Incidence of antibodies to native and denatured cartilage collagens (types II, IX, and XI) and to type I collagen in rheumatoid arthritis.

Morgan, K; Clague, R B; Collins, Ian; Ayad, Shirley; Phinn, Shirley D; Holt, P. J.

doi:10.1136/ard.46.12.902

Cited by 70 publications

(42 citation statements)

References 16 publications

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“…The assay confirmed the presence of IgGs principally against the monomeric form of collagen type II and similar, but weaker signal, against collagen type I. Involvement of collagen type II in the autoimmune reaction is highly probable; IVD degeneration has been correlated with increased degradation of collagen II (Antoniou et al, 1996), yet collagen II might trigger articular cartilage diseases (Burkhardt et al, 2002) and antibodies to denatured collagens have been found in patients with rheumatoid arthritis (RA) (Morgan et al, 1987). We also found antibodies against the minor fibrillar human collagen type V, which plays a role in the organisation of heterotypic type I/V collagen fibrils (Birk, 2001).…”

Section: S Capossela Et Almentioning

confidence: 76%

Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins

Capossela

Schläfli²,

Bertolo³

et al. 2014

eCM

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Degeneration of intervertebral discs (IVDs) is associated with back pain and elevated levels of inflammatory cells. It has been hypothesised that discogenic pain is a direct result of vascular and neural ingrowth along annulus fissures, which may expose the avascular nucleus pulposus (NP) to the systemic circulation and induce an autoimmune reaction. In this study, we confirmed our previous observation of antibodies in human degenerated and posttraumatic IVDs cultured in vitro. We hypothesised that the presence of antibodies was due to an autoimmune reaction against specific proteins of the disc. Furthermore we identified antigens which possibly trigger an autoimmune response in degenerative disc diseases. We demonstrated that degenerated and post-traumatic IVDs contain IgG antibodies against typical extracellular proteins of the disc, particularly proteins of the NP. We identified IgGs against collagen type II and aggrecan, confirming an autoimmune reaction against the normally immune privileged NP. We also found specific IgGs against collagens types I and V, but not against collagen type III. In conclusion, this study confirmed the association between disc degeneration and autoimmunity, and may open the avenue for future studies on developing prognostic, diagnostic and therapymonitoring markers for degenerative disc diseases.

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Section: S Capossela Et Almentioning

confidence: 76%

Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins

Capossela

Schläfli²,

Bertolo³

et al. 2014

eCM

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“…cence (2,3), and ELISA (7,25), have demonstrated that antibodies that react with various types and sources of collagen are present in serum and synovial fluid of RA patients. Despite these findings, there is controversy regarding the incidence and specificity of anticollagen antibodies found in RA patients.…”

Section: Resultsmentioning

confidence: 99%

Specificity of antibodies to type II collagen in rheumatoid arthritis

Terato

Shimozuru

Katayama

et al. 1990

Arthritis & Rheumatism

170

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To reassess the role of autoantibodies to type II collagen in the pathogenesis of diseases, we studied antibodies from patients with rheumatoid arthritis (RA) and from patients with relapsing polychondritis for species specificity and collagen type specificity, using an improved enzyme‐linked immunosorbent assay. Antibodies were found in the sera of 15% of the RA patients and 50% of the relapsing polychondritis patients, as well as in the cartilage of 69% of the RA patients examined. Reaction with both homologous and heterologous type II collagens was common. Analysis of 19 selected RA sera revealed that autoantibodies were generally associated with specific antibodies to some species of heterologous type II collagen. In contrast, antibodies found in 4% of the non‐RA controls were specific for either bovine or chick type II collagen. These findings indicate that autoantibody formation in RA and relapsing polychondritis may occur as a result of an immune response to heterologous type II collagen. However, since RA and relapsing polychondritis patient sera differed in their reactivity with the cyanogen bromide‐digested peptides, it is possible that the clinical manifestation of collagen autoimmunity might be influenced by the epitope specificity of the antibodies.

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“…Several recently established mice bearing loss-of-function mutations in other widely and/or highly expressed genes such as tenascin (23), c-src (24), and nerve growth factor receptor (25) in human articular cartilage with age (27), and it is tempting to speculate that this decrease may be associated with the higher incidence ofOA in the elderly. In rheumatoid arthritis, autoantibodies reacting with type II and with type IX collagen molecules have been demonstrated (29,30); it is conceivable that these autoantibodies may interfere with type IX collagen function in addition to that of type II collagen and thus contribute to the disease process.…”

Section: Discussionmentioning

confidence: 99%

Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.

Fässler

Schnegelsberg

Dausman

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

267

181

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Incidence of antibodies to native and denatured cartilage collagens (types II, IX, and XI) and to type I collagen in rheumatoid arthritis.

Cited by 70 publications

References 16 publications

Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins

Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins

Specificity of antibodies to type II collagen in rheumatoid arthritis

Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.

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