Incidence of an Aberrant Right Subclavian Artery on Second-Trimester Sonography in an Unselected Population

Erzincan, Selen Gürsoy; Balcı, Burçin Karamustafaoğlu; Tokgoz, Cengiz; Kalelioğlu, I.

doi:10.7863/ultra.16.05075

Cited by 16 publications

(20 citation statements)

References 13 publications

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“…Reported by Ranzini et al [12], all fetuses with ARSA and genetic anomalies totally had additional ultrasound findings. Thus, in similar studies ( respectively published in Fetal Diagn Ther and J Ultrasound Med) [5,6], the authors typically included fetuses have consistently classified fetuses with negative prenatal screening and postpartum follow-up as normal karyotypes. Therefore, we believe that the method adopted in this study is acceptable.…”

Section: Discussionmentioning

confidence: 99%

“…Prevalence of ARSA was 1.02 % in euploid fetuses, whereas 23.6 % in Down's syndrome fetuses [8]. Therefore, ARSA appears to be a fairly reliable ultrasound clue for fetal chromosomal abnormalities, especially congenital cardiac defects and aneuploid abnormality [5][6][7][8].…”

Section: Introductionmentioning

confidence: 95%

“…During pregnancy, ARSA may easily be detected by prenatal ultrasonography whatever the trimester of pregnanc [5]. The incidence rate of ARSA as an isolated abnormality in healthy populations is known to be about 1 % to 2 % [6]. Even so, Chaoui et al [7].…”

Section: Introductionmentioning

confidence: 99%

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Predictive value of aberrant right subclavian artery for fetal chromosomal in women of advanced maternal age

You

Chen

Zhong

et al. 2019

Preprint

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Background: In entire population, aberrant right subclavian artery ( ARSA ) was in closely association with chromosomal abnormalities. The risk of fetal chromosomal abnormalities increased with the maternal age exponentially. While, the situation in advanced maternal age ( AMA ) group is uncertain. This study aimed to establish the incidence of ARSA in Chinese AMA and non-AMA women and to determine the frequency of aneuploidy among AMA and non-AMA women with ARSA. Methods: The retrospective study included 13,690 singleton pregnancies which were divided into AMA and non-AMA groups. Integrated obstetric ultrasonic screening, biochemical screening, noninvasive prenatal screening and fetal karyotype analysis were analyzed. Results: 1. The overall incidence of ARSA was 0.69 % with no difference in both groups. 2. The prevalence rate of chromosomal abnormalities in AMA group ( 37 / 2,860 ) was much higher than that in non-AMA group. The risk of chromosomal abnormalities significantly increased with both ARSA detected and additional ultrasound findings. 3. With ARSA detected, the incidence increased to 20.00 % and 10.00 % in AMA and non-AMA cases, respectively. 4. Additionally, a case with chimeric Turner syndrome ( 45X / 46XX ) was found with isolated ARSA in AMA pregnancy. Conclusion: There is a high prevalence of chromosomal abnormalities in AMA fetuses. Both isolated and nonisolated ARSA would increase the risk of chromosomal abnormalities. Moreover, when ARSA is found in AMA ones, it confers a sharp increase in the incidence of chromosomal abnormalities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Predictive value of aberrant right subclavian artery for fetal chromosomal in women of advanced maternal age

You

Chen

Zhong

et al. 2019

Preprint

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“…Prevalence of ARSA was 1.02% in euploid fetuses, whereas 23.6% in Down's syndrome fetuses [10]. Therefore, ARSA appears to be a fairly reliable ultrasound clue for fetal chromosomal abnormalities, especially congenital cardiac defects and aneuploid abnormality [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 96%

“…During pregnancy, ARSA may easily be detected by experienced / trained ultrasound operators during prenatal ultrasonography whatever the trimester of pregnancy [6]. The incidence rate of ARSA as an isolated abnormality in healthy populations is known to be about 1 % to 2 % [7]. Even so, Chaoui et al [8,9].…”

Section: Introductionmentioning

confidence: 99%

Predictive value of aberrant right subclavian artery for fetal Chromosome aneuploidy in women of advanced maternal age

