Incidence of Alzheimer’s Disease and Other Dementias: Results from the 2017 Global Burden of Disease Study

Guo, Xin-Heng; He, Hairong; Qü, Yan; Liu, Jie; Qu, Qiumin; Lyu, Jun

doi:10.21203/rs.3.rs-43686/v1

Cited by 2 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the traditional societies that have incorporated the so-called western lifestyle (which includes taking pills) are the ones that have increased the incidence of AD the fastest [103,104].…”

Section: Distribution Of Patients With Ad In Different Populationsmentioning

confidence: 99%

Can chronic therapeutic drug use by the elderly affect Alzheimer’s disease risk and rate of progression?

Franco

Serrano-Marín

2023

Explor Neuroprot Ther

View full text Add to dashboard Cite

There is no approved drug capable of halting the progression of the most prevalent neurodegenerative disorders, namely Alzheimer’s disease (AD) and Parkinson’s disease (PD). Current therapeutic strategies focus mainly on the inhibition of the formation of protein aggregates and their deposition in the central nervous system. However, after almost a hundred years, proper management of the disease is still lacking. The fact of not finding effective management tools in the various clinical trials already carried out suggests that new hypotheses and strategies should be explored. Although vast resources have been allocated to the investigation of protein aggregates and the pathophysiology is now better understood, clues to the actual etiology are lacking. It is well known that brain homeostasis is of paramount importance for the survival of neurons. Drugs that target the periphery are often not subject to evaluation for their potential effect on the central nervous system. While acute treatments may be irrelevant, pills used for chronic conditions can be detrimental to neurons, especially in terms of progressive damage leading to a long-term decline in neuronal survival. Due to the lack of advances in the search for a curative treatment for neurodegenerative diseases, and the lack of new hypotheses about their etiology, a novel hypothesis is here proposed. It consists of assuming that the effects of the drugs most commonly used by the elderly, such as antihypertensive, hypoglycemic, and hypocholesterolemic, could have a negative impact on neuronal survival.

show abstract

Section: Distribution Of Patients With Ad In Different Populationsmentioning

confidence: 99%

Can chronic therapeutic drug use by the elderly affect Alzheimer’s disease risk and rate of progression?

Franco

Serrano-Marín

2023

Explor Neuroprot Ther

View full text Add to dashboard Cite

show abstract

“…The 11 to 12% people of first world countries or high-income countries are suffering with the nerve cells degenerative disease. 6 In Pakistan about 219 people per 100,000 individuals are suffering from Parkinson's disease and the trend is rising. The contributing factors are gender and age, depressive illnesses, exposure to drugs like pesticides, smoke, occupation, sedentary life style like consuming health deleterious diets, consuming alcohol etc.…”

mentioning

confidence: 99%

Study of Treatment Pattern of Neurodegenerative Diseases in a Pakistani Context

Alina Atif

2022

j Muhammad Med Coll

View full text Add to dashboard Cite

Introduction: Neurodegenerative disease is a multi-factorial disease which isattributed to the constant degeneration of the function and structure of central andperipheral nervous system. Alzheimer and Parkinson’s diseases are common degenerative diseases all over the world including Pakistan.Objectives: To find out the disease treatment pattern of neurodegenerative diseases (Alzheimer's disease and Parkinson’s disease) in a Pakistani context. The studywill help the practicing neuro physicians in Pakistan to get an insight about the findings.Methodology: This study was conducted at private hospital of Karachi having 200indoor patients from Dec 2020 to June 2021. Patients selected through conveniencesampling by screening at two stages. At first the patients were screened at generalOPD or ER. The attending physician then referred the cases to consultant physicians.After confirmation at this level the cases referred to the neurologist. A total of 146patients were diagnosed for Alzheimer disease while 46 were diagnosed for Parkinson’s disease.Results: For this cohort 146 cases diagnosed as having Alzheimer's disease; femaleoutnumber male and almost all were suffering from one or more other illness aswell. Mild grade seen mostly during 50-59 years of age. 48 cases were diagnosed asParkinson's disease, males affected more than female and most were in their fifties.In comparison to Alzheimer's disease, Parkinson’s disease had a mild relationshipwith the independent variables for example motor symptoms and other comorbidity. Keywords: Neurogenerative disorders, Parkinsonism, Alzheimer disease.

show abstract

Incidence of Alzheimer’s Disease and Other Dementias: Results from the 2017 Global Burden of Disease Study

Cited by 2 publications

References 27 publications

Can chronic therapeutic drug use by the elderly affect Alzheimer’s disease risk and rate of progression?

Can chronic therapeutic drug use by the elderly affect Alzheimer’s disease risk and rate of progression?

Study of Treatment Pattern of Neurodegenerative Diseases in a Pakistani Context

Contact Info

Product

Resources

About