Incidence of advanced chronic renal failure and the need for end stage renal replacement treatment.

Feest, Terry; Mistry, Chandra D.; Grimes, Daniel T.; Mallick, N P

doi:10.1136/bmj.301.6757.897

Cited by 122 publications

(55 citation statements)

References 3 publications

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“…[18] However, we managed to overcome such difficulty by using the collaboration of our colleagues at the primary care level in our area and the referrals to our renal unit in a health program that is fully financed by the Kuwaiti government. Therefore, our observation of an incidence rate of 366 new patients with CRD PMY is higher than that reported in Europe, [11,12] but should be considered more realistic and alarming. Interestingly, the annual incidence rate of ESRD in our area is only 78 PMY, [1] indicating that only 21% are likely to progress to ESRD.…”

Section: Discussioncontrasting

confidence: 42%

Chronic Renal Disease in Kuwaiti Nationals: A Prospective Study During the Past 4 Years

El-Reshaid

Kapoor

et al. 2005

Renal Failure

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Section: Discussioncontrasting

confidence: 42%

Chronic Renal Disease in Kuwaiti Nationals: A Prospective Study During the Past 4 Years

El-Reshaid

Kapoor

et al. 2005

Renal Failure

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“…[11] Similarly, in Khan's study, the rate in the age group 50-69 was 159 pmp rising to 472 pmp in the 70-79 age group. [12] Today, BEN is detected usually in the sixth decade of life.…”

Section: Agementioning

confidence: 99%

Fifty Years of Balkan Endemic Nephropathy: Challenges of Study Using Epidemiological Method

et al. 2009

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Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial disease associated with urothelial cancer, which affects people living in the alluvial plains along the tributaries of the Danube River. Challenges of studying BEN using the epidemiological method are multiple. The natural history from exposure to occurrence of the disease may take many years. The early stages of BEN are not easily detectable clinically, as the disease is asymptomatic until a significant decline in function occurs, and even then symptoms are usually non-specific. The natural history of BEN is complex, possibly with multiple risk factors operating both at the stage of initiation of renal damage and in its progression. In BEN, genetic susceptibility is due to multiple genes of small effects, gene-gene interactions, and gene-environment interactions of complex nature that are difficult to assess with current study designs. BEN is now kidney disease of the old people, and many risk factors for disease such as smoking, alcohol consumption, obesity, and diabetes could contribute to the kidney damage. Evidence is presented that environmental rather than genetic factors play a decisive role in the etiopathogenesis of BEN. Aristolochic acid, described as a culprit of BEN in 1959, is confirmed in 2007 by the molecular biology methods. Mycotoxins and polycyclic aromatic hydrocarbons, leached from lignites and found in the vicinity of endemic settlements, deserve further investigation. Despite advances in understanding the epidemiology of BEN, more research is needed on the patterns of BEN over time and between places, and on identifying the contributions of modifiable risk factors in initiating and hastening progression of BEN in order to improve the scope for preventing BEN. Primary prevention is still at the beginning. Knowledge accumulated in the fifty years of BEN research and new data about prevention and treatment of chronic kidney disease reveal several effective methods in secondary and tertiary prevention of BEN. Genetic epidemiology could establish the relative size of the genetic effect in relation to other sources of variation in disease risk (i.e., environmental effects such as intrauterine environment, physical and chemical effects, as well as behavioral and social aspects). Public health authorities in the several countries having aristolochic acid nephropathy should take immediate measures for reducing dietary exposure of residents to Aristolochia.

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“…Two UK studies have estimated the annual incidence of ESRD based on creatinine concentrations of more than 500 µmol/l at 148 and 132 per million population (based on Feest, 1990, in Devon and the North-West, quoted by the Renal Association, 10 and Khan, 1994, based in Grampian, 15 respectively). Figures based on the Renal Registry in England suggest that 104 people per million population start renal replacement therapy (RRT) each year (about 6000 people), of whom 3% will receive a kidney transplant within 90 days, while the remainder receive dialysis.…”

Section: Epidemiology Of Ckd and Esrdmentioning

confidence: 99%

The effectiveness and cost-effectiveness of cinacalcet for secondary hyperparathyroidism in end-stage renal disease patients on dialysis: a systematic review and economic evaluation

Garside¹,

Pitt²,

Anderson³

et al. 2007

Health Technol Assess

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Incidence of advanced chronic renal failure and the need for end stage renal replacement treatment.

Cited by 122 publications

References 3 publications

Chronic Renal Disease in Kuwaiti Nationals: A Prospective Study During the Past 4 Years

Chronic Renal Disease in Kuwaiti Nationals: A Prospective Study During the Past 4 Years

Fifty Years of Balkan Endemic Nephropathy: Challenges of Study Using Epidemiological Method

The effectiveness and cost-effectiveness of cinacalcet for secondary hyperparathyroidism in end-stage renal disease patients on dialysis: a systematic review and economic evaluation

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