Chen

Zhong

You

et al. 2020

Preprint

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Background: In entire population, aberrant right subclavian artery ( ARSA) was in closely association with chromosomal abnormalities. The risk of fetal chromosomal abnormalities increased with the maternal age exponentially. This situation in advanced maternal age ( AMA )group is uncertain. This study aimed to establish the incidence of ARSA in Chinese AMA and non-AMA women and to determine the frequency of aneuploidy among AMA and non-AMA women with ARSA.Methods: The retrospective study included 13,690 singleton pregnancies which were divided into AMA and non-AMA groups. Integrated obstetric ultrasonic screening, biochemical screening, noninvasive prenatal screening and fetal karyotype analysis were analyzed.Results: 1. The overall incidence of ARSA was 0.69 % with no difference in both age groups. 2. The incidence rate of chromosomal abnormalities in AMA group ( 37 / 2,860 ) was much higher than that in non-AMA group. The risk of chromosomal abnormalities significantly increased with both ARSA detected and additional ultrasound findings. 3. With combined ARSA detected in AMA ones, the lilelihood of the incidence of chromosomal abnormalities increased. 4. Additionally, a case with chimeric ( 45X / 46XX ) was found with isolated ARSA in AMA pregnancy.Conclusion: There is a high prevalence of chromosomal abnormalities in AMA fetuses. ARSA would increase the risk of chromosomal abnormalities in both age groups, especially combined ARSA. Moreover, when combined ARSA is found in AMA ones, it confers a high likelihood of chromosomal abnormalities.

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Microarray analysis has no additional value in fetal aberrant right subclavian artery: description of 268 pregnancies and systematic literature review

Sagi‐Dain

Singer

Josefsberg

et al. 2019

Ultrasound in Obstet & Gyne

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Objectives Fetal aberrant right subclavian artery (ARSA) is a relatively common sonographic finding. Several studies have reported a significant association between ARSA and Down syndrome, as well as 22q11.2 microdeletion. The objective of this study was to assess the risk of abnormal chromosomal microarray analysis (CMA) findings in a large cohort of pregnancies with fetal ARSA as an isolated, as well as a non-isolated, sonographic anomaly. A secondary objective was to review the literature, examining the frequency of chromosomal microarray aberrations in fetuses with isolated ARSA.Methods Data from all pregnancies referred for invasive testing and CMA due to sonographic diagnosis of fetal ARSA, between 2013 and 2017, were obtained retrospectively from the computerized database of the Israeli Ministry of Health. The rate of clinically significant CMA findings in these fetuses was compared to that in a local control population of 2752 low-risk pregnancies with normal ultrasound and serum screening results. In addition, a literature search was conducted in PubMed, from inception to February 2018, of original studies in the English language describing the frequency and nature of microscopic and submicroscopic aberrations in fetuses with isolated ARSA. ResultsOf 246 pregnancies with isolated ARSA that underwent CMA analysis, a clinically significant finding was detected in one (0.4%) pregnancy (trisomy 21). This rate did not differ significantly from that in the control population (P = 0.1574). Of 22 fetuses with non-isolated ARSA, one (4.5%) additional case of trisomy 21 was noted. The frequency of trisomy 21 in this cohort also did not differ from that in the control population (relative risk, 5.5 (95% CI,). The literature search yielded 13 additional relevant papers, encompassing 333 cases of isolated ARSA. Of 579 cases overall (including those of the present study), 13 (2.2%) cases of trisomy 21 were detected, with no cases of 22q11.2 microdeletion. ConclusionWhile an association may exist between non-isolated ARSA and Down syndrome, isolated ARSA might better serve as a soft marker for Down syndrome, rather than a routine indication for invasive prenatal testing.

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Incidence of an Aberrant Right Subclavian Artery on Second-Trimester Sonography in an Unselected Population

Abstract: In an unselected population, an ARSA may be seen less frequently than in a high-risk population and may not be related to Down syndrome. An isolated ARSA is not a sufficient indication for karyotype analysis; it can be managed with noninvasive prenatal testing rather than invasive testing.

Cited by 16 publications

References 13 publications

Predictive value of aberrant right subclavian artery for fetal chromosomal in women of advanced maternal age

Predictive value of aberrant right subclavian artery for fetal chromosomal in women of advanced maternal age

Predictive value of aberrant right subclavian artery for fetal Chromosome aneuploidy in women of advanced maternal age

Microarray analysis has no additional value in fetal aberrant right subclavian artery: description of 268 pregnancies and systematic literature review

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