Incidence of antiemetic‐induced akathisia in patients at a comprehensive cancer center

Rashid, A.; Olubajo, T.; Garza, Richard De La

doi:10.1002/pon.4597

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Rashid et al reported a 4.7% incidence of akathisia among patients taking antiemetic agents in a retrospective study in a tertiary cancer center. 20 A 2016 systematic review of antipsychotic-induced akathisia stated that a lack of studies with specific scales for evaluation, and patients with cancer and terminally ill patients in palliative care settings could be at higher risk for the development of akathisia as a side effect. 21 The objective of these above-mentioned studies was mainly akathisia, which was not diagnosed using a validated tool.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Extrapyramidal Symptoms in Cancer Patients Referred to Palliative Care: A Multicenter Observational Study (JORTC PAL12)

Ishiki

Hamano

Nagaoka

et al. 2020

Am J Hosp Palliat Care

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Background: Neuroleptics are commonly used in palliative care settings. However, adverse events of neuroleptics, known as extrapyramidal symptoms (EPSs), might be overlooked in clinical practice. We conducted this study to explore the prevalence of EPSs in palliative care setting. Methods: This multicenter, prospective, observational study included patients who 1) were referred to either a specialist palliative care team or a palliative care unit, 2) had a diagnosis of cancer, and 3) were ≥20 years of age. We investigated the prevalence of EPSs and medications used. The primary outcome was the overall Drug-Induced Extrapyramidal Symptom Scale (DIEPSS) score. Results: Between November 2015 and October 2016, 149 patients from 5 centers in Japan were enrolled. The median age was 67 years (range: 21–88 years) and the study population included 81 men (54.4%). The cancer types included lung (55 patients, 36.9%), upper gastrointestinal tract (5, 3.3%), hepatobiliary (19, 12.8%); breast (12, 8.1%); head and neck (10, 6.7%), gynecologic (10, 6.7%), genitourinary (10, 6.7%), and others (28, 18.8%). The median Karnofsky performance status was 60 (20–100). Most patients (86.6%) did not experience delirium. Thirty-nine (26.2%) patients received one or more EPS-inducing medications. EPSs occurred in 4 (2.7%) patients with a cutoff score of 5 points for 5 parkinsonism items in DIEPSS. Conclusion: A lower frequency (<3%) of patients than expected in this population had EPSs. Therefore, we concluded that an interventional study is not feasible. However, medications that cause EPSs are often used in palliative care; therefore, a longitudinal study is warranted. Trial registration: This study was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) (UMIN000019810) on 16, November, 2015.

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Section: Discussionmentioning

confidence: 99%

“…Rashid et al reported a 4.7% incidence of akathisia among patients taking antiemetic agents in a retrospective study in a tertiary cancer center. 20…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Extrapyramidal Symptoms in Cancer Patients Referred to Palliative Care: A Multicenter Observational Study (JORTC PAL12)

Ishiki

Hamano

Nagaoka

et al. 2020

Am J Hosp Palliat Care

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“…Several factors are associated with the occurrence of psychological distress in patients with cancer. The National Comprehensive Cancer Network guideline on distress management (2017) has summarized the risk factors of psychological distress as: a) health-related risk factors, b) personal risk factors, c) spiritual, d) social factors, and e) other risk factors - sexual and physical abuse, substance use disorders, and other mental disorders 23 . Via a critical appraisal of the literature, it is evident that the categorization of the associated factors for psychological distress differs in each study based on a given psycho-social context.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated factors of psychological distress among patients with oral cancer in Sri Lanka

Ratnasekera,

Perera,

Kandapola Arachchige

et al. 2024

Preprint

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Introduction Oral cancer is the most common among Sri Lankan males leading to psychological distress due to its impact on the appearance and vital functions. While the negative effects of psychological distress on these patients are well known, its prevalence and associated factors remain largely unknown in Sri Lanka. This study aimed to assess the prevalence and the associated factors of psychological distress among a selected patient cohort with oral cancer in Sri Lanka. Methods A hospital-based cross-sectional study was conducted among 355 patients with oral cancer to assess the prevalence of psychological distress. A nested case-control study among 140 (per arm) patients evaluated the associated factors for psychological distress. The multivariate analysis was carried out to identify significant factors associated with psychological distress. Results The prevalence of psychological distress among patients with oral cancer was 31.0% (95% CI = 27.8%- 35.3%). Being <50 years of age (Adjusted Odds Ratio (AOR)= 1.2, 95% CI= 0.7- 1.7, p= 0.006), having pain (AOR (Adjusted Odds Ratio)= 44.7, 95% CI= 34-53.21, p=0.001 ), late stages of cancer at the diagnosis (AOR= 10.7, 95% CI= 1.07- 28.78, p=0.04), being worried about basic functional disabilities (AOR= 11.4, 95% CI= 10.3- 14.8, p=0.006) and the two psychological factors emerged as significant independent factors that were associated with increased risk of psychological distress among patients with oral cancer. Conclusion One-third of patients with oral cancer in the selected tertiary care hospitals suffered from psychological distress indicating its high prevalence. Our findings on associated factors of psychological distress in patients with oral cancer have contributed to the development of an intervention strategy to reduce psychological distress in this population.

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“…Akathisia occurs in 4.7% of patients receiving older-generation antiemetics (metoclopramide and prochlorperazine); however, these are rarely used as frontline agents in current practice. 6 Trials that explored olanzapine as an appetite stimulant for cancer-related anorexia have used doses ranging from 2.5 mg once daily to a maximum of 5 mg once daily for 8-12 weeks but have not reported extrapyramidal symptoms. 7,8 However, in the phase I trial by Naing et al 9 (doses ranging from 2.5 mg to 20 mg once daily), one of 39 patients developed EPS at a dose of 20 mg once daily.…”

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confidence: 99%

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Reply to H. Onishi et al

Sandhya

Ganesan

2023

JCO

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Incidence of antiemetic‐induced akathisia in patients at a comprehensive cancer center

Abstract: Akathisia is an unpleasant feeling of motor restlessness with anxiety. Clinicians need to have a full understanding to identify the subtle difference between functional anxiety and akathisia.

Cited by 6 publications

References 8 publications

Prevalence of Extrapyramidal Symptoms in Cancer Patients Referred to Palliative Care: A Multicenter Observational Study (JORTC PAL12)

Prevalence of Extrapyramidal Symptoms in Cancer Patients Referred to Palliative Care: A Multicenter Observational Study (JORTC PAL12)

Prevalence and associated factors of psychological distress among patients with oral cancer in Sri Lanka

Reply to H. Onishi et al

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