Incidence of Antibiotic-Resistant Staphylococci in a Hospital

Rountree, PhyllisM.; Thomson, E. F.

doi:10.1016/s0140-6736(52)92380-5

Cited by 53 publications

(5 citation statements)

References 6 publications

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“…Strains sensitive to penicillin were very rarely resistant to any other antibiotic. As expected, most of those resistant to one or more antibiotic in addition to penicillin were members of phage-group III (Rountree & Thompson, 1952;Barber & Burston, 1955), and all except three of the ninety 'multipleresistant' group III strains were from infections acquired in hospital. There was some evidence that resistance to several antibiotics was less common among strains from new-born infants than from older hospital patients.…”

Section: Resistance To Other Antibioticssupporting

confidence: 72%

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Parker

1958

J. Hyg.

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1. A collection of 1389 strains ofStaphylococcus aureusof human origin was examined by the following tests: phage typing, antibiotic resistance, ability to inhibit the growth ofCorynebacterium diphtheriae, the egg-yolk reaction and the serum opacity reaction.2. Nearly all strains ofStaph. aureusType 71 were penicillin resistant, inhibitedC. diphtheriae, gave a negative egg-yolk reaction, and produced a zone of opacity on horse-serum agar.3. The penicillin resistance of Type 71 strains is unlikely to have arisen as a result of the therapeutic use of penicillin, and is probably a natural characteristic of the type.4.Staph. aureusstrains which gave a negative egg-yolk reaction and a positive serum opacity reaction occurred almost exclusively in superficial lesions. The majority of them were members of Type 71, or were penicillin-resistant members of phage-group III. It is suggested that these organisms can cause superficial inflammation, but are usually unable to invade deeper tissues.I wish to thank Dr A. J. H. Tomlinson for valuable information about his unpublished work on impetigo. Thanks are also due to many colleagues who have provided cultures and clinical information, to Dr R. E. O. Williams for typing phages, and to Mr L. E. Simmons for technical assistance.

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Section: Resistance To Other Antibioticssupporting

confidence: 72%

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Parker

1958

J. Hyg.

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“…Many reports (Rountree & Thomson, 1952;Clarke, Dalgleish & Gillespie, 1952;Lowbury, Topley & Hood, 1952;Shooter et al 1958;Williams, 1959;and Barber et al 1960) have emphazised the dangerous nature of tetracycline resistant strains, their emergence and predominance in cases of hospital sepsis, and their ability to spread by cross-infection.…”

Section: Resultsmentioning

confidence: 99%

Mercury resistance and tetracycline resistance inStaphylococcus aureus

1967

J. Hyg.

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Minimum inhibitory concentrations of tetracycline to 256 tetracycline-resistant strains ofStaphylococcus aureuswere determined. M.I.C.'s tetracycline were appreciably higher among mercury resistant than among mercury sensitive strains.Mercury resistant strains representing various M.I.C.'s tetracycline grew significantly better in peptone water containing a therapeutic concentration of tetracycline than mercury sensitive strains representing the same range of resistance. The experiment was repeated after both groups had been adapted—or ‘trained’—to grow on agar containing tetracycline, 100µg./ml. The mercury sensitive strains now grew better than the mercury resistant group.The significance of these findings is discussed. It is concluded that tetracycline resistance is more stable and efficient in mercury resistant strains, and that it is probably genetic in origin—the result of mutation and selection. Tetracycline resistance in mercury sensitive strains is possibly the result of ‘training’.The associations and significance of both mercury resistance and tetracycline resistance inStaphylococcus aureusare discussed.

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“…These results inay explain the often reported observation that the streptomycin-resistant S t a p h . aureus strains isolated from clinical specimens practically always are also resistant to penicillin ( 9 ) . The acquired resistance to streptomycin was not followed by any considerable changes of the bacteria in contrast to what was observed with penicillin.…”

Section: Discussionmentioning

confidence: 99%

In‐vitro Induced Resistance to Penicillin, Streptomycin, and Aureomycin in Penicillin‐sensitive and in Penicillinase Producing Staphylococcus Aureus Pyogenes

Wallmark¹

1954

Acta Pathologica Microbiologica Scandinavica

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Incidence of Antibiotic-Resistant Staphylococci in a Hospital

Cited by 53 publications

References 6 publications

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Mercury resistance and tetracycline resistance inStaphylococcus aureus

In‐vitro Induced Resistance to Penicillin, Streptomycin, and Aureomycin in Penicillin‐sensitive and in Penicillinase Producing Staphylococcus Aureus Pyogenes

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