Incidence of Aplastic Anemia in Viral Hepatitis in Children

Pikis, Andreas; Kavaliotis, John; Manios, S

doi:10.3109/00365548809117226

Cited by 19 publications

(14 citation statements)

References 6 publications

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“…The high frequency of aplastic anemia we and Tzakis et al an earlier epidemiological study in which the incidence of aplastic anemia among children with acute viral hepatitis was 0.07% (14). The cause for the large discrepancy in these sets of data is unknown.…”

Section: Discussionmentioning

confidence: 80%

“…Our results indicate that children who undergo liver transplantation for fulminant non-A, non-B hepatitis are at high risk of severe aplastic anemia perioperatively and concur with those reported in an earlier study by Tzakis et al (2). Aplastic anemia was associated with an earlier epidemiological study in which the incidence of aplastic anemia among children with acute viral hepatitis was 0.07% (14). The cause for the large discrepancy in these sets of data is unknown.…”

Section: Discussionmentioning

confidence: 95%

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Aplastic Anemia After Liver Transplantation for Fulminant Liver Failure

et al. 1994

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We determined the incidence and outcome of aplastic anemia among 56 patients who underwent liver transplantation for fulminant liver failure at the University of Nebraska Medical Center between July 1985 and December 1993. Aplastic anemia developed in 6 of 18 (33%) children and 1 of 19 (5%) adults who had fulminant non-A, non-B hepatitis; no cases of aplastic anemia occurred among patients with other causes of fulminant liver failure. None of these patients had evidence of a preexisting hematological disorder or infection with hepatitis C virus (as determined with a second-generation ELISA). Aplastic anemia was diagnosed at a median of 4 wk after the onset of hepatitis, with five cases seen before transplantation. Six patients received antithymocyte globulin to promote remission of aplastic anemia. Three children died (fungal infection in two, intracranial hemorrhage in one)--one at 43, one at 108 and one at 119 days after transplantation--without remission of aplastic anemia. Among the four surviving patients, with median follow-up of 25 mo, complete and partial remission of aplastic anemia have occurred in three and one, respectively. Liver allograft function is stable in all surviving patients. The data demonstrate that aplastic anemia is a common complication among children who undergo liver transplantation for fulminant non-A, non-B hepatitis. It is associated with a high rate of mortality, although most survivors appear to have full hematological recovery.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 95%

Aplastic Anemia After Liver Transplantation for Fulminant Liver Failure

et al. 1994

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“…5,6 Hepatites associated aplastic anemia was also found in few of the studies by autoantibody production and by T cell dysregulations. 3,[10][11][12] In this study total 7 cases were positive for hepatitis B and C, but all of them had history of blood transfusions, so these findings were ignored. 84% of aplastic anemia cases in this study were from the community belonging to rural areas.…”

Section: Discussionmentioning

confidence: 85%

Etiopathogenesis of aplastic anemia in children: a case control study

et al. 2017

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“…Although the incidence of AA in patients with acute viral hepatitis is estimated at 0.07%, AA has been observed in nearly one-third of the patients undergoing liver transplantation (LT) for FHF secondary to non-A-E hepatitis (1)(2)(3)(4). Most of this data have been derived from the pediatric population.…”

Section: Introductionmentioning

confidence: 99%