Incidence of Adverse Events Among Healthcare Workers Following H1N1 Mass Immunization in Ghana

Ankrah, Daniel; Mantel‐Teeuwisse, Aukje K.; Bruin, Marie L. De; Amoo, Philip K; Ofei-Palm, Charles; Agyepong, Irène Akua; Leufkens, Hubert G. M.

doi:10.1007/s40264-013-0037-7

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Similar observations have been described with other vaccines. [7][8][9][10] The other signs and symptoms reported in this study were found to be similar to those described elsewhere with other vaccines. [8][9][10] No case of AEFI associated with OPV in adult population and in the pediatric population could be found with the use of available computer-assisted medical literature search programs.…”

Section: Discussionsupporting

confidence: 83%

“…[7][8][9][10] The other signs and symptoms reported in this study were found to be similar to those described elsewhere with other vaccines. [8][9][10] No case of AEFI associated with OPV in adult population and in the pediatric population could be found with the use of available computer-assisted medical literature search programs. However, according to a WHO document entitled 'supplementary information on vaccine safety, background rates of adverse events following immunization', 11 common minor vaccine reaction associated with OPV are fever, irritability, malaise, and non-specific symptoms, such as diarrhea, headache, and/or muscle pain.…”

Section: Discussionsupporting

confidence: 82%

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Adverse events following immunization with oral poliovirus in Kinshasa, Democratic Republic of Congo: preliminary results

Nzolo

Aloni

Ngamasata

et al. 2013

Pathogens and Global Health

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Aim:We investigated the nature and frequency of adverse events following immunization (AEFI) associated with oral polio vaccines (OPV) in the general population in Kinshasa, Democratic Republic of Congo (DR Congo). Methods: The DR Congo National Pharmacovigilance Centre organized active AEFI surveillance during mass immunization campaigns for the general population from March to June 2011. A patient individual case safety report was used as a questionnaire and addressed to pupils and students from high schools and universities who had any adverse events after OPV administration. We used the preferred term from the WHO Adverse Reaction Terminology for AEFI designation. Here is presented the results of the second step of the mass immunization campaign. Results: A total of 767 patients reported AEFI during the second step. Sex distribution shows that 512 (66.8%) students were females, while 255 (33.2%) were males, giving a female/male ratio 2 : 1. The average age was 16.865.19 years (ranged: 6-35.5 years). Each person reported a mean of 1.3360.6 AEFI. The average AEFI onset duration was 1.7461.16 days post-vaccination, ranging from 1 to 9 days. Headache (22.4%), abdominal pain (17.2%), fever (11.7%), diarrhea (9.9%), and asthenia (7.5%) were the common symptoms. Paralysis and asthma-like reactions were rare and serious adverse events in this study. The most affected systems were gastro-intestinal (33.5%) and nervous system (29.3%). Rechallenge was positive for 173 persons (22.6%). Conclusion: OPV-related AEFIs are not uncommon, although it is under-reported. Active AEFI surveillance during mass immunization campaigns is very important and may help to detect rare and serious adverse events. Further investigation will be important to identify risk of AEFI with OPV in adults and is warranted to elucidate the cause of this association in the Congolese environment.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 82%

Adverse events following immunization with oral poliovirus in Kinshasa, Democratic Republic of Congo: preliminary results

Nzolo

Aloni

Ngamasata

et al. 2013

Pathogens and Global Health

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“…4,7,8 Smartphone penetration in Australia was reported at 65% in 2013, making it a suitable market for the use of such technology. 8 In the same survey, smartphone use is reportedly less common in other countries such as the United Kingdom (62%) and the United States (56%), however overall there is increasing smartphone penetration globally, and in future the use of this technology has applications any time a new vaccine is introduced.…”

Section: Resultsmentioning

confidence: 99%

Adverse Events Following Influenza Immunization Reported by Healthcare Personnel Using Active Surveillance Based on Text Messages

Tracey

Regan

Mak

et al. 2015

Infect. Control Hosp. Epidemiol.

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“…There was one study on Haemophilus influenza type b vaccine 28 , two studies on influenza A (H1N1) vaccine 29,30 , one study on measles-rubella vaccine 31 , one study on meningococcal vaccine 32 , one study on oral polio vaccine 33 , two studies on pneumococcal vaccine 34,35 , one study on rotavirus vaccine 36 , two BCG vaccine studies 37,38 and one yellow fever vaccine study 39 . With the exception of only one study which assessed two vaccines (Measles-Rubella) in one formulation 31 , all the remaining studies assessed vaccines containing only one active ingredient.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…West, East, Central, North and Southern Africa were represented. The West African countries were Ghana 29,36 , Togo 39 , Benin 39 , Mali 32,36,39 , Senegal 32,39 , Liberia 39 , Guinea 39 , Sierra Leone 39 and Gambia 32,34 . The east African country was Kenya 39 .…”

Section: Identificationmentioning

confidence: 99%

A review of the safety of vaccines used in routine immunization in Africa

Yamoah¹,

Bangalee²,

Oosthuizen³

2020

Afr H. Sci.

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Background: Despite the significant role played by vaccines in global health, concerns over vaccine safety have increased tre- mendously over the years. There have been occasions where vaccines have caused rare, adverse reactions some of which have led to hospitalizations and even death. It is therefore important to establish the safety profile of routinely used vaccines in order to allay fears pertaining to their use. Objectives: This review was aimed at pooling together the safety data of selected vaccines used for routine immunization in Africa, a region of the world with paucity of vaccine safety data. Methods: Adverse Events Following Immunization safety data was searched for rotavirus, yellow fever, measles, rubella, tuber- culosis (Bacillus Calmette Guerin-BCG), pneumococcal, Haemophilus Influenza type b, polio, meningococcal and the influenza A (H1N1) vaccines in PUBMED, Google Scholar, Clinical trials.gov and Cochrane controlled register of trials databases. Results: A total of twenty-four serious AEFIs and twenty-three minor AEFIs were identified from the review. The strength of association between AEFIs and vaccine was high for tuberculosis vaccine and moderate for all other vaccines. Conclusion: Even though AEFIs (including mild and severe) were identified in the review, all the vaccines studied were gener- ally well tolerated. Keywords: Safety of vaccines; immunization; Africa.

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Incidence of Adverse Events Among Healthcare Workers Following H1N1 Mass Immunization in Ghana

Cited by 7 publications

References 29 publications

Adverse events following immunization with oral poliovirus in Kinshasa, Democratic Republic of Congo: preliminary results

Adverse events following immunization with oral poliovirus in Kinshasa, Democratic Republic of Congo: preliminary results

Adverse Events Following Influenza Immunization Reported by Healthcare Personnel Using Active Surveillance Based on Text Messages

A review of the safety of vaccines used in routine immunization in Africa

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