Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients

Liang, Hao; Zeng, Xiang-Peng; Xin, Lei; Wang, Dan; Pan, Jun; Bi, Yang; Ji, Jun-Tao; Du, Tingting; Lin, Jin‐Huan; Zhang, Di; Ye, Bo; Zou, Wenbin; Chen, Hui; Xie, Ting; Li, Bai-Rong; Zhang, Zheng; Wang, Teng; Guo, Hong-Lei; Liao, Zhuan; Li, Zhao‐Shen; Hu, Liang‐Hao

doi:10.1016/j.dld.2017.07.001

Cited by 85 publications

(59 citation statements)

References 46 publications

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“…Earlier studies agree on cancer being the main cause of death . Pancreatic cancer was reported markedly increased in CP patients, but it was not detected in the present study. Digestive diseases were also reported the main cause of death in CP patients, but they were not found in the present study.…”

Section: Discussioncontrasting

confidence: 50%

“…This may be attributed to the alleviation of aging in developing countries in the past years. However, 13.2% of the CP patients in China were 65 years or older, which indicates that developing countries will also face the problem of aging in the next few years. Frequency of pancreatic duct stones were found increased depending on the age of the patients .…”

Section: Introductionmentioning

confidence: 99%

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Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis

Liang

Liu

Wang

et al. 2019

J of Gastro and Hepatol

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Background and Aim Pancreatic extracorporeal shock wave lithotripsy (P‐ESWL) is a first‐line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P‐EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P‐ESWL for them. Methods This prospective study was conducted in painful CP patients who underwent P‐ESWL. Patients aged over 65 years were included in geriatric group; patients aged under 65 years were assigned to control group. For the long‐term follow‐up investigation, geriatric patients were matched with patients from the control group in a 1:1 ratio. Primary outcomes were complications of P‐ESWL and pain relief. Secondary outcomes included stone clearance, physical and mental health, quality of life score, changes in exocrine and endocrine pancreatic function, and survival. Results From March 2011 to March 2016, P‐ESWL was performed in 1404 patients (72 in the geriatric group and 1332 in the control group). No significant differences were observed in complications of P‐ESWL between the two groups (P = 0.364). Among the 67 (67/72, 93.1%) geriatric patients who underwent follow up for 4.02 years, complete pain relief was achieved in 53 patients, which was not significantly different from that of matched controls (54/70; P = 0.920). The death in the geriatrics was significantly higher (P = 0.007), but none of them were correlated with P‐ESWL. Conclusions P‐ESWL is safe and effective for geriatric CP patients with pancreatic stones. It can promote significant pain relief and stone clearance and improve quality of life and mental and physical health.

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Section: Discussioncontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis

Liang

Liu

Wang

et al. 2019

J of Gastro and Hepatol

Self Cite

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show abstract

“…Contrary to this finding, another study of 1,656 chronic pancreatitis patients reported that both endoscopic and surgical treatment was associated with a higher risk of pancreatic cancer compared to no treatment. 3 However, estimates from this study were equally imprecise as in the study by Ueda et al Accordingly, we find it questionable that surgery should reduce pancreatic cancer risk in chronic pancreatitis. Even if this is the case, we consider it unlikely that surgery would be associated with the exposure (statin prescriptions).…”

contrasting

confidence: 67%

Author's Reply to: “Design flaws in statins and pancreatic cancer research” (IJC‐19‐0941)

Kirkegård

Lund

Mortensen

et al. 2019

Intl Journal of Cancer

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“…From our point of view, patients with suspected pancreatic cancer should be excluded from the current study, and a period of 1 year is insufficient for excluding patients with misdiagnosed pancreatic cancer. 2 In almost all CP research, particularly involving CP and pancreatic cancer, patients diagnosed with pancreatic cancer within 2 years of follow-up were excluded and some studies even used another 5 years to mitigate misdiagnoses further. [3][4][5] Second, the main treatments for CP include endoscopic therapy and surgery.…”

mentioning

confidence: 99%

Design flaws in statins and pancreatic cancer research

Liu

Wang

et al. 2019

Intl Journal of Cancer

Self Cite

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Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients

Cited by 85 publications

References 46 publications

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis

Author's Reply to: “Design flaws in statins and pancreatic cancer research” (IJC‐19‐0941)

Design flaws in statins and pancreatic cancer research

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