95% CI 0.57–0.85) for hypertension. In cases aged 25–74 years, an association of living alone (OR 1.26, 95% CI 1.06–1.49) and diabetes (OR 1.20, 95% CI 1.03–1.41) with prehospital death was found. Whereas in cases aged 75–84 years, chronic obstructive pulmonary disease (OR 2.20, 95%CI 1.69–0.2.85) was associated with prehospital death. In summary, we observed high prehospital and early in-hospital case fatality. Besides classical cardiac risk factors, the impact of living alone on prehospital death was more important in patients aged 25–74 years than in older patients.

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Incidence of acute myocardial infarction resulting in sudden death outside the hospital

Abstract: The estimated mortality of AMI appears to be 35% in this population. This figure suggests that significant improvement in the treatment of out-of-hospital cardiac arrest is still necessary.

Cited by 12 publications

References 22 publications

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout

The Effectiveness and Limitations of Triphenyltetrazolium Chloride to Detect Acute Myocardial Infarction at Forensic Autopsy

Determinants of prehospital coronary heart disease death

